Search Results - "Cobaleda, César"

Childhood leukemia prevention within reach by Cobaleda, César, Sánchez-García, Isidro

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Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors by Busslinger, Meinrad, Jochum, Wolfram, Cobaleda, César

“…Lineage commitment and differentiation to a mature cell type are considered to be unidirectional and irreversible processes under physiological conditions. The…”
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Pax5: the guardian of B cell identity and function by Busslinger, Meinrad, Delogu, Alessio, Schebesta, Alexandra, Cobaleda, César

“…The transcription factor Pax5 is essential for commitment of lymphoid progenitors to the B lymphocyte lineage. Pax5 fulfils a dual role by repressing B lineage…”
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Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development by Busslinger, Meinrad, Delogu, Alessio, Strasser, Andreas, Bouillet, Philippe, Malin, Stephen, Cobaleda, César, Novatchkova, Maria, McManus, Shane

“…B cell development requires interleukin 7 signals that activate the transcription factor STAT5. Busslinger and colleagues report that STAT5 has a permissive…”
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Non-animal-derived monoclonal antibodies are not ready to substitute current hybridoma technology by González-Fernández, África, Bermúdez Silva, Francisco J., López-Hoyos, Marcos, Cobaleda, César, Montoliu, Lluís, Del Val, Margarita, Leech, Kirk

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Epigenetic Priming in Cancer Initiation by Vicente-Dueñas, Carolina, Hauer, Julia, Cobaleda, César, Borkhardt, Arndt, Sánchez-García, Isidro

“…Recent evidence from hematopoietic and epithelial tumors revealed that the contribution of oncogenes to cancer development is mediated mainly through…”
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Tumoral reprogramming: Plasticity takes a walk on the wild side by Campos-Sánchez, Elena, Cobaleda, César

“…Cellular plasticity is the capacity that cells have to change their fate and adopt a new identity. Plasticity is essential for normal development and for…”
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Instructive Role of the Transcription Factor E2A in Early B Lymphopoiesis and Germinal Center B Cell Development by Kwon, Kyongrim, Hutter, Caroline, Sun, Qiong, Bilic, Ivan, Cobaleda, César, Malin, Stephen, Busslinger, Meinrad

“…The transcription factor E2A controls the initiation of B lymphopoiesis, which is arrested at the pre-pro-B cell stage in E2A-deficient mice. Here, we…”
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Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis by Isidro-Hernández, Marta, Mayado, Andrea, Casado-García, Ana, Martínez-Cano, Jorge, Palmi, Chiara, Fazio, Grazia, Orfao, Alberto, Ribera, Jordi, Ribera, Josep Maria, Zamora, Lurdes, Raboso-Gallego, Javier, Blanco, Oscar, Alonso-López, Diego, De Las Rivas, Javier, Jiménez, Rafael, García Criado, Francisco Javier, García Cenador, María Begoña, Ramírez-Orellana, Manuel, Cazzaniga, Giovanni, Cobaleda, César, Vicente-Dueñas, Carolina, Sánchez-García, Isidro

“…PAX5 is one of the most frequently mutated genes in B-cell acute lymphoblastic leukemia (B-ALL), and children with inherited preleukemic PAX5 mutations are at…”
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Childhood B-Cell Preleukemia Mouse Modeling by Isidro-Hernández, Marta, Alemán-Arteaga, Silvia, Casado-García, Ana, Ruiz-Corzo, Belén, Riesco, Susana, Prieto-Matos, Pablo, Martínez-Cano, Jorge, Sánchez, Lucía, Cobaleda, César, Sánchez-García, Isidro, Vicente-Dueñas, Carolina

“…Leukemia is the most usual childhood cancer, and B-cell acute lymphoblastic leukemia (B-ALL) is its most common presentation. It has been proposed that…”
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Infection Exposure is a Causal Factor in B-cell Precursor Acute Lymphoblastic Leukemia as a Result of Pax5-Inherited Susceptibility by Martín-Lorenzo, Alberto, Hauer, Julia, Vicente-Dueñas, Carolina, Auer, Franziska, González-Herrero, Inés, García-Ramírez, Idoia, Ginzel, Sebastian, Thiele, Ralf, Constantinescu, Stefan N, Bartenhagen, Christoph, Dugas, Martin, Gombert, Michael, Schäfer, Daniel, Blanco, Oscar, Mayado, Andrea, Orfao, Alberto, Alonso-López, Diego, Rivas, Javier De Las, Cobaleda, César, García-Cenador, Maria Begoña, García-Criado, Francisco Javier, Sánchez-García, Isidro, Borkhardt, Arndt

