Search Results - "Coșkun, Süleyman"
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PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans
Published in Nature medicine (01-12-2021)“…Intracranial aneurysm (IA) rupture leads to subarachnoid hemorrhage, a sudden-onset disease that often causes death or severe disability. Although genome-wide…”
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Integrated genomic characterization of IDH1-mutant glioma malignant progression
Published in Nature genetics (01-01-2016)“…Murat Günel and colleagues use an integrated genomic approach to analyze the malignant progression of IDH1 -mutant gliomas. They observe nonlinear clonal…”
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Integrated genomic analyses of de novo pathways underlying atypical meningiomas
Published in Nature communications (14-02-2017)“…Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and…”
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Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells
Published in Cell reports (Cambridge) (23-10-2014)“…Hematopoietic stem cells (HSCs) reside within a specialized niche where interactions with vasculature, osteoblasts, and stromal components regulate their…”
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Acoustic evidence of shallow gas accumulations and active pockmarks in the İzmir Gulf, Aegean sea
Published in Marine and petroleum geology (01-08-2011)“…Based on high-resolution Chirp seismic, multibeam bathymetry and side scan sonar data collected in the İzmir Gulf, Aegean Sea in 2008 and 2010, gas-related…”
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Integrated genomic analyses of de novo pathways underlying atypical meningiomas
Published in Nature communications (20-04-2018)“…This corrects the article DOI: 10.1038/ncomms14433…”
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Correction: Author Correction: Integrated genomic analyses of de novo pathways underlying atypical meningiomas
Published in Nature communications (20-04-2018)“…Nature Communications 8: Article number: 14433 (2017) Published online 14 February 2017; Updated 20 April 2018 In this Article, a subset of the H3K27ac…”
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In utero nanoparticle delivery for site-specific genome editing
Published in Nature communications (26-06-2018)“…Genetic diseases can be diagnosed early during pregnancy, but many monogenic disorders continue to cause considerable neonatal and pediatric morbidity and…”
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Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture
Published in Biotechnology and bioengineering (01-04-2016)“…ABSTRACT Hematopoietic stem cells (HSCs) have been used therapeutically for decades, yet their widespread clinical use is hampered by the inability to expand…”
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Post-traumatic glioblastoma multiforme: a case report
Published in The Eurasian journal of medicine (01-04-2011)“…Malignant glioma development after trauma is a rare occurrence. We report a glioblastoma multiforme case that developed after a depressed skull fracture. A…”
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Optimum designs for 2-D and 3-D seismic surveys via modeling and reverse-time migration: Pierce Junction Salt Dome, Texas
Published in Surveys in geophysics (01-09-2021)“…Establishing effective seismic survey parameters in complex structural areas, such as salt domes, is of vital importance for accurate imaging. Shot and group…”
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Pulmonary Radiological Findings in Patients with Acute Myeloid Leukemia and Their Relationship to Chemotherapy and Prognosis: A Single-Center Retrospective Study
Published in Turkish journal of haematology (01-09-2012)“…Objective : Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Pulmonary are among the most common causes of mortality in AML. This…”
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Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control
Published in Developmental cell (09-12-2013)“…Delineating the mechanism or mechanisms that regulate the specification of hemogenic endothelial cells from primordial endothelium is critical for optimizing…”
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Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis
Published in Neuro-oncology (Charlottesville, Va.) (01-10-2015)“…Malignant high-grade gliomas (HGGs), including the most aggressive form, glioblastoma multiforme, show significant clinical and genomic heterogeneity. Despite…”
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Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity
Published in Cell stem cell (05-11-2010)“…Mdm2 is an E3 ubiquitin ligase that targets p53 for degradation. p53 515C (encoding p53R172P) is a hypomorphic allele of p53 that rescues the embryonic…”
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A patient with a novel homozygous missense mutation in FTO and concomitant nonsense mutation in CETP
Published in Journal of human genetics (01-05-2016)“…The fat mass and obesity associated (FTO) gene has previously been associated with a variety of diseases and conditions, notably obesity, acute coronary…”
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Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments
Published in Birth defects research. Part C. Embryo today (01-12-2010)“…Hematopoietic stem cells (HSC) are multi‐potent cells that function to generate a lifelong supply of all blood cell types. During mammalian embryogenesis,…”
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Sac Metal Şekillendirmede Kalıp Alıştırması Için Sonlu Elemanlar Yöntemi Ile Telafi Çalışması
Published 01-01-2023“…Otomobil modellerinde yapılan değişiklikler ve ürün geliştirme süreçlerinin kısaltmasının yanı sıra otomobil sac gövde bileşenlerinin kalitesine yönelik artan…”
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Dissertation -
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141 Meningioma With Multiple Drivers: Genomic Landscape and Clinical Correlations
Published in Neurosurgery (01-09-2018)“…Abstract INTRODUCTION The majority of meningioma cluster into mutually exclusive groups with distinctive clinical correlations based on a mutation in one of…”
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