Search Results - "Cnubben, Nicole H.P"

The interplay of glutathione-related processes in antioxidant defense by Cnubben, Nicole H.P, Rietjens, Ivonne M.C.M, Wortelboer, Heleen, van Zanden, Jelmer, van Bladeren, Peter J

“…This review summarizes current knowledge on glutathione (GSH) associated cellular processes that play a central role in defense against oxidative stress. GSH…”
Get full text

Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2 by van Zanden, Jelmer J., Wortelboer, Heleen M., Bijlsma, Sabina, Punt, Ans, Usta, Mustafa, Bladeren, Peter J. van, Rietjens, Ivonne M.C.M., Cnubben, Nicole H.P.

“…In the present study, the effects of a large series of flavonoids on multidrug resistance proteins (MRPs) were studied in MRP1 and MRP2 transfected MDCKII…”
Get full text

Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients by Brand, Walter, Schutte, Maaike E., Williamson, Gary, van Zanden, Jelmer J., Cnubben, Nicole H.P., Groten, John P., van Bladeren, Peter J., Rietjens, Ivonne M.C.M.

“…The transcellular transport of ingested food ingredients across the intestinal epithelial barrier is an important factor determining bioavailability upon oral…”
Get full text

The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids by Rietjens, Ivonne M.C.M., Boersma, Marelle G., Haan, Laura de, Spenkelink, Bert, Awad, Hanem M., Cnubben, Nicole H.P., van Zanden, Jelmer J., Woude, Hester van der, Alink, Gerrit M., Koeman, Jan H.

“…Natural antioxidants like vitamin C, vitamin E, carotenoids, and polyphenols like flavonoids, are at present generally considered to be beneficial components…”
Get full text

Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells by van Zanden, Jelmer J, Geraets, Liesbeth, Wortelboer, Heleen M, Bladeren, Peter J.van, Rietjens, Ivonne M.C.M, Cnubben, Nicole H.P

“…The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump…”
Get full text

Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin by van Zanden, Jelmer J., de Mul, Anika, Wortelboer, Heleen M., Usta, Mustafa, van Bladeren, Peter J., Rietjens, Ivonne M.C.M., Cnubben, Nicole H.P.

“…In the present study, the effects of myricetin on either MRP1 or MRP2 mediated vincristine resistance in transfected MDCKII cells were examined. The results…”
Get full text

Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1 by Evers, Raymond, Cnubben, Nicole H.P, Wijnholds, Jan, van Deemter, Liesbeth, van Bladeren, Peter J, Borst, Piet

“…The human multidrug resistance protein MRP1 mediates transport of organic substrates conjugated to glutathione, glucuronide, or sulfate. The naturally…”
Get full text

Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2 by Wortelboer, Heleen M, Balvers, Michiel G.J, Usta, Mustafa, van Bladeren, Peter J, Cnubben, Nicole H.P

“…Abstract The interactions of three heavy metal-containing compounds, cisplatin (CDDP), arsenic trioxide (As2 O3 ), and mercury dichloride (HgCl2 ), with the…”
Get full text

Comparative in Vitro– in Vivo Percutaneous Penetration of the Fungicide ortho-Phenylphenol by Cnubben, Nicole H.P., Elliott, Graham R., Hakkert, Betty C., Meuling, Wim J.A., van de Sandt, Johannes J.M.

“…The validity of in vitro and in vivo methods for the prediction of percutaneous penetration in humans was assessed using the fungicide ortho-phenylphenol (OPP)…”
Get full text

antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach by Bakker, Gertruud CM, van Erk, Marjan J, Pellis, Linette, Wopereis, Suzan, Rubingh, Carina M, Cnubben, Nicole HP, Kooistra, Teake, van Ommen, Ben, Hendriks, Henk FJ

“…BACKGROUND: Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. OBJECTIVE: It was hypothesized…”
Get full text

Disposition of glycolic acid into the embryo following oral administration of ethylene glycol during placentation in the rat and rabbit by Moore, Nigel P, Bogaards, Jan J P, Buscher, Brigitte A P, Wolterbeek, André P M, Cnubben, Nicole H P

“…Abstract In order to evaluate the role of the placenta in the etiology of ethylene glycol (EG) developmental toxicity, the distribution of EG and its main…”
Get full text

Use of the kinetically-derived maximum dose concept in selection of top doses for toxicity studies hampers proper hazard assessment and risk management by Heringa, Minne B., Cnubben, Nicole H.P., Slob, Wout, Pronk, Marja E.J., Muller, Andre, Woutersen, Marjolijn, Hakkert, Betty C.

