Search Results - "Coakley, Dion"

Fasting Blood Ammonia Predicts Risk and Frequency of Hepatic Encephalopathy Episodes in Patients With Cirrhosis by Vierling, John M, Mokhtarani, Masoud, Brown, Robert S, Mantry, Parvez, Rockey, Don C, Ghabril, Marwan, Rowell, Richard, Jurek, Marzena, Coakley, Dion F, Scharschmidt, Bruce F

“…Background & Aims There is controversy over the use of measuring blood levels of ammonia (NH3 ) in the management of patients with overt hepatic encephalopathy…”
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Efficacy and Safety of Tenofovir DF vs Stavudine in Combination Therapy in Antiretroviral-Naive Patients: A 3-Year Randomized Trial by Gallant, Joel E, Staszewski, Schlomo, Pozniak, Anton L, DeJesus, Edwin, Suleiman, Jamal M. A. H, Miller, Michael D, Coakley, Dion F, Lu, Biao, Toole, John J, Cheng, Andrew K, for the 903 Study Group

“…CONTEXT Tenofovir disoproxil fumarate (DF) is a once-daily nucleotide analogue reverse transcriptase inhibitor. OBJECTIVE To evaluate the efficacy and safety…”
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Ammonia control and neurocognitive outcome among urea cycle disorder patients treated with glycerol phenylbutyrate by Diaz, George A., Krivitzky, Lauren S., Mokhtarani, Masoud, Rhead, William, Bartley, James, Feigenbaum, Annette, Longo, Nicola, Berquist, William, Berry, Susan A., Gallagher, Renata, Lichter‐Konecki, Uta, Bartholomew, Dennis, Harding, Cary O., Cederbaum, Stephen, McCandless, Shawn E., Smith, Wendy, Vockley, Gerald, Bart, Stephen A., Korson, Mark S., Kronn, David, Zori, Roberto, Merritt, J. Lawrence, C.S. Nagamani, Sandesh, Mauney, Joseph, LeMons, Cynthia, Dickinson, Klara, Moors, Tristen L., Coakley, Dion F., Scharschmidt, Bruce F., Lee, Brendan

“…Glycerol phenylbutyrate is under development for treatment of urea cycle disorders (UCDs), rare inherited metabolic disorders manifested by hyperammonemia and…”
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Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate by Smith, Wendy, MD, Diaz, George A., MD, PhD, Lichter-Konecki, Uta, MD, PhD, Berry, Susan A., MD, Harding, Cary O., MD, McCandless, Shawn E., MD, LeMons, Cindy, Mauney, Joe, MS, Dickinson, Klara, BS, Coakley, Dion F., PharmD, Moors, Tristen, MS, Mokhtarani, Masoud, MD, Scharschmidt, Bruce F., MD, Lee, Brendan, MD, PhD

“…Objectives To examine ammonia levels, pharmacokinetics, and safety of glycerol phenylbutyrate (GPB; also referred to as HPN-100) and sodium phenylbutyrate…”
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Glycerol phenylbutyrate treatment in children with urea cycle disorders: Pooled analysis of short and long-term ammonia control and outcomes by Berry, Susan A., Lichter-Konecki, Uta, Diaz, George A., McCandless, Shawn E., Rhead, William, Smith, Wendy, LeMons, Cynthia, Nagamani, Sandesh C.S., Coakley, Dion F., Mokhtarani, Masoud, Scharschmidt, Bruce F., Lee, Brendan

“…To evaluate glycerol phenylbutyrate (GPB) in the treatment of pediatric patients with urea cycle disorders (UCDs). UCD patients (n=26) ages 2months through…”
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Blood ammonia and glutamine as predictors of hyperammonemic crises in patients with urea cycle disorder by Lee, Brendan, Diaz, George A., Rhead, William, Lichter-Konecki, Uta, Feigenbaum, Annette, Berry, Susan A., Le Mons, Cindy, Bartley, James A., Longo, Nicola, Nagamani, Sandesh C., Berquist, William, Gallagher, Renata, Bartholomew, Dennis, Harding, Cary O., Korson, Mark S., McCandless, Shawn E., Smith, Wendy, Cederbaum, Stephen, Wong, Derek, Merritt, J. Lawrence, Schulze, Andreas, Vockley, Gerard, Kronn, David, Zori, Roberto, Summar, Marshall, Milikien, Douglas A., Marino, Miguel, Coakley, Dion F., Mokhtarani, Masoud, Scharschmidt, Bruce F.

