Search Results - "Clynes, Raphael"

Redirected T Cell Cytotoxicity in Cancer Therapy by Clynes, Raphael A, Desjarlais, John R

“…Bispecific antibodies that recruit and redirect T cells to attack tumor cells have tremendous potential for the treatment of various malignancies. In general,…”
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Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation by Do, Catherine, Lang, Charles F., Lin, John, Darbary, Huferesh, Krupska, Izabela, Gaba, Aulona, Petukhova, Lynn, Vonsattel, Jean-Paul, Gallagher, Mary P., Goland, Robin S., Clynes, Raphael A., Dwork, Andrew, Kral, John G., Monk, Catherine, Christiano, Angela M., Tycko, Benjamin

“…Haplotype-dependent allele-specific methylation (hap-ASM) can impact disease susceptibility, but maps of this phenomenon using stringent criteria in…”
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Rapid skin repigmentation on oral ruxolitinib in a patient with coexistent vitiligo and alopecia areata (AA) by Harris, John E., MD, PhD, Rashighi, Mehdi, MD, Nguyen, Nhan, MD, Jabbari, Ali, MD, PhD, Ulerio, Grace, BA, Clynes, Raphael, MD, PhD, Christiano, Angela M., PhD, Mackay-Wiggan, Julian, MD, MS

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Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci by Betz, Regina C., Petukhova, Lynn, Ripke, Stephan, Huang, Hailiang, Menelaou, Androniki, Redler, Silke, Becker, Tim, Heilmann, Stefanie, Yamany, Tarek, Duvic, Madeliene, Hordinsky, Maria, Norris, David, Price, Vera H., Mackay-Wiggan, Julian, de Jong, Annemieke, DeStefano, Gina M., Moebus, Susanne, Böhm, Markus, Blume-Peytavi, Ulrike, Wolff, Hans, Lutz, Gerhard, Kruse, Roland, Bian, Li, Amos, Christopher I., Lee, Annette, Gregersen, Peter K., Blaumeiser, Bettina, Altshuler, David, Clynes, Raphael, de Bakker, Paul I. W., Nöthen, Markus M., Daly, Mark J., Christiano, Angela M.

“…Alopecia areata (AA) is a prevalent autoimmune disease with 10 known susceptibility loci. Here we perform the first meta-analysis of research on AA by…”
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Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease by Flynn, Ryan, Allen, Jessica L., Luznik, Leo, MacDonald, Kelli P., Paz, Katelyn, Alexander, Kylie A., Vulic, Ante, Du, Jing, Panoskaltsis-Mortari, Angela, Taylor, Patricia A., Poe, Jonathan C., Serody, Jonathan S., Murphy, William J., Hill, Geoffrey R., Maillard, Ivan, Koreth, John, Cutler, Corey S., Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome, Chao, Nelson J., Clynes, Raphael A., Sarantopoulos, Stefanie, Blazar, Bruce R.

“…Novel therapies for chronic graft-versus-host disease (cGVHD) are needed. Aberrant B-cell activation has been demonstrated in mice and humans with cGVHD…”
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Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib by Jabbari, Ali, Dai, Zhenpeng, Xing, Luzhou, Cerise, Jane E., Ramot, Yuval, Berkun, Yackov, Sanchez, Gina A. Montealegre, Goldbach-Mansky, Raphaela, Christiano, Angela M., Clynes, Raphael, Zlotogorski, Abraham

“…Alopecia areata (AA) is an autoimmune disease resulting in hair loss with devastating psychosocial consequences. Despite its high prevalence, there are no…”
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Cell Surface Recycling of Internalized Antigen Permits Dendritic Cell Priming of B Cells by Bergtold, Amy, Desai, Dharmesh D., Gavhane, Anamika, Clynes, Raphael

“…Dendritic cells process internalized antigens to present degradative products on MHC for TCR recognition. Because antigen-exposed DCs also induce humoral…”
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Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets by Ravetch, Jeffrey V, Clynes, Raphael A, Towers, Terri L, Presta, Leonard G

“…Inhibitory receptors have been proposed to modulate the in vivo cytotoxic response against tumor targets for both spontaneous and antibody-dependent pathways…”
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Pharmacologic inhibition of JAK-STAT signaling promotes hair growth by Harel, Sivan, Higgins, Claire A, Cerise, Jane E, Dai, Zhenpeng, Chen, James C, Clynes, Raphael, Christiano, Angela M

