Fine Needle Aspiration of the Vocal Fold Lamina Propria in an Animal Model

Fine Needle Aspiration of the Vocal Fold Lamina Propria in an Animal Model

Objectives: The development of a minimally invasive fine needle aspiration (FNA) technique for vocal fold (VF) biopsy would have far-reaching implications and applicability in laryngology. The objective of this study was to determine whether FNA of the VF lamina propria is feasible and whether it ca...

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Bibliographic Details
Published in:Annals of otology, rhinology & laryngology Vol. 115; no. 10; pp. 764 - 768
Main Authors: Cobell, Will, Duflo, Suzy M., Magrufov, Akhmar, Thibeault, Susan L.
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 01-10-2006
Annals Publishing Compagny
SAGE PUBLICATIONS, INC
Subjects:
Animals
Biological and medical sciences
Biopsy, Fine-Needle - adverse effects
Collagen - metabolism
Elastin - metabolism
Feasibility Studies
Medical sciences
Models, Animal
Mucous Membrane - metabolism
Mucous Membrane - pathology
Otorhinolaryngology. Stomatology
Rabbits
Vocal Cords - cytology
Vocal Cords - metabolism
Vocal Cords - pathology
collagen
vocal fold
biomechanical properties
scar
elastin
fine needle aspiration
Animal model
Scar
Elastin
Lamina propria
ENT
Vocal cord
Aspiration punction
Properties
Biomechanics
Collagen
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Summary:Objectives: The development of a minimally invasive fine needle aspiration (FNA) technique for vocal fold (VF) biopsy would have far-reaching implications and applicability in laryngology. The objective of this study was to determine whether FNA of the VF lamina propria is feasible and whether it causes injury to the VF. Methods: Unilateral VF FNA was performed with a 26-gauge needle on 20 rabbits. The FNA cell collection of the lamina propria was confirmed by cytology. Four weeks after the FNA, the rabbits were painlessly sacrificed and the larynges were harvested. Histologic analysis of the VF lamina propria included Masson's trichrome and elastin-van Gieson stains. The linear viscoelastic shear properties, elastic modulus, and viscous modulus of the tissue were measured. Results: Compared to the contralateral normal VFs, those VFs that underwent FNA demonstrated no significant differences in levels of collagen (p = .17) and elastin (p = .94). Rheologically, the elastic shear modulus and viscous modulus did not significantly differ between the normal and FNA VFs (p = .9380 and p = .9359, respectively). Conclusions: Fine needle aspiration of the VF lamina propria is feasible without injury and offers a potentially promising, less invasive alternative to be developed for future diagnostic and therapeutic management of VF lesions.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0003-4894
1943-572X
DOI:10.1177/000348940611501009