“…Purpose: The aim of this study was to examine predictors of ammonia exposure and hyperammonemic crises in patients with urea cycle disorders. Methods: The…”
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Phase I/II Trial of the Pharmacokinetics, Safety, and Antiretroviral Activity of Tenofovir Disoproxil Fumarate in Human Immunodeficiency Virus-Infected Adults by BARDITCH-CROVO, Patricia, DEEKS, Steven G, MCGOWAN, I. A. N, LIETMAN, Paul S, COLLIER, A. N. N, SAFRIN, Sharon, COAKLEY, Dion F, MILLER, Michael, KEARNEY, Brian P, COLEMAN, Rebecca L, LAMY, Patrick D, KAHN, James O

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Self-reported treatment-associated symptoms among patients with urea cycle disorders participating in glycerol phenylbutyrate clinical trials by Nagamani, Sandesh C S, Diaz, George A, Rhead, William, Berry, Susan A, Le Mons, Cynthia, Lichter-Konecki, Uta, Bartley, James, Feigenbaum, Annette, Schulze, Andreas, Longo, Nicola, Berquist, William, Gallagher, Renata, Bartholomew, Dennis, Harding, Cary O, Korson, Mark S, McCandless, Shawn E, Smith, Wendy, Vockley, Jerry, Kronn, David, Zori, Robert, Cederbaum, Stephen, Merritt, 2nd, J Lawrence, Wong, Derek, Coakley, Dion F, Scharschmidt, Bruce F, Dickinson, Klara, Marino, Miguel, Lee, Brendan H, Mokhtarani, Masoud

“…Health care outcomes have been increasingly assessed through health-related quality of life (HRQoL) measures. While the introduction of nitrogen-scavenging…”
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Tenofovir disoproxil fumarate in nucleoside-resistant HIV-1 infection: A randomized trial by SQUIRES, Kathleen, POZNIAK, Anton L, COAKLEY, Dion F, CHENG, Andrew, PIERONE, Gerald JR, STEINHART, Corklin R, BERGER, Daniel, BELLOS, Nicholaos C, BECKER, Stephen L, WULFSOHN, Michael, MILLER, Michael D, TOOLE, John J

“…Resistance to antiretroviral agents remains a leading cause of treatment failure for patients infected with HIV-1. To describe the efficacy and safety of…”
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Variation in Liver Biochemistries in Patients with Decompensated Cirrhosis: Implications for Assessing Drug-Induced Liver Injury in Clinical Trials by Jurek, Marzena, Mokhtarani, Masoud, Vierling, John M., Coakley, Dion F., Ganju, Jitendra, Rowell, Richard, Scharschmidt, Bruce F.

“…Background Current approaches to detection of drug-induced liver injury (DILI) are generally based on changes from normal in biochemical liver tests. However,…”
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Su1686 Fasting Ammonia (Nh3 ) As a Predictor of Hepatic Encephalopathy (HE) Events by Vierling, John M, Mokhtarani, Masoud, Brown, Robert S, Mantry, Parvez S, Rockey, Don C, Ghabril, Marwan, Coakley, Dion F, Milikien, Douglas A, Scharschmidt, Bruce

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Patterns of Resistance Emerging in HIV-1 From Antiretroviral-Experienced Patients Undergoing Intensification Therapy With Tenofovir Disoproxil Fumarate by McColl, Damian J, Margot, Nicolas A, Wulfsohn, Michael, Coakley, Dion F, Cheng, Andrew K, Miller, Michael D

“…Study GS-99-907 was a 48-week, phase 3, double-blind, placebo-controlled intensification trial of tenofovir disoproxil fumarate (tenofovir DF)…”
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Glycerol Phenylbutyrate in Patients With Cirrhosis and Episodic Hepatic Encephalopathy: A Pilot Study of Safety and Effect on Venous Ammonia Concentration by Ghabril, Marwan, Zupanets, Igor A., Vierling, John, Mantry, Parvez, Rockey, Don, Wolf, David, O'Shea, Robert, Dickinson, Klara, Gillaspy, Heather, Norris, Catherine, Coakley, Dion F., Mokhtarani, Masoud, Scharschmidt, Bruce F.