“…Several forms of hair loss in humans are characterized by the inability of hair follicles to enter the growth phase (anagen) of the hair cycle after being…”
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RAGE expression in human T cells: a link between environmental factors and adaptive immune responses by Akirav, Eitan M, Preston-Hurlburt, Paula, Garyu, Justin, Henegariu, Octavian, Clynes, Raphael, Schmidt, Ann Marie, Herold, Kevan C

“…The Receptor for Advanced Glycation Endproducts (RAGE) is a scavenger ligand that binds glycated endproducts as well as molecules released during cell death…”
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Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells by Chang, Chih-Chao, Zhang, Qing-Yin, Liu, Zhuoru, Clynes, Raphael A, Suciu-Foca, Nicole, Vlad, George

“…We have investigated the mechanism underlying the immunoregulatory function of membrane Ig-like transcript 3 (ILT3) and soluble ILT3Fc. microRNA (miRNA)…”
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Augmented HER-2–Specific Immunity during Treatment with Trastuzumab and Chemotherapy by TAYLOR, Clare, HERSHMAN, Dawn, CLYNES, Raphael, SHAH, Nina, SUCIU-FOCA, Nicole, PETRYLAK, Dan P, TAUB, Robert, VAHDAT, Linda, BIN CHENG, PEGRAM, Mark, KNUTSON, Keith L

“…Purpose: Passive immunotherapy with antitumor antibodies has the potential to induce active tumor immunity via the opsonic enhancement of immunogenicity of…”
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Molecular signatures define alopecia areata subtypes and transcriptional biomarkers by Jabbari, Ali, Cerise, Jane E., Chen, James C., Mackay-Wiggan, Julian, Duvic, Madeleine, Price, Vera, Hordinsky, Maria, Norris, David, Clynes, Raphael, Christiano, Angela M.

“…Alopecia areata (AA) is an autoimmune disease typified by nonscarring hair loss with a variable clinical course. In this study, we conducted whole genome gene…”
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The receptor for advanced glycation end products (RAGE) affects T cell differentiation in OVA induced asthma by Akirav, Eitan M, Henegariu, Octavian, Preston-Hurlburt, Paula, Schmidt, Ann Marie, Clynes, Raphael, Herold, Kevan C

“…The receptor for glycation end products (RAGE) has been previously implicated in shaping the adaptive immune response. RAGE is expressed in T cells after…”
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FcR-Bearing Myeloid Cells Are Responsible for Triggering Murine Lupus Nephritis by Bergtold, Amy, Gavhane, Anamika, D'Agati, Vivette, Madaio, Michael, Clynes, Raphael

“…Lupus glomerulonephritis is initiated by deposition of IgG-containing immune complexes in renal glomeruli. FcR engagement by immune complexes (IC) is crucial…”
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Generation of HER2-specific antibody immunity during trastuzumab adjuvant therapy associates with reduced relapse in resected HER2 breast cancer by Norton, Nadine, Fox, Nicholas, McCarl, Christie-Ann, Tenner, Kathleen S, Ballman, Karla, Erskine, Courtney L, Necela, Brian M, Northfelt, Donald, Tan, Winston W, Calfa, Carmen, Pegram, Mark, Colon-Otero, Gerardo, Perez, Edith A, Clynes, Raphael, Knutson, Keith L

“…Resected HER2 breast cancer patients treated with adjuvant trastuzumab and chemotherapy have superior survival compared to patients treated with chemotherapy…”
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Receptor for advanced glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress by Herold, Kevan, Moser, Bernhard, Chen, Yali, Zeng, Shan, Yan, Shi Fang, Ramasamy, Ravichandran, Emond, Jean, Clynes, Raphael, Schmidt, Ann Marie

“…The multiligand receptor for advanced glycation end products (RAGE) of the Ig superfamily transduces the biological impact of discrete families of ligands,…”
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Therapeutic targeting of Syk in autoimmune diabetes by Colonna, Lucrezia, Catalano, Geoffrey, Chew, Claude, D'Agati, Vivette, Thomas, James W, Wong, F Susan, Schmitz, Jochen, Masuda, Esteban S, Reizis, Boris, Tarakhovsky, Alexander, Clynes, Raphael

“…In APCs, the protein tyrosine kinase Syk is required for signaling of several immunoreceptors, including the BCR and FcR. We show that conditional ablation of…”
