Dedifferentiated acinic cell carcinoma of the parotid gland: A distinct rarely described entity

A case of dedifferentiated acinic cell carcinoma of the parotid gland is presented. A 46-year-old man presented with a parotid gland mass. At surgery the tumor was found adherent to the temporal bone and cervical adenopathy was present. Treatment included radical parotidectomy and intraoperative rad...

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Bibliographic Details
Published in:	Human pathology Vol. 28; no. 7; pp. 869 - 873
Main Authors:	Henley, John D, Geary, William A, Jackson, Cynthia L, Wu, C.Daniel, Cnepp, Douglas R
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-07-1997 Elsevier
Subjects:	acinic cell carcinoma Biological and medical sciences Carcinoma, Acinar Cell - genetics Carcinoma, Acinar Cell - metabolism Carcinoma, Acinar Cell - pathology dedifferentiated dedifferentiation DNA, Neoplasm Genes, p53 Humans Immunohistochemistry Male Medical sciences Middle Aged Otorhinolaryngology. Stomatology p53 parotid gland Parotid Neoplasms - genetics Parotid Neoplasms - metabolism Parotid Neoplasms - pathology Polymerase Chain Reaction Polymorphism, Single-Stranded Conformational salivary gland Tumor Suppressor Protein p53 - metabolism Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology salivary gland ACC dedifferentiated DACC PAS PCR-SSCP dedifferentiation acinic cell carcinoma parotid gland p53 Human Immunohistochemistry Parotid gland Male Malignant tumor Case study Polymerase chain reaction Pathology Acinar cell carcinoma Salivary gland disease TP53 Gene C-Onc gene ENT disease Adult Molecular biology Protooncogene Tumor suppressor gene
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Summary:	A case of dedifferentiated acinic cell carcinoma of the parotid gland is presented. A 46-year-old man presented with a parotid gland mass. At surgery the tumor was found adherent to the temporal bone and cervical adenopathy was present. Treatment included radical parotidectomy and intraoperative radiotherapy. Histologically, the tumor was a composite of a usual low-grade acinic cell carcinoma and high-grade, poorly differentiated carcinoma. Cervical lymph node metastases were composed entirely of high-grade carcinoma. Immunohistochemically, both low- and high-grade malignant components were negative for p53 oncoprotein expression. Moreover, polymerase chain reaction and nonisotopic single-stranded conformational polymorphism analyses were consistent with a germ line configuration of the p53 gene, exons five through eight, in both low- and high-grade elements of the tumor. The literature on this unusual variant of acinic cell carcinoma is reviewed.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0046-8177 1532-8392
DOI:	10.1016/S0046-8177(97)90164-7