Search Results - "Coarfa, C"

BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells by Sun, B, Fiskus, W, Qian, Y, Rajapakshe, K, Raina, K, Coleman, K G, Crew, A P, Shen, A, Saenz, D T, Mill, C P, Nowak, A J, Jain, N, Zhang, L, Wang, M, Khoury, J D, Coarfa, C, Crews, C M, Bhalla, K N

“…Bromodomain extraterminal protein (BETP) inhibitors transcriptionally repress oncoproteins and nuclear factor-κB (NF-κB) target genes that undermines the…”
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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells by Saenz, D T, Fiskus, W, Qian, Y, Manshouri, T, Rajapakshe, K, Raina, K, Coleman, K G, Crew, A P, Shen, A, Mill, C P, Sun, B, Qiu, P, Kadia, T M, Pemmaraju, N, DiNardo, C, Kim, M-S, Nowak, A J, Coarfa, C, Crews, C M, Verstovsek, S, Bhalla, K N

“…The PROTAC (proteolysis-targeting chimera) ARV-825 recruits bromodomain and extraterminal (BET) proteins to the E3 ubiquitin ligase cereblon, leading to…”
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SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein by Geng, C, Kaochar, S, Li, M, Rajapakshe, K, Fiskus, W, Dong, J, Foley, C, Dong, B, Zhang, L, Kwon, O-J, Shah, S S, Bolaki, M, Xin, L, Ittmann, M, O'Malley, B W, Coarfa, C, Mitsiades, N

“…The E3 ubiquitin ligase adaptor speckle-type POZ protein (SPOP) is frequently dysregulated in prostate adenocarcinoma (PC), via either somatic mutations or…”
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Comprehensive proteomic profiling identifies the androgen receptor axis and other signaling pathways as targets of microRNAs suppressed in metastatic prostate cancer by Coarfa, C, Fiskus, W, Eedunuri, V K, Rajapakshe, K, Foley, C, Chew, S A, Shah, S S, Geng, C, Shou, J, Mohamed, J S, O'Malley, B W, Mitsiades, N

“…MicroRNAs are important epigenetic regulators of protein expression by triggering degradation of target mRNAs and/or inhibiting their translation…”
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BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells by Saenz, D T, Fiskus, W, Manshouri, T, Rajapakshe, K, Krieger, S, Sun, B, Mill, C P, DiNardo, C, Pemmaraju, N, Kadia, T, Parmar, S, Sharma, S, Coarfa, C, Qiu, P, Verstovsek, S, Bhalla, K N

“…Myeloproliferative neoplasms with myelofibrosis (MPN-MF) demonstrate constitutive activation of Janus kinase/signal transducer and activator of transcription…”
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TAp63 suppresses mammary tumorigenesis through regulation of the Hippo pathway by Su, X, Napoli, M, Abbas, H A, Venkatanarayan, A, Bui, N H B, Coarfa, C, Gi, Y J, Kittrell, F, Gunaratne, P H, Medina, D, Rosen, J M, Behbod, F, Flores, E R

“…Mechanisms regulating the transition of mammary epithelial cells (MECs) to mammary stem cells (MaSCs) and to tumor-initiating cells (TICs) have not been…”
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S21-03 Implementing precision environmental health using multi-omics and machine learning by Coarfa, C.

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A multi-platform co-array Fortran compiler by Dotsenko, Y., Coarfa, C., Mellor-Crummey, J.

“…Co-array Fortran (CAF) - a small set of extensions to Fortran 90 - is an emerging model for scalable, global address space parallel programming. CAF's global…”
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267 Establishment of a new immunocompetent mouse model of merkel cell carcinoma by Prieto-Sarmiento, K.M., de Mingo Pulido, A., Sell, B.R., Chiang, O. Chavez, Harms, P.W., Verhaegen, M.E., Dlugosz, A., Patel, T., Coarfa, C., Tsai, K.

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(378) Donorexosomebiomarkers for Primary Graft Dysfunction in Transplants Using Ex-Vivo Lung Perfusion by Kanchi, R., Chacon, L., D'Silva, E., Salan-Gomez, M., Leon-Pena, A., Castillo, M., Gunaratne, P., Mendez, C. Hochman, Coarfa, C., Loor, G.