“…Glycerol tri‐(4‐phenylbutyrate) (glycerol phenylbutyrate, GPB, HPN‐100) mediates waste nitrogen excretion through conjugation with glutamine to form…”
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542 Glycerol Phenylbutyrate (GPB) Administration in Patients With Cirrhosis and Episodic Hepatic Encephalopathy (HE) by Ghabril, Marwan, Zupanets, Igor A, Vierling, John M, Mantry, Parvez S, Rockey, Don C, Wolf, David S, O'Shea, Robert, Dickinson, Klara, Gillaspy, Heather, Norris, Catherine, Coakley, Dion F, Mokhtarani, Masoud, Scharschmidt, Bruce

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Determining the antiviral activity of tenofovir disoproxil fumarate in treatment-naive chronically HIV-1-infected individuals by LOUIE, Michael, HOGAN, Christine, PERELSON, Alan S, MARKOWITZ, Martin, HURLEY, Arlene, SIMON, Viviana, CHUNG, Chris, PADTE, Neal, LAMY, Patrick, FLAHERTY, John, COAKLEY, Dion, DI MASCIO, Michele

“…To assess the efficacy of tenofovir disoproxil fumarate (TDF) monotherapy by following the initial rate of decline in plasma viral load, which is a measure of…”
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Single-Dose and Steady-State Pharmacokinetics of Tenofovir Disoproxil Fumarate in Human Immunodeficiency Virus-Infected Children by Hazra, Rohan, Balis, Frank M, Tullio, Antonella N, DeCarlo, Ellen, Worrell, Carol J, Steinberg, Seth M, Flaherty, John F, Yale, Kitty, Poblenz, Marianne, Kearney, Brian P, Zhong, Lijie, Coakley, Dion F, Blanche, Stephane, Bresson, Jean Louis, Zuckerman, Judith A, Zeichner, Steven L

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Effect of Tenofovir Disoproxil Fumarate on the Pharmacokinetics and Pharmacodynamics of Total, R-, and S-Methadone by Smith, Patrick F., Kearney, Brian P., Liaw, Sandra, Cloen, Denise, Bullock, Julie M., Haas, Curtis E., Yale, Kitty, Booker, Brent M., Berenson, Charles S., Coakley, Dion F., Flaherty, John F.

“…Study Objective. To evaluate the potential effect of tenofovir disoproxil fumarate (DF) on the pharmacokinetics of methadone. Design. Phase I, open‐label,…”
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Phase I/II study of the pharmacokinetics, safety and antiretroviral activity of tenofovir alafenamide, a new prodrug of the HIV reverse transcriptase inhibitor tenofovir, in HIV-infected adults by Markowitz, Martin, Zolopa, Andrew, Squires, Kathleen, Ruane, Peter, Coakley, Dion, Kearney, Brian, Zhong, Lijie, Wulfsohn, Michael, Miller, Michael D, Lee, William A

“…Tenofovir alafenamide (formerly GS-7340) is a new oral prodrug of tenofovir, a nucleotide analogue that inhibits HIV-1 reverse transcription. Unlike the…”
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Single-Dose Pharmacokinetics and Safety of the Oral Antiviral Compound Adefovir Dipivoxil in Children Infected with Human Immunodeficiency Virus Type 1 by HUGHES, W. T, SHENEP, J. L, ZIMMER, B, BURCHETT, S, READ, J. S, RODMAN, J. H, FRIDLAND, A, WILLOUGHBY, R, BLANCHARD, S, PURDUE, L, COAKLEY, D. F, CUNDY, K. C, CULNANE, M

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Randomized, double‐blind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy by Rockey, Don C., Vierling, John M., Mantry, Parvez, Ghabril, Marwan, Brown, Robert S., Alexeeva, Olga, Zupanets, Igor A., Grinevich, Vladimir, Baranovsky, Andrey, Dudar, Larysa, Fadieienko, Galyna, Kharchenko, Nataliya, Klaryts'ka, Iryna, Morozov, Vyacheslav, Grewal, Priya, McCashland, Timothy, Reddy, K. Gautham, Reddy, K. Rajender, Syplyviy, Vasyl, Bass, Nathan M., Dickinson, Klara, Norris, Catherine, Coakley, Dion, Mokhtarani, Masoud, Scharschmidt, Bruce F.

“…Glycerol phenylbutyrate (GPB) lowers ammonia by providing an alternate pathway to urea for waste nitrogen excretion in the form of phenylacetyl glutamine,…”
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