Search Results - "Coats, Bonnie"

Long-term safety of dichloroacetate in congenital lactic acidosis by Abdelmalak, Monica, Lew, Alicia, Ramezani, Ryan, Shroads, Albert L., Coats, Bonnie S., Langaee, Taimour, Shankar, Meena N., Neiberger, Richard E., Subramony, S.H., Stacpoole, Peter W.

“…We followed 8 patients (4 males) with biochemically and/or molecular genetically proven deficiencies of the E1α subunit of the pyruvate dehydrogenase complex…”
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Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women by Zhao, Mei, Lamers, Yvonne, Ralat, Maria A, Coats, Bonnie S, Chi, Yueh-Yun, Muller, Keith E, Bain, James R, Shankar, Meena N, Newgard, Christopher B, Stacpoole, Peter W, Gregory, 3rd, Jesse F

“…Previous animal studies showed that severe vitamin B-6 deficiency altered fatty acid profiles of tissue lipids, often with an increase of linoleic acid and a…”
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Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate by Shroads, Albert L., Langaee, Taimour, Coats, Bonnie S., Kurtz, Tracie L., Bullock, John R., Weithorn, David, Gong, Yan, Wagner, David A., Ostrov, David A., Johnson, Julie A., Stacpoole, Peter W.

“…Dichloroacetate (DCA), a chemical relevant to environmental science and allopathic medicine, is dehalogenated by the bifunctional enzyme glutathione…”
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Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor by Davis, Steven R, Stacpoole, Peter W, Williamson, Jerry, Kick, Lilia S, Quinlivan, Eoin P, Coats, Bonnie S, Shane, Barry, Bailey, Lynn B, Gregory, 3rd, Jesse F

“…Hyperhomocysteinemia in humans is associated with genetic variants of several enzymes of folate and one-carbon metabolism and deficiencies of folate and…”
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Chloral hydrate, through biotransformation to dichloroacetate, inhibits maleylacetoacetate isomerase and tyrosine catabolism in humans by Shroads, Albert L, Coats, Bonnie S, Langaee, Taimour, Shuster, Jonathan J, Stacpoole, Peter W

“…Chloral hydrate (CH), a sedative and metabolite of the environmental contaminant trichloroethylene, is metabolized to trichloroacetic acid, trichloroethanol,…”
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Dietary vitamin B-6 restriction does not alter rates of homocysteine remethylation or synthesis in healthy young women and men by Davis, S.R, Scheer, J.B, Quinlivan, E.P, Coats, B.S, Stacpoole, P.W, Gregory, J.F. III

“…Background: The effects of vitamin B-6 status on steady-state kinetics of homocysteine metabolism in humans are unclear. Objective: The objective was to…”
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The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women by Davis, Steven R, Quinlivan, Eoin P, Shelnutt, Karla P, Maneval, David R, Ghandour, Haifa, Capdevila, Antonieta, Coats, Bonnie S, Wagner, Conrad, Selhub, Jacob, Bailey, Lynn B, Shuster, Jonathan J, Stacpoole, Peter W, Gregory, 3rd, Jesse F

“…Whether folate status and the methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism interact to affect methionine-cycle metabolite concentrations…”
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Human polymorphisms in the glutathione transferase zeta 1 maleylacetoacetate isomerase gene predict the kinetics and toxicity of dichloroacetate by Shroads, A. Larry, Langaee, Taimour, Coats, Bonnie S., Kurtz, Tracie L., Bullock, John, Weithorn, David, Gong, Yan, Wagner, David, Ostrov, David A., Johnson, Julie A., Stacpoole⁎, Peter W.

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Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women by Davis, Steven R, Quinlivan, Eoin P, Shelnutt, Karla P, Ghandour, Haifa, Capdevila, Antonieta, Coats, Bonnie S, Wagner, Conrad, Shane, Barry, Selhub, Jacob, Bailey, Lynn B, Shuster, Jonathan J, Stacpoole, Peter W, Gregory, 3rd, Jesse F

“…The effects of folate status and the methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism on the kinetics of homocysteine metabolism are unclear…”
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Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women by da Silva, Vanessa R, Rios-Avila, Luisa, Lamers, Yvonne, Ralat, Maria A, Midttun, Øivind, Quinlivan, Eoin P, Garrett, Timothy J, Coats, Bonnie, Shankar, Meena N, Percival, Susan S, Chi, Yueh-Yun, Muller, Keith E, Ueland, Per Magne, Stacpoole, Peter W, Gregory, 3rd, Jesse F