“…The KMD (kinetically-derived maximum dose) is an increasingly advocated concept that uses toxicokinetic data in the top dose selection for toxicity testing…”
Get full text

Regulating human safety: How dose selection in toxicity studies impacts human health hazard assessment and subsequent risk management options by Woutersen, Marjolijn, Muller, Andre, Pronk, Marja E.J., Cnubben, Nicole H.P., Hakkert, Betty C.

“…In the EU, one of the key determinants in the regulation and management of substances to ensure adequate protection of human health is the outcome of toxicity…”
Get full text

Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system by VAN IERSEL, M. L. P. S, CNUBBEN, N. H. P, SMINK, N, KOEMAN, J. H, VAN BLADEREN, P. J

“…The cyclopentenone prostaglandin A2 (PGA2) is known to inhibit cell proliferation, and metabolism of this compound thus might be important in controlling its…”
Get full text

Towards harmonization of test methods for in vitro hepatic clearance studies by Louisse, Jochem, Alewijn, Martin, Peijnenburg, Ad A.C.M., Cnubben, Nicole H.P., Heringa, Minne B., Coecke, Sandra, Punt, Ans

“…Non-animal methods for toxicokinetics, such as in vitro hepatic metabolic clearance studies, play an important role in chemical risk evaluations. To gain…”
Get full text

Rebuttal to the letter to the editors regarding Heringa et al. (2020) by Heringa, Minne B., Cnubben, Nicole H.P., Slob, Wout, Pronk, Marja E.J., Muller, Andre, Woutersen, Marjolijn, Hakkert, Betty C.

Get full text

Rebuttal to the letters to the editors by Terry et al. and Sewell et al. regarding by Heringa, Minne B., Cnubben, Nicole H.P., Slob, Wout, Pronk, Marja E.J., Muller, Andre, Woutersen, Marjolijn, Hakkert, Betty C.

Get full text

The urinary metabolic profile of diethylene glycol methyl ether and triethylene glycol methyl ether in Sprague-Dawley rats and the role of the metabolite methoxyacetic acid in their toxicity by Kelsey, Jeffrey R., Cnubben, Nicole H.P., Bogaards, Jan J.P., Braakman, René B.H., van Stee, Leo L.P., Smet, Karen

“…Ethylene glycol ethers are a well-known series of solvents and hydraulic fluids derived from the reaction of ethylene oxide and monoalcohols. Use of methanol…”
Get full text

Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis by Kleemann, Robert, Verschuren, Lars, van Erk, Marjan J, Nikolsky, Yuri, Cnubben, Nicole H P, Verheij, Elwin R, Smilde, Age K, Hendriks, Henk F J, Zadelaar, Susanne, Smith, Graham J, Kaznacheev, Valery, Nikolskaya, Tatiana, Melnikov, Anton, Hurt-Camejo, Eva, van der Greef, Jan, van Ommen, Ben, Kooistra, Teake

“…Increased dietary cholesterol intake is associated with atherosclerosis. Atherosclerosis development requires a lipid and an inflammatory component. It is…”
Get full text

Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status by Pellis, Linette, van Erk, Marjan J., van Ommen, Ben, Bakker, Gertruud C. M., Hendriks, Henk F. J., Cnubben, Nicole H. P., Kleemann, Robert, van Someren, Eugene P., Bobeldijk, Ivana, Rubingh, Carina M., Wopereis, Suzan

“…We introduce the metabolomics and proteomics based Postprandial Challenge Test (PCT) to quantify the postprandial response of multiple metabolic processes in…”
Get full text