Search Results - "Cobb, Brian A."

The history of IgG glycosylation and where we are now by Cobb, Brian A

“…Abstract IgG glycosylation is currently at the forefront of both immunology and glycobiology, likely due in part to the widespread and growing use of…”
Get full text

Glycobiology of immune responses by Rabinovich, Gabriel A., van Kooyk, Yvette, Cobb, Brian A.

“…Unlike their protein “roommates” and their nucleic acid “cousins," carbohydrates remain an enigmatic arm of biology. The central reason for the difficulty in…”
Get full text

Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy by Zhou, Julie Y, Alvarez, Carlos A, Cobb, Brian A

“…Cells exist within complex milieus of communicating factors, such as cytokines, that combine to generate context-specific responses, yet nearly all knowledge…”
Get full text

Characterization of Polysaccharide A Response Reveals Interferon Responsive Gene Signature and Immunomodulatory Marker Expression by Alvarez, Carlos A, Jones, Mark B, Hambor, John, Cobb, Brian A

“…Polysaccharide A (PSA), a capsular carbohydrate from the commensal gut bacteria , has been shown to possess both potent T cell-dependent pro- and…”
Get full text

Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars by Hiyoshi, Hirotaka, Wangdi, Tamding, Lock, Gabriel, Saechao, Cheng, Raffatellu, Manuela, Cobb, Brian A., Bäumler, Andreas J.

“…Typhoid fever caused by Salmonella enterica serovar (S.) Typhi differs in its clinical presentation from gastroenteritis caused by S. Typhimurium and other…”
Get full text

The Vi Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN by Zhang, Lillian F, Lepenies, Bernd, Nakamae, Sayuri, Young, Briana M, Santos, Renato L, Raffatellu, Manuela, Cobb, Brian A, Hiyoshi, Hirotaka, Bäumler, Andreas J

“…Capsular polysaccharides are common virulence factors of extracellular, but not intracellular bacterial pathogens, due to the antiphagocytic properties of…”
Get full text

CD45Rb-low effector T cells require IL-4 to induce IL-10 in FoxP3 Tregs and to protect mice from inflammation by Jones, Mark B, Alvarez, Carlos A, Johnson, Jenny L, Zhou, Julie Y, Morris, Nathan, Cobb, Brian A

“…CD4+ effector/memory T cells (Tem) represent a leading edge of the adaptive immune system responsible for protecting the body from infection, cancer, and other…”
Get full text

Roles for major histocompatibility complex glycosylation in immune function by Ryan, Sean O., Cobb, Brian A.

“…The major histocompatibility complex (MHC) glycoprotein family, also referred to as human leukocyte antigens, present endogenous and exogenous antigens to T…”
Get full text

Acute and chronic lung inflammation drives changes in epithelial glycans by Alvarez, Carlos A, Qian, Emily, Glendenning, Leandre M, Reynero, Kalob M, Kukan, Emily N, Cobb, Brian A

“…Asthma is the most common chronic inflammatory disease and it is characterized by leukocyte infiltration and tissue remodeling, with the latter generally…”
Get full text

A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2 by Wang, Qun, McLoughlin, Rachel M, Cobb, Brian A, Charrel-Dennis, Marie, Zaleski, Kathleen J, Golenbock, Douglas, Tzianabos, Arthur O, Kasper, Dennis L

“…Commensalism is critical to a healthy Th1/Th2 cell balance. Polysaccharide A (PSA), which is produced by the intestinal commensal Bacteroides fragilis,…”
Get full text

Mycobacterium tuberculosis Synergizes with ATP To Induce Release of Microvesicles and Exosomes Containing Major Histocompatibility Complex Class II Molecules Capable of Antigen Presentation by Ramachandra, Lakshmi, Qu, Yan, Wang, Ying, Lewis, Colleen J, Cobb, Brian A, Takatsu, Kiyoshi, Boom, W. Henry, Dubyak, George R, Harding, Clifford V

“…Major histocompatibility complex class II (MHC-II) molecules are released by murine macrophages upon lipopolysaccharide (LPS) stimulation and ATP signaling…”
Get full text

Polysaccharide Processing and Presentation by the MHCII Pathway by Cobb, Brian A, Wang, Qun, Tzianabos, Arthur O, Kasper, Dennis L

“…The adaptive immune system functions through the combined action of antigen-presenting cells (APCs) and T cells. Specifically, class I major histocompatibility…”
Get full text

Glycoform-selective prion formation in sporadic and familial forms of prion disease by Xiao, Xiangzhu, Yuan, Jue, Haïk, Stéphane, Cali, Ignazio, Zhan, Yian, Moudjou, Mohammed, Li, Baiya, Laplanche, Jean-Louis, Laude, Hubert, Langeveld, Jan, Gambetti, Pierluigi, Kitamoto, Tetsuyuki, Kong, Qingzhong, Brandel, Jean-Philippe, Cobb, Brian A, Petersen, Robert B, Zou, Wen-Quan

“…The four glycoforms of the cellular prion protein (PrP(C)) variably glycosylated at the two N-linked glycosylation sites are converted into their pathological…”
Get full text

Reply to Werner and Nimmerjahn letter to the Glyco-Forum by Cobb, Brian A

Get full text

Coming of age: carbohydrates and immunity by Cobb, Brian A., Kasper, Dennis L.

“…Adaptive immune responses have long been considered the “territory” of antigenic proteins, whereas carbohydrates are characterized as T‐cell‐independent…”
Get full text

IκB Kinase α Phosphorylation of TRAF4 Downregulates Innate Immune Signaling by Marinis, Jill M., Hutti, Jessica E., Homer, Craig R., Cobb, Brian A., Cantley, Lewis C., McDonald, Christine, Abbott, Derek W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

T cell-intrinsic TLR2 stimulation promotes IL-10 expression and suppressive activity by CD45RbHi T cells by Jun, Janice C, Jones, Mark B, Oswald, Douglas M, Sim, Edward S, Jonnalagadda, Amruth R, Kreisman, Lori S C, Cobb, Brian A

“…While Toll-like receptors (TLRs) represent one of the best characterized innate immune pathways, evidence suggests that TLRs are not restricted to innate…”
Get full text

Glycans in Immunologic Health and Disease by Zhou, Julie Y, Cobb, Brian A

“…The surfaces of all living organisms and most secreted proteins share a common feature: They are glycosylated. As the outermost-facing molecules, glycans…”
Get full text

The direct and indirect effects of glycans on immune function by Baum, Linda G, Cobb, Brian A

“…The biological impact of glycans is as diverse and complex as the impact of proteins on biology. Familiar roles include those as a protein folding checkpoint…”
Get full text

Activation of neutrophils by autocrine IL-17A–IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2 by Taylor, Patricia R, Roy, Sanhita, Leal, Sixto M, Sun, Yan, Howell, Scott J, Cobb, Brian A, Li, Xiaoxia, Pearlman, Eric

“…IL-17 production by neutrophils has been reported in human psoriasis. Pearlman and colleagues identify a population of neutrophils that constitutively express…”
Get full text