Search Results - "Cobham, M."

Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse by Jain, S., Cohen, J., Ward, M.M., Kornhauser, N., Chuang, E., Cigler, T., Moore, A., Donovan, D., Lam, C., Cobham, M.V., Schneider, S., Hurtado Rúa, S.M., Benkert, S., Mathijsen Greenwood, C., Zelkowitz, R., Warren, J.D., Lane, M.E., Mittal, V., Rafii, S., Vahdat, L.T.

“…Bone marrow-derived endothelial progenitor cells (EPCs) are critical for metastatic progression. This study explores the effect of tetrathiomolybdate (TM), an…”
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Phase I trial of ixabepilone plus pegylated liposomal doxorubicin in patients with adenocarcinoma of breast or ovary by Chuang, E., Wiener, N., Christos, P., Kessler, R., Cobham, M., Donovan, D., Goldberg, G.L., Caputo, T., Doyle, A., Vahdat, L., Sparano, J.A.

“…Background: Ixabepilone is a semisynthetic epothilone B analogue that is active in taxane-resistant cell lines and has shown activity in patients with…”
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Sexual transmission of human T-lymphotropic virus type I (HTLV-I) by Murphy, E L, Figueroa, J P, Gibbs, W N, Brathwaite, A, Holding-Cobham, M, Waters, D, Cranston, B, Hanchard, B, Blattner, W A

“…To study the seroprevalence of human T-lymphotropic virus type I (HTLV-I) in a sexually active population and to determine sexual behavior risk factors for…”
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Human T-lymphotropic virus type I (HTLV-I) seroprevalence in Jamaica. I. Demographic determinants by Murphy, E L, Figueroa, J P, Gibbs, W N, Holding-Cobham, M, Cranston, B, Malley, K, Bodner, A J, Alexander, S S, Blattner, W A

“…During 1985 and 1986, the authors measured antibodies to human T-lymphotropic virus type I (HTLV-I) in a cohort of 13,260 Jamaicans from all parts of the…”
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Abstract P1-10-10: Tumor infiltrating lymphocytes (TILS) among high risk for recurrence breast cancer patients treated with tetrathimolybdate (TM) by Rybstein, MD, Nackos, E, Kornhauser, N, Cigler, T, Andreopoulou, E, Moore, A, Cobham, M, Fitzpatrick, V, Demaria, S, Vahdat, LT

“…Background: Tumor infiltrating lymphocytes (TILs) evaluated in the primary tumor biopsy or surgical resection have been well established as having prognostic…”
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Abstract PD9-07: A phase II study of copper-depletion using tetrathiomolybdate (TM) in patients (pts) with high risk breast cancer (BC): Role of collagen processing and tumor microenvironment by Liu, YL, Bager, CL, Willumsen, N, Kornhauser, N, Cobham, M, Andreopoulou, E, Cigler, T, Moore, A, LaPolla, D, Fitzpatrick, V, Ward, M, Warren, JD, Mittal, V, Vahdat, LT

“…Background: Copper is an important catalytic cofactor in several biological functions and is essential for lysyl oxidase (LOX), a key enzyme in cross-linking…”
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Abstract P1-10-02: A phase II study of copper-depletion using tetrathiomolybdate in patients with breast cancer at high risk for recurrence: Updated results by Sahota, S, Willis, A, Kornhauser, N, Ward, M, Cobham, M, Cigler, T, Moore, A, Andreopoulou, E, Fitzpatrick, V, Schneider, S, Prima, N, Wiener, A, Ko, D, De Laurentiis, A, Warren, JD, Rubinchik, A, Mittal, V, Vahdat, LT

“…Background: Metals have emerged as a viable therapeutic target for a new generation of anti-cancer and anti-metastatic agents. Copper, an essential trace…”
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Abstract P3-02-02: Targeting the tumor microenvironment: A phase II study of copper-depletion using tetrathiomolybdate (TM) in patients (pts) with breast cancer (BC) at high risk for recurrence by Nackos, E, Willis, A, Kornhauser, N, Ward, M, Andreopoulou, E, Cigler, T, Moore, A, Fitzpatrick, V, Cobham, M, Schneider, S, Wiener, A, Guillaume-Abraham, J, Warren, JD, Rubinchik, A, Lane, M, Mittal, V, Vahdat, L

“…Background: Bone marrow derived VEGFR2+ endothelial progenitor cells (EPCs) and copper-dependent pathways, including lysyl oxidase (LOX), are critical…”
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Human T-lymphotropic virus type I (HTLV-I) seroprevalence in Jamaica. II. Geographic and ecologic determinants by Maloney, E M, Murphy, E L, Figueroa, J P, Gibbs, W N, Cranston, B, Hanchard, B, Holding-Cobham, M, Malley, K, Blattner, W A

“…An island-wide cohort of 13,260 Jamaicans who applied for food-handling licenses during 1985 and 1986 were tested for antibodies to human T-cell lymphotropic…”
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Abstract P2-16-14: The Effect of Tetrathiomolybdate (TM) on Circulating Endothelial Progenitor Cells in Women at Moderate to High Risk of BC Recurrence by Jain, S, Ward, MM, O'Laughlin, J, Chuang, E, Cigler, T, Moore, A, Donovan, D, Schneider, S, Cobham, M, Wiener, N, Lam, C, Christos, PJ, Lane, ME, Rafii, S, Vahdat, LT

