Search Results - "Cmelik, Richard"

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    Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity by Rouchal, Michal, Rudolfová, Jana, Kryštof, Vladimír, Vojáčková, Veronika, Čmelík, Richard, Vícha, Robert

    “…Cyclin-dependent kinases (CDKs) play an important role in the cell-division cycle. Synthetic inhibitors of CDKs are based on 2,6,9-trisubstituted purines and…”
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    Journal Article
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    Enzybiotics LYSSTAPH-S and LYSDERM-S as Potential Therapeutic Agents for Chronic MRSA Wound Infections by Vacek, Lukáš, Kobzová, Šárka, Čmelík, Richard, Pantůček, Roman, Janda, Lubomír

    Published in Antibiotics (Basel) (01-08-2020)
    “…Antibacterial antibiotic therapy has played an important role in the treatment of bacterial infections for almost a century. The increasing resistance of…”
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    Journal Article
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    Fluorescein-based low-molecular-mass markers of isoelectric point for tracing pH gradient using high sensitivity capillary isoelectric focusing with laser-induced fluorescence detection by Dadajová, Pavlína, Čmelík, Richard, Šlais, Karel, Duša, Filip

    Published in Analytica chimica acta (01-12-2024)
    “…Successful implementation of capillary isoelectric focusing (cIEF) in general requires the use of reference points - markers of isoelectric point. The…”
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    Journal Article
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    Novel adamantane-bearing anilines and properties of their supramolecular complexes with β-cyclodextrin by Vícha, Robert, Rouchal, Michal, Kozubková, Zuzana, Kuřitka, Ivo, Marek, Radek, Branná, Petra, Čmelík, Richard

    Published in Supramolecular chemistry (01-10-2011)
    “…Several novel anilines bearing 1-adamantyl substituents that are useful for drug modification were synthesised from the corresponding 1-adamantyl (nitrophenyl)…”
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    Journal Article
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    Different behavior of dextrans in positive-ion and negative-ion mass spectrometry by CMELIK, Richard, STIKAROVSKA, Markéta, CHMELIK, Josef

    Published in Journal of mass spectrometry (01-12-2004)
    “…A mass spectrometric (MS) comparative study of dextran samples using two different ionization techniques (matrix‐assisted laser desorption/ionization (MALDI)…”
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    Journal Article Conference Proceeding
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    Labeling strategies for analysis of oligosaccharides and glycans by capillary electrophoresis by Smolkova, Denisa, Cmelik, Richard, Lavicka, Jana

    “…Capillary electrophoresis represents a powerful separation technique that has been widely accepted in oligosaccharide and glycan analysis. However, due to…”
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    Journal Article
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    No‐additive salting‐out liquid–liquid extraction—A tool for purification of positively charged compounds from highly salted reaction mixtures by Moravcová, Dana, Čmelík, Richard, Křenková, Jana

    Published in Journal of separation science (01-12-2020)
    “…A novel and original application of salting‐out assisted liquid–liquid extraction is presented. This technique was used to purify the final reaction products…”
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    Journal Article
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    Determination of short-term changes in levoglucosan and dehydroabietic acid in aerosols with Condensation Growth Unit – Aerosol Counterflow Two-Jets Unit – LC-MS by Coufalík, Pavel, Čmelík, Richard, Křůmal, Kamil, Čapka, Lukáš, Mikuška, Pavel

    Published in Chemosphere (Oxford) (01-11-2018)
    “…Residential areas in urban agglomerations and also in the countryside are often burdened with high concentrations of aerosol in winter, this originating from…”
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    Journal Article
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    Comparison of oligosaccharide labeling employing reductive amination and hydrazone formation chemistries by Krenkova, Jana, Dusa, Filip, Cmelik, Richard

    Published in Electrophoresis (01-05-2020)
    “…In this work, we compare labeling by two negatively charged fluorescent labels, 8‐aminopyrene‐1,3,6‐trisulfonic acid (APTS) and…”
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    Journal Article
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    Characterization of multi‐cationic aminopyrene‐based tag for oligosaccharide labeling by capillary electrophoresis with laser‐induced fluorescence detection by Krenkova, Jana, Dusa, Filip, Cmelik, Richard

    Published in Electrophoresis (01-07-2021)
    “…In this work, we characterize a previously synthesized multi‐cationic aminopyrene‐based labeling tag for oligosaccharide analysis by capillary electrophoresis…”
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    Journal Article
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    Synthesis and application of BODIPY-based fluorescent labeling tag for oligosaccharide and N-linked glycan analysis by high-performance liquid chromatography with fluorescence detection by Smolkova, Denisa, Gregus, Michal, Vesely, Hubert, Cmelik, Richard, Pizova, Hana, Bobal, Pavel, Lavicka, Jana

    Published in Analytica chimica acta (02-01-2024)
    “…Glycosylation analysis is still challenging, not only because of the extreme structure complexity and conjugation diversity of glycans but also because of…”
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    Journal Article
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    Multi-charged labeling of oligosaccharides and N-linked glycans by hexahistidine-based tags for capillary electrophoresis-mass spectrometry analysis by Partyka, Jan, Krenkova, Jana, Cmelik, Richard, Foret, Frantisek

    Published in Journal of Chromatography A (27-07-2018)
    “…•Derivatization of saccharides by hexahistidine tags was investigated.•Labeling reactions were performed by reductive amination and hydrazone…”
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    Journal Article
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    Multi-cationic aminopyrene-based labeling tags for oligosaccharide analysis by capillary electrophoresis-mass spectrometry by Krenkova, Jana, Liskova, Marcela, Cmelik, Richard, Vigh, Gyula, Foret, Frantisek

    Published in Analytica chimica acta (25-01-2020)
    “…In this work, new multi-cationic aminopyrene-based labeling tags were designed and synthesized for oligosaccharide analysis by capillary electrophoresis-mass…”
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    Journal Article
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    Structural analysis and differentiation of reducing and nonreducing neutral model starch oligosaccharides by negative-ion electrospray ionization ion-trap mass spectrometry by Čmelík, Richard, Chmelík, Josef

    Published in International journal of mass spectrometry (15-03-2010)
    “…The identification of nonreducing saccharides, as well as the differentiation between α-(1 → 4) and α-(1 → 6) linkage were obtained on the basis of presence of…”
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    Journal Article
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    Investigation of a side reaction occurring during N-linked glycan labeling by cationic tags by Krenkova, Jana, Bobal, Pavel, Partyka, Jan, Cmelik, Richard, Foret, Frantisek

    Published in Journal of Chromatography A (05-10-2018)
    “…•Positively labeled oligosaccharides and N-linked glycans were analyzed by CE-MS.•Several different labeling strategies were tested with different cationic…”
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    Journal Article
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    Separation of labeled isomeric oligosaccharides by hydrophilic interaction liquid chromatography – the role of organic solvent in manipulating separation selectivity of the amide stationary phase by Moravcová, Dana, Čmelík, Richard, Křenková, Jana

    Published in Journal of Chromatography A (16-08-2021)
    “…•HILIC separation of labeled isomeric oligosaccharides.•Increasing selectivity with alternative solvents.•Comparison for a representative set of labels and…”
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    Journal Article