Search Results - "Cobelens, Pieter M"

Dexamethasone attenuates VEGF expression and inflammation but not barrier dysfunction in a murine model of ventilator-induced lung injury by Hegeman, Maria A, Hennus, Marije P, Cobelens, Pieter M, Kavelaars, Annemieke, Jansen, Nicolaas J G, Schultz, Marcus J, van Vught, Adrianus J, Heijnen, Cobi J

“…Ventilator-induced lung injury (VILI) is characterized by vascular leakage and inflammatory responses eventually leading to pulmonary dysfunction. Vascular…”
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Ventilator-induced endothelial activation and inflammation in the lung and distal organs by Hegeman, Maria A, Hennus, Marije P, Heijnen, Cobi J, Specht, Patricia Ac, Lachmann, Burkhard, Jansen, Nicolaas Jg, van Vught, Adrianus J, Cobelens, Pieter M

“…Results from clinical studies have provided evidence for the importance of leukocyte-endothelial interactions in the pathogenesis of pulmonary diseases such as…”
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Angiopoietin-1 treatment reduces inflammation but does not prevent ventilator-induced lung injury by Hegeman, Maria A, Hennus, Marije P, van Meurs, Matijs, Cobelens, Pieter M, Kavelaars, Annemieke, Jansen, Nicolaas J, Schultz, Marcus J, van Vught, Adrianus J, Molema, Grietje, Heijnen, Cobi J

“…Loss of integrity of the epithelial and endothelial barriers is thought to be a prominent feature of ventilator-induced lung injury (VILI). Based on its…”
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Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4 by Anne Vroon, Cobi J. Heijnen, Maria Stella Lombardi, Pieter M. Cobelens, Federico Mayor, Jr, Marc G. Caron, Annemieke Kavelaars

“…Chemokine receptors belong to the family of G‐protein‐coupled receptors (GPCR). Phosphorylation of GPCR by GPCR kinases (GRKs) is considered to play an…”
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Exogenous surfactant attenuation of ischemia–reperfusion injury in the lung through alteration of inflammatory and apoptotic factors by van Putte, Bart P., PhD, MD, Cobelens, Pieter M., PhD, van der Kaaij, Niels, PhD, Lachmann, Burkhard, PhD, MD, Kavelaars, Annemieke, PhD, Heijnen, Cobi J., PhD, Kesecioglu, Jozef, PhD, MD

“…Objective Lung ischemia–reperfusion injury is associated with impaired gas exchange from increased edema formation and surfactant inactivation. Surfactant…”
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Adjuvant Arthritis Induces Down-Regulation of G Protein-Coupled Receptor Kinases in the Immune System by Lombardi, Maria Stella, Kavelaars, Annemieke, Cobelens, Pieter M, Schmidt, Reinhold E, Schedlowski, Manfred, Heijnen, Cobi J

“…G protein-coupled receptors (GPCR) play a crucial role in the regulation of the immune response by, e.g., chemokines, PGs, and beta(2)-adrenergic agonists. The…”
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Stress-related peripheral neuroendocrine–immune interactions in women with ulcerative colitis by Langhorst, Jost, Cobelens, Pieter M, Kavelaars, Annemieke, Heijnen, Cobi J, Benson, Sven, Rifaie, Nadja, Dobos, Gustav J, Schedlowski, Manfred, Elsenbruch, Sigrid

“…Summary Objectives The mechanisms underlying the interaction of psychological stress with the disease course in inflammatory bowel diseases remain unclear. We…”
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Effect of Interferon-β on Neuroinflammation, Brain Injury and Neurological Outcome After Experimental Subarachnoid Hemorrhage by Tiebosch, Ivo A. C. W., Dijkhuizen, Rick M., Cobelens, Pieter M., Bouts, Mark J. R. J., Zwartbol, René, van der Meide, Peter H., van den Bergh, Walter M.

“…Introduction Aneurysmal subarachnoid hemorrhage (SAH) has a poor outcome, particularly attributed to progressive injury after the initial incident. Several…”
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Changes in innate and acquired immune responses in mice with targeted deletion of the dopamine transporter gene by Kavelaars, Annemieke, Cobelens, Pieter M., Teunis, Marc A.T., Heijnen, Cobi J.