“…Suboptimal vitamin B-6 status, as reflected by low plasma pyridoxal 5'-phosphate (PLP) concentration, is associated with increased risk of vascular disease…”
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Association of one‐carbon and tryptophan metabolites with vitamin B‐6 concentrations in oral contraceptive users (827.7) by Rios‐Avila, Luisa, Coats, Bonnie, Chi, Yueh‐Yun, Midttun, Øivind, Ueland, Per, Stacpoole, Peter, Gregory, Jesse

“…Vitamin B‐6 in the form of pyridoxal 5’‐phosphate (PLP) serves as a coenzyme in 1C metabolism and tryptophan (trp) catabolism. In 1C metabolism, PLP acts a…”
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Metabolite profile analysis reveals association of vitamin B-6 with metabolites related to one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in oral contraceptive users and reveals the effects of oral contraceptives on these processes by Rios-Avila, Luisa, Coats, Bonnie, Chi, Yueh-Yun, Midttun, Øivind, Ueland, Per M, Stacpoole, Peter W, Gregory, 3rd, Jesse F

“…The use of oral contraceptives (OCs) has been associated with low plasma pyridoxal 5'-phosphate (PLP). The functional consequences are unclear. To determine…”
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Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6–insufficient oral contraceptive users12 by Rios-Avila, Luisa, Coats, Bonnie, Ralat, Maria, Chi, YuehYun, Midttun, Øivind, Ueland, Per M, Stacpoole, Peter W, Gregory, Jesse F

“…Background: Low chronic vitamin B-6 status can occur in a subset of women who use oral contraceptives (OCs) with uncertain metabolic consequences. An…”
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Effects of vitamin B6 on one‐carbon metabolism in oral contraceptive users by Rios‐Avila, Luisa, Ralat, Maria, Coats, Bonnie, Stacpoole, Peter W., Gregory, Jesse F.

“…Abstract only Oral contraceptive (OC) usage is associated with low plasma pyridoxal phosphate (PLP) indicating low vitamin B6 status. PLP serves as a coenzyme…”
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Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users by Rios-Avila, Luisa, Coats, Bonnie, Ralat, Maria, Chi, Yueh-Yun, Midttun, Øivind, Ueland, Per M, Stacpoole, Peter W, Gregory, 3rd, Jesse F

“…Low chronic vitamin B-6 status can occur in a subset of women who use oral contraceptives (OCs) with uncertain metabolic consequences. An insufficiency of…”
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Moderate vitamin B-6 restriction does not alter postprandial methionine cycle rates of remethylation, transmethylation, and total transsulfuration but increases the fractional synthesis rate of cystathionine in healthy young men and women by Lamers, Yvonne, Coats, Bonnie, Ralat, Maria, Quinlivan, Eoin P, Stacpoole, Peter W, Gregory, 3rd, Jesse F

“…Methionine is the precursor for S-adenosylmethionine (SAM), the major 1-carbon donor involved in >100 transmethylation reactions. Homocysteine produced from…”
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Vitamin B‐6 Restriction Alters Concentrations of One‐Carbon (1C) Metabolites in Healthy Human Subjects by Silva, Vanessa R., Quinlivan, Eoin, Lamers, Yvonne, Coats, Bonnie, Stacpoole, Peter W., Gregory, Jesse F.

“…Metabolic profiling of the effects of a marginal B‐6 deficiency can provide insight into the sensitivity of 1C metabolism to B‐6 status, and the level of…”
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Long-term safety of dichloroacetate in congenital lactic acidosis by Abdelmalak, Monica, Lew, Alicia, Ramezani, Ryan, Shroads, Albert L., Coats, Bonnie S., Shankar, Meena N., Stacpoole, Peter W.

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Marginal Vitamin B6 Deficiency Affects Fatty Acid Profiles in Healthy Men and Women by Zhao, Mei, Lamers, Yvonne, Ralat, Maria A, Coats, Bonnie S, Stacpoole, Peter W, Chi, Yueh‐Yun, Muller, Keith E, Bain, James R, Newgard, Christopher B, Gregory, Jesse F

“…Severe vitamin B6 (VB6) deficiency alters fatty acid (FA) profiles of rat tissue lipids. The aim of this study was to determine effects of marginal VB6…”
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Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate by Jia, Minghong, Coats, Bonnie, Chadha, Monisha, Frentzen, Barbara, Perez-Rodriguez, Javier, Chadik, Paul A, Yost, Richard A, Henderson, George N, Stacpoole, Peter W

“…Dichloroacetate (DCA) is a putative environmental hazard, owing to its ubiquitous presence in the biosphere and its association with animal and human toxicity…”
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