“…Background: Bone marrow (BM) derived endothelial progenitor cells (EPCs) are critical to tumor angiogenesis, are increased in BC patients (pts) and are…”
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A Phase II Trial Tetrathiomolybdate (TM), a Copper Depleting Compound, and Its Effect on Circulating Endothelial Progenitor Cells (EPCs) in Patients with Breast Cancer (BC) at High Risk of Recurrence by Vahdat, L., Ward, M., Chuang, E., Cigler, T., Moore, A., Donovan, D., Cobham, M., Schpero, J., Wiener, N., Blinder, V., Christos, P., Rafii, S., Lane, M.

“…Background: EPCs are critical to tumor angiogenesis, are increased in BC patients (pts) and are probably an early marker for paclitaxel response. Copper is…”
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The effect of tetrathiomolybdate on endothelial progenitor cells in patients at high risk for breast cancer recurrence by Jain, S., Cohen, J. A., Ward, M. M., O'Loughlin, J., Boeck, M., Wiener, N., Chuang, E., Cigler, T., Moore, A., Donovan, D., Lam, C., Cobham, M. E., Schneider, S. E., Christos, P. J., Lane, M. E., Baergen, R., Mittal, V., Rafii, S., Vahdat, L. T.

“…Abstract only…”
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Phase I trial of a histone deacetylase inhibitor (HDACI) and retinoid acid (RA) in patients (pts) with advanced solid tumor malignancies by Atieh, D. M., Milowsky, M. I., Cobham, M., Kaplan, J., Smith, C., Gudas, L. J., Nanus, D. M.

“…Abstract only 13114 Background: Transcription of RA responsive genes is inhibited by co-repressor complexes which have HDAC activity. Pre-clinical data…”
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Future leadership in public health in the Commonwealth Caribbean, including the role of the University of the West Indies by Standard, K L, Holding-Cobham, M C

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Phase I/II trial of interferon α2b and ATRA-IV in the treatment of patients with advanced renal cancer by Nanus, D. M., Boorjian, S., Milowsky, M. I., Coll, D. M., Cobham, M., Kaplan, J., Shelton, G. E., Melia, J., Petrylak, D. P., Gudas, L. J.

“…Abstract only…”
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Phase 1/2 Clinical Trial of Interferon [alpha]2b and Weekly Liposome-encapsulated All-trans Retinoic Acid in Patients With Advanced Renal Cell Carcinoma by Boorjian, SA, Milowsky, MI, Kaplan, J, Albert, M, Cobham, M V, Coll, D M, Mongan, N P, Shelton, G, Petrylak, D, Gudas, L J, Nanus, D M

“…To evaluate the feasibility, efficacy, and biologic effects of weekly liposome-encapsulated all-trans retinoic acid (ATRA-IV) plus interferon [alpha]2b (IFN)…”
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Abstract P6-05-06: Association of HER2/neu single nucleotide polymorphism with trastuzumab-related cardiotoxicity by Chuang, E, Stanton, S, Ward, MM, Christos, P, Sanford, R, Lam, C, Cobham, MV, Donovan, D, Scheff, R, Cigler, T, Moore, A, Vahdat, LT, Lane, ME

“…Background: Treatment with trastuzumab prolongs overall survival when given to patients (pts) with Her2/neu+ breast cancer (BC). The primary toxicity of…”
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Abstract P6-11-04: Targeting the tumor microenvironment: tetrathiomolybdate decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse by Jain, S, Kornhauser, N, Lam, C, Ward, MM, Chuang, E, Cigler, T, Moore, A, Donovan, D, Cobham, MV, Schneider, S, Hurtado, Rua SM, Lane, ME, Mittal, V, Vahdat, LT

“…Background: Bone marrow-derived endothelial progenitor cells (EPCs) constitute an important part of the tumor microenvironment and are critical for metastatic…”
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Abstract P1-15-07: Ixabepilone-associated peripheral neuropathy in metastatic breast cancer patients and its effects on the ultrastructure of neurons by Jain, S, Carlson, K, Chuang, E, Cigler, T, Moore, A, Donovan, D, Lam, C, Cobham, MV, Schneider, S, Ramnarain, A, Carey, B, Ward, M, Lane, M, Strickland, S, Vahdat, L

“…Background: Peripheral neuropathy is a dose-limiting toxicity of most microtubule-stabilizing chemotherapeutic agents. Ixabepilone, a semisynthetic analog of…”
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The effect of tetrathiomolybdate on circulating endothelial progenitor cells in patients with breast cancer at high risk of recurrence by Blinder, VS, Lane, ME, Ward, MM, Chuang, E, Cigler, T, Moore, AL, Scheff, RJ, Cobham, ME, Donovan, D, Rice, D, Christos, PJ, Vahdat, LT

“…Abstract #1036 Background: Endothelial progenitor cells are critical to tumor angiogenesis and are increased in breast cancer patients. Copper is required for…”
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