“…The dopamine transporter (DAT) is responsible for the re-uptake of dopamine into presynaptic nerve terminals and thereby controls dopaminergic…”
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Neonatal Dexamethasone Treatment Increases Susceptibility to Experimental Autoimmune Disease in Adult Rats by Bakker, Joost M, Kavelaars, Annemieke, Kamphuis, Patrick J. G. H, Cobelens, Pieter M, van Vugt, Harmke H, van Bel, Frank, Heijnen, Cobi J

“…Major concern has emerged about the possible long term adverse effects of glucocorticoid treatment, which is frequently used for the prevention of chronic lung…”
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Tissue specific effects of the β 2-adrenergic agonist salbutamol on LPS-induced IFN-γ, IL-10 and TGF-β responses in vivo by Eijkelkamp, Niels, Cobelens, Pieter M., Sanders, Virginia M., Heijnen, Cobi J., Kavelaars, Annemieke

“…β 2-Adrenergic agonists have immunomodulatory effects both in vitro and in vivo. We describe that oral salbutamol (β-adrenergic agonist) administration has…”
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Treatment of adjuvant‐induced arthritis by oral administration of mycobacterial Hsp65 during disease by Cobelens, Pieter M., Heijnen, Cobi J., Nieuwenhuis, Edward E. S., Kramer, Peter P. G., Van Der Zee, Ruurd, Van Eden, Willem, Kavelaars, Annemieke

“…Objective Oral administration of antigen prior to disease induction has been shown to induce peripheral tolerance in several experimental autoimmune diseases…”
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Effect of Interferon-? on Neuroinflammation, Brain Injury and Neurological Outcome After Experimental Subarachnoid Hemorrhage by Tiebosch, Ivo ACW, Dijkhuizen, Rick M, Cobelens, Pieter M, Bouts, Mark JRJ, Zwartbol, Rene, Meide, Peter Hvan der, Bergh, Walter Mvan den

“…Aneurysmal subarachnoid hemorrhage (SAH) has a poor outcome, particularly attributed to progressive injury after the initial incident. Several studies suggest…”
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Interferon-b attenuates lung inflammation following experimental subarachnoid hemorrhage by Cobelens, Pieter M, Tiebosch, Ivo ACW, Dijkhuizen, Rick M, van der Meide, Peter H, Zwartbol, Rene, Heijnen, Cobi J, Kesecioglu, Jozef, van den Bergh, Walter M

“…Aneurysmal subarachnoid hemorrhage (SAH) affects relatively young people and carries a poor prognosis with a case fatality rate of 35%. One of the major…”
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Interferon-[beta] attenuates lung inflammation following experimental subarachnoid hemorrhage by Cobelens, Pieter M, Tiebosch, Ivo ACW, Dijkhuizen, Rick M, van der Meide, Peter H, Zwartbol, René, Heijnen, Cobi J, Kesecioglu, Jozef, van den Bergh, Walter M

“…Introduction Aneurysmal subarachnoid hemorrhage (SAH) affects relatively young people and carries a poor prognosis with a case fatality rate of 35%. One of the…”
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The β2-Adrenergic Agonist Salbutamol Potentiates Oral Induction of Tolerance, Suppressing Adjuvant Arthritis and Antigen-Specific Immunity by Cobelens, Pieter M., Kavelaars, Annemieke, Vroon, Anne, Ringeling, Marion, van der Zee, Ruurd, van Eden, Willem, Heijnen, Cobi J.

“…Abstract Therapeutic protocols for treating autoimmune diseases by feeding autoantigens during the disease process have not been very successful to date. In…”
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Tissue specific effects of the β2-adrenergic agonist salbutamol on LPS-induced IFN-γ, IL-10 and TGF-β responses in vivo by Eijkelkamp, Niels, Cobelens, Pieter M., Sanders, Virginia M., Heijnen, Cobi J., Kavelaars, Annemieke

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Oral antibiotics as a novel therapy for arthritis: Evidence for a beneficial effect of intestinal Escherichia coli by Nieuwenhuis, Edward E. S., Visser, Maarten R., Kavelaars, Annemieke, Cobelens, Pieter M., Fleer, Andre, Harmsen, Wil, Verhoef, Jan, Akkermans, Louis M. A., Heijnen, Cobi J.

“…Objective The intestinal flora is thought to play an important role in regulation of immune responses. We investigated the effects of changing the intestinal…”
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Oral antibiotics as a novel therapy for arthritis: Evidence for a beneficial effect of intestinalEscherichia coli by Nieuwenhuis, Edward E. S., Visser, Maarten R., Kavelaars, Annemieke, Cobelens, Pieter M., Fleer, Andre, Harmsen, Wil, Verhoef, Jan, Akkermans, Louis M. A., Heijnen, Cobi J.

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The beta 2-adrenergic agonist salbutamol potentiates oral induction of tolerance, suppressing adjuvant arthritis and antigen-specific immunity by Cobelens, Pieter M, Kavelaars, Annemieke, Vroon, Anne, Ringeling, Marion, van der Zee, Ruurd, van Eden, Willem, Heijnen, Cobi J

“…Therapeutic protocols for treating autoimmune diseases by feeding autoantigens during the disease process have not been very successful to date. In vitro it…”
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