“…Earlier in the past century, infections were regarded as the most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). However,…”
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B-cell acute lymphoblastic leukaemia: towards understanding its cellular origin by Cobaleda, César, Sánchez-García, Isidro

“…B-cell acute lymphoblastic leukaemia (B-ALL) is a clonal malignant disease originated in a single cell and characterized by the accumulation of blast cells…”
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Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice by Casado-García, Ana, Isidro-Hernández, Marta, Oak, Ninad, Mayado, Andrea, Mann-Ran, Christine, Raboso-Gallego, Javier, Alemán-Arteaga, Silvia, Buhles, Alexandra, Sterker, Dario, Sánchez, Elena G, Martínez-Cano, Jorge, Blanco, Oscar, Orfao, Alberto, Alonso-López, Diego, De Las Rivas, Javier, Riesco, Susana, Prieto-Matos, Pablo, González-Murillo, África, García Criado, Francisco Javier, García Cenador, María Begoña, Radimerski, Thomas, Ramírez-Orellana, Manuel, Cobaleda, César, Yang, Jun J, Vicente-Dueñas, Carolina, Weiss, Andreas, Nichols, Kim E, Sánchez-García, Isidro

“…Preventing development of childhood B-cell acute lymphoblastic leukemia (B-ALL), a disease with devastating effects, is a longstanding and unsolved challenge…”
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Developmental plasticity of lymphocytes by Cobaleda, César, Busslinger, Meinrad

“…Experimental perturbation of signaling or transcription factor networks has been used to study the developmental potential of lymphoid progenitors,…”
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Genetically engineered mouse models of human B-cell precursor leukemias by Hauer, Julia, Borkhardt, Arndt, Sánchez-García, Isidro, Cobaleda, César

“…B-cell precursor acute lymphoblastic leukemias (pB-ALLs) are the most frequent type of malignancies of the childhood, and also affect an important proportion…”
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Novel ETV6‐RUNX1 Mouse Model to Study the Role of ELF‐MF in Childhood B‐Acute Lymphoblastic Leukemia: a Pilot Study by Campos‐Sanchez, Elena, Vicente‐Dueñas, Carolina, Rodríguez‐Hernández, Guillermo, Capstick, Myles, Kuster, Niels, Dasenbrock, Clemens, Sánchez‐García, Isidro, Cobaleda, César

“…Exposure to extremely low‐frequency magnetic fields (ELF‐MFs) has been classified by the International Agency for Research on Cancer (IARC) as “possibly…”
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Cancer induction by restriction of oncogene expression to the stem cell compartment by Pérez-Caro, María, Cobaleda, César, González-Herrero, Inés, Vicente-Dueñas, Carolina, Bermejo-Rodríguez, Camino, Sánchez-Beato, Margarita, Orfao, Alberto, Pintado, Belén, Flores, Teresa, Sánchez-Martín, Manuel, Jiménez, Rafael, Piris, Miguel A, Sánchez-García, Isidro

“…In human cancers, all cancerous cells carry the oncogenic genetic lesions. However, to elucidate whether cancer is a stem cell‐driven tissue, we have developed…”
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theoretical basis of cancer-stem-cell-based therapeutics of cancer: can it be put into practice by Sánchez-García, Isidro, Vicente-Dueñas, Carolina, Cobaleda, César

“…In spite of the advances in our knowledge of cancer biology, most cancers remain not curable with present therapies. Current treatments consider cancer as…”
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NSD2 as a Promising Target in Hematological Disorders by Azagra, Alba, Cobaleda, César

“…Alterations of the epigenetic machinery are critically involved in cancer development and maintenance; therefore, the proteins in charge of the generation of…”
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Stem cell aging and cancer: Immortal but vulnerable by Cobaleda, César, Sanchez-García, Isidro

“…Comment on: Vicente-Dueñas C, et al. Aging 2010; 2:908-13…”
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