Search Results - "Coates, Jonathan A V"

Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design by Peat, Thomas S, Rhodes, David I, Vandegraaff, Nick, Le, Giang, Smith, Jessica A, Clark, Lisa J, Jones, Eric D, Coates, Jonathan A V, Thienthong, Neeranat, Newman, Janet, Dolezal, Olan, Mulder, Roger, Ryan, John H, Savage, G Paul, Francis, Craig L, Deadman, John J

“…A fragment-based screen against human immunodeficiency virus type 1 (HIV) integrase led to a number of compounds that bound to the lens epithelium derived…”
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Antiviral agents 3. Discovery of a novel small molecule non-nucleoside inhibitor of Hepatitis B Virus (HBV) by Crosby, Ian T., Bourke, David G., Jones, Eric D., Jeynes, Tyrone P., Cox, Susan, Coates, Jonathan A.V., Robertson, Alan D.

“…The discovery of a small molecule non-nucleoside inhibitor of Hepatitis B Virus is described. During our work on conocurvone derived naphthoquinone ‘trimers’…”
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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold by Jones, Eric D., Vandegraaff, Nick, Le, Giang, Choi, Neil, Issa, William, Macfarlane, Katherine, Thienthong, Neeranat, Winfield, Lisa J., Coates, Jonathan A.V., Lu, Long, Li, Xinming, Feng, Xiao, Yu, Changjiang, Rhodes, David I., Deadman, John J.

“…HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Nine variations of the core scaffold are evaluated leading to optimization…”
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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators by Le, Giang, Vandegraaff, Nick, Rhodes, David I., Jones, Eric D., Coates, Jonathan A.V., Thienthong, Neeranat, Winfield, Lisa J., Lu, Long, Li, Xinming, Yu, Changjiang, Feng, Xiao, Deadman, John J.

“…Synthesis of a diverse set of azoles and their utilizations as an amide isostere in the design of HIV integrase inhibitors is described. The Letter identified…”
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Antiviral agents 2. Synthesis of trimeric naphthoquinone analogues of conocurvone and their antiviral evaluation against HIV by Crosby, Ian T., Bourke, David G., Jones, Eric D., de Bruyn, Paula J., Rhodes, David, Vandegraaff, Nick, Cox, Susan, Coates, Jonathan A.V., Robertson, Alan D.

“…The synthesis of a new series of conocurvone analogues is presented that explores the importance of the pyran rings of conocurvone, their degree of…”
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Discovery of potent HIV integrase inhibitors active against raltegravir resistant viruses by Le, Giang, Vandegraaff, Nick, Rhodes, David I., Jones, Eric D., Coates, Jonathan A.V., Lu, Long, Li, Xinming, Yu, Changjiang, Feng, Xiao, Deadman, John J.

“…A series of novel HIV integrase inhibitors active against rategravir resistant strains are reported. Initial SAR studies revealed that activities against…”
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Correction: Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design by Peat, Thomas S., Rhodes, David I., Vandegraaff, Nick, Le, Giang, Smith, Jessica A., Clark, Lisa J., Jones, Eric D., Coates, Jonathan A. V., Thienthong, Neeranat, Newman, Janet, Dolezal, Olan, Mulder, Roger, Ryan, John H., Savage, G. Paul, Francis, Craig L., Deadman, John J.

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Crystal Structures of Novel Allosteric Peptide Inhibitors of HIV Integrase Identify New Interactions at the LEDGF Binding Site by Rhodes, David I., Peat, Thomas S., Vandegraaff, Nick, Jeevarajah, Dharshini, Newman, Janet, Martyn, John, Coates, Jonathan A. V., Ede, Nicholas J., Rea, Philip, Deadman, John J.

“…An optimised method of solution cyclisation gave us access to a series of peptides including SLKIDNLD (2). We investigated the crystallographic complexes of…”
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Structural Basis for a New Mechanism of Inhibition of H I V-1 Integrase Identified by Fragment Screening and Structure-Based Design by Rhodes, David I, Peat, Thomas S, Vandegraaff, Nick, Jeevarajah, Dharshini, Le, Giang, Jones, Eric D, Smith, Jessica A, Coates, Jonathan AV, Winfeld, Lisa J, Thienthong, Neeranat, Newman, Janet, Lucent, Del, Ryan, John H, Savage, G Paul, Francis, Craig L, Deadman, John J

“…Background: HIV-1 integrase is a clinically validated therapeutic target for the treatment of HIV-1 infection, with one approved therapeutic currently on the…”
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Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil by Borthwick, Alan D, Evans, Derek N, Kirk, Barrie E, Biggadike, Keith, Exall, Anne M, Youds, Peter, Roberts, Stanley M, Knight, David J, Coates, Jonathan A. V

“…The racemic carbocyclic 2'-fluoroarabinosyl pyrimidine nucleosides 8, 9 (C-FIAU), 12, and 13 (C-FMAU) and the 2'-fluororibosyl pyrimidine nucleosides 17, 20,…”
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Identification and Characterization of a Herpes Simplex Virus Gene Product Required for Encapsidation of Virus DNA by Preston, V G, Coates, J A, Rixon, F J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Penicillin derived C2-symmetric dimers as novel inhibitors of HIV-1 proteinase by Humber, David C, Cammack, Nicholas, Coates, Jonathan A. V, Cobley, Kevin N, Orr, David C, Storer, Richard, Weingarten, Gordon G, Weir, Malcolm P

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Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design by Rhodes, David I, Peat, Thomas S, Vandegraaff, Nick, Jeevarajah, Dharshini, Le, Giang, Jones, Eric D, Smith, Jessica A, Coates, Jonathan A V, Winfield, Lisa J, Thienthong, Neeranat, Newman, Janet, Lucent, Del, Ryan, John H, Savage, G Paul, Francis, Craig L, Deadman, John J

“…HIV-1 integrase is a clinically validated therapeutic target for the treatment of HIV-1 infection, with one approved therapeutic currently on the market. This…”
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Fluorocarbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic 2'-deoxyguanosines by Borthwick, Alan D, Kirk, Barrie E, Biggadike, Keith, Exall, Anne M, Butt, Suzanne, Roberts, Stanley M, Knight, David J, Coates, Jonathan A. V, Ryan, D. Michael

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Genetic and biochemical studies with temperature-sensitive mutants of herpes simplex virus type 1 by Coates, Jonathan A. V

“…The work presented in this thesis describes the isolation of a series of temperature-sensitive (1s) mutants of herpes simplex virus type 1 (HSV-1), Glasgow…”
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