Search Results - "Cobb, Brian"

The history of IgG glycosylation and where we are now by Cobb, Brian A

“…Abstract IgG glycosylation is currently at the forefront of both immunology and glycobiology, likely due in part to the widespread and growing use of…”
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Reply to Werner and Nimmerjahn letter to the Glyco-Forum by Cobb, Brian A

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Glycobiology of immune responses by Rabinovich, Gabriel A., van Kooyk, Yvette, Cobb, Brian A.

“…Unlike their protein “roommates” and their nucleic acid “cousins," carbohydrates remain an enigmatic arm of biology. The central reason for the difficulty in…”
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Glycans in Immunologic Health and Disease by Zhou, Julie Y, Cobb, Brian A

“…The surfaces of all living organisms and most secreted proteins share a common feature: They are glycosylated. As the outermost-facing molecules, glycans…”
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The direct and indirect effects of glycans on immune function by Baum, Linda G, Cobb, Brian A

“…The biological impact of glycans is as diverse and complex as the impact of proteins on biology. Familiar roles include those as a protein folding checkpoint…”
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Activation of neutrophils by autocrine IL-17A–IL-17RC interactions during fungal infection is regulated by IL-6, IL-23, RORγt and dectin-2 by Taylor, Patricia R, Roy, Sanhita, Leal, Sixto M, Sun, Yan, Howell, Scott J, Cobb, Brian A, Li, Xiaoxia, Pearlman, Eric

“…IL-17 production by neutrophils has been reported in human psoriasis. Pearlman and colleagues identify a population of neutrophils that constitutively express…”
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B-cell–independent sialylation of IgG by Jones, Mark B., Oswald, Douglas M., Joshi, Smita, Whiteheart, Sidney W., Orlando, Ron, Cobb, Brian A.

“…IgG carrying terminal α2,6-linked sialic acids added to conserved N-glycans within the Fc domain by the sialyltransferase ST6Gal1 accounts for the…”
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Polysaccharide-experienced effector T cells induce IL-10 in FoxP3+ regulatory T cells to prevent pulmonary inflammation by Johnson, Jenny L, Jones, Mark B, Cobb, Brian A

“…Abstract Inhibition of peripheral inflammatory disease by carbohydrate antigens derived from normal gut microbiota has been demonstrated for the GI tract,…”
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Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy by Zhou, Julie Y, Alvarez, Carlos A, Cobb, Brian A

“…Cells exist within complex milieus of communicating factors, such as cytokines, that combine to generate context-specific responses, yet nearly all knowledge…”
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Glycosylation as a tracer of off-target Cre-lox activation in development by Glendenning, Leandre M, Reynero, Kalob M, Cobb, Brian A

“…The Cre-lox system is one of the most widely used methods for lineage-specific and inducible genome editing in vivo. However, incomplete penetrance and…”
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Siglecs as modulators of macrophage phenotype and function by Kukan, Emily N., Fabiano, Gabrielle L., Cobb, Brian A.

“…The sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of receptors expressed widely on cells of the hematopoietic system. Siglecs…”
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CD45Rb-low effector T cells require IL-4 to induce IL-10 in FoxP3 Tregs and to protect mice from inflammation by Jones, Mark B, Alvarez, Carlos A, Johnson, Jenny L, Zhou, Julie Y, Morris, Nathan, Cobb, Brian A

“…CD4+ effector/memory T cells (Tem) represent a leading edge of the adaptive immune system responsible for protecting the body from infection, cancer, and other…”
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The Glycoscience of Immunity by Zhou, Julie Y., Oswald, Douglas M., Oliva, Kelsey D., Kreisman, Lori S.C., Cobb, Brian A.

“…Carbohydrates, or glycans, are as integral to biology as nucleic acids and proteins. In immunology, glycans are well known to drive diverse functions ranging…”
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Polysaccharide A from the Capsule of Bacteroides fragilis Induces Clonal CD4+ T Cell Expansion by Johnson, Jenny L., Jones, Mark B., Cobb, Brian A.

“…For 3 decades, the view of MHCII-dependent antigen presentation has been completely dominated by peptide antigens despite our 2004 discovery in which MHCII was…”
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Divergent Golgi trafficking limits B cell‐mediated IgG sialylation by Glendenning, Leandre M., Zhou, Julie Y., Reynero, Kalob M., Cobb, Brian A.

“…The degree of α2,6‐linked sialylation on IgG glycans is associated with a variety of inflammatory conditions and is thought to drive IgG anti‐inflammatory…”
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Modulation of hepatocyte sialylation drives spontaneous fatty liver disease and inflammation by Oswald, Douglas M, Jones, Mark B, Cobb, Brian A

“…Abstract Circulatory protein glycosylation is a biomarker of multiple disease and inflammatory states and has been applied in the clinic for liver dysfunction,…”
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The regulatory power of glycans and their binding partners in immunity by Johnson, Jenny L, Jones, Mark B, Ryan, Sean O, Cobb, Brian A

“…Glycans and glycan-binding proteins are central to a properly functioning immune system. Perhaps the best known example of this is the selectin family of…”
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Characterization of Polysaccharide A Response Reveals Interferon Responsive Gene Signature and Immunomodulatory Marker Expression by Alvarez, Carlos A, Jones, Mark B, Hambor, John, Cobb, Brian A

“…Polysaccharide A (PSA), a capsular carbohydrate from the commensal gut bacteria , has been shown to possess both potent T cell-dependent pro- and…”
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ST6Gal1 in plasma is dispensable for IgG sialylation by Oswald, Douglas M, Lehoux, Sylvain D, Zhou, Julie Y, Glendenning, Leandre M, Cummings, Richard D, Cobb, Brian A

“…Abstract The glycosylation of immunoglobulin G (IgG) has attracted increased attention due to the impact of N-glycan modifications at N297 on IgG function,…”
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Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars by Hiyoshi, Hirotaka, Wangdi, Tamding, Lock, Gabriel, Saechao, Cheng, Raffatellu, Manuela, Cobb, Brian A., Bäumler, Andreas J.

“…Typhoid fever caused by Salmonella enterica serovar (S.) Typhi differs in its clinical presentation from gastroenteritis caused by S. Typhimurium and other…”
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