Search Results - "Coan, Kristin E D"

Stoichiometry and Physical Chemistry of Promiscuous Aggregate-Based Inhibitors by Coan, Kristin E. D, Shoichet, Brian K

“…Many false positives in early drug discovery owe to nonspecific inhibition by colloid-like aggregates of organic molecules. Despite their prevalence, little is…”
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Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding by Coan, Kristin E. D, Maltby, David A, Burlingame, Alma L, Shoichet, Brian K

“…One of the leading sources of false positives in early drug discovery is the formation of organic small molecule aggregates, which inhibit enzymes…”
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Stability and equilibria of promiscuous aggregates in high protein milieus by Coan, Kristin E D, Shoichet, Brian K

“…At micromolar concentrations, many molecules form aggregates in aqueous solution. In this form, they inhibit enzymes non-specifically leading to false positive…”
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Measurement and Differentiation of Ligand-Induced Calmodulin Conformations by Dual Polarization Interferometry by Coan, Kristin E. D., Swann, Marcus J., Ottl, Johannes

“…In early drug discovery, knowledge about ligand-induced conformational changes and their influence on protein activity greatly aids the identification of lead…”
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