“…Portable normothermic ex-vivo lung perfusion (EVLP) is increasingly used during lung transplant, enabling donor pool expansion and improved donor lung…”
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Abstract P5-18-10: BHLHE40-AS1 is an enhancer associated long noncoding RNA critical to breast cancer progression by DeVaux, RS, Schimjawicz, H, Coarfa, C, Behbod, F, Herschkowitz, JI

“…Abstract Increased emphasis on breast cancer screening has led to a dramatic increase in diagnosis of ductal carcinoma in situ (DCIS). DCIS lesions are…”
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Abstract P5-07-11: BHLHE40-AS1 is an enhancer associated noncoding RNA critical to breast cancer progression by DeVaux, RKS, Schimjawicz, H, Coarfa, C, Behbod, F, Herschkowitz, JI

“…Abstract Increased emphasis on breast cancer screening has led to a dramatic increase in diagnosis of ductal carcinoma in situ (DCIS). DCIS lesions are…”
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Abstract P1-02-03: The Y537S ESR1 mutation carries unique metabolomics profiling in breast cancer by Gu, G, Piyarathna, B, Coarfa, C, Ellis, L, Ando', S, Fuqua, S

“…Abstract Background: Estrogen receptor (ESR1) mutations occur at a high frequency in metastatic breast tumors in patients treated with hormonal therapy in the…”
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Abstract PD7-11: Therapeutic strategy for ESR1 mutation driven-endocrine resistance in ER-positive breast cancers by Kim, J-A, Dustin, D, Gu, G, Corona-Rodriguez, A, Edwards, D, Coarfa, C, Keyomarsi, K, Fuqua, SA

“…Abstract Background: Endocrine therapy is used in estrogen receptor (ER)-positive breast cancers, however, 25% of these patients are at risk of distant relapse…”
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Random 3-SAT: The plot thickens by COARFA, Cristian, DEMOPOULOS, Demetrios D, SAN MIGUEL AGUIRRE, Alfonso, SUBRAMANIAN, Devika, VARDI, Moshe Y

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Single-Molecule Sequencing Reveals Estrogen-Regulated Clinically Relevant lncRNAs in Breast Cancer by Jonsson, Philip, Coarfa, Cristian, Mesmar, Fahmi, Raz, Tal, Rajapakshe, Kimal, Thompson, John F, Gunaratne, Preethi H, Williams, Cecilia

“…Estrogen receptor (ER)α-positive tumors are commonly treated with ERα antagonists or inhibitors of estrogen synthesis, but most tumors develop resistance, and…”
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PAPD5-mediated 3′ adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease by Boele, Joost, Persson, Helena, Shin, Jay W., Ishizu, Yuri, Newie, Inga S., Søkilde, Rolf, Hawkins, Shannon M., Coarfa, Cristian, Ikeda, Kazuhiro, Takayama, Ken-ichi, Horie-Inoue, Kuniko, Ando, Yoshinari, Burroughs, A. Maxwell, Sasaki, Chihiro, Suzuki, Chizuru, Sakai, Mizuho, Aoki, Shintaro, Ogawa, Ayumi, Hasegawa, Akira, Lizio, Marina, Kaida, Kaoru, Teusink, Bas, Carninci, Piero, Suzuki, Harukazu, Inoue, Satoshi, Gunaratne, Preethi H., Rovira, Carlos, Hayashizaki, Yoshihide, de Hoon, Michiel J. L.

“…Next-generation sequencing experiments have shown that microRNAs (miRNAs) are expressed in many different isoforms (isomiRs), whose biological relevance is…”
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Abstract P4-15-03: Regulation of miRNA-29c and its gene targets in preneoplastic progression of triple negative breast cancer by Bhardwaj, A, Tachibana, K, Ganesan, N, Rajapakshe, K, Singh, H, Gunaratne, P, Coarfa, C, Bedrosian, I

“…Abstract Introduction: Little is understood about the early molecular drivers of the triple negative breast cancer making identification of women at risk and…”
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098 A cohort of miRNAs can be used as an early predictive biomarker of UV-driven cutaneous squamous cell carcinoma by Nguyen, T., Rajapakshe, K., Chitsazzadeh, V., Nicholas, C., Coarfa, C., Tsai, K.

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D28 THE WEB OF OMICS: DNA, RNA, AND PROTEIN MODIFICATIONS: Sex-Specific Differences In The Transcriptome And Epigenome In Neonatal Hyperoxic Lung Injury: Implications For Bronchopulmonary Dysplasia by Lingappan, K, Zhang, Y, Maity, S, Jiang, W, Wang, L, Coarfa, C, Moorthy, B

“…In this study, we employed a non-biased approach to measure global changes in gene expression and DNA methylation following hyperoxia exposure in male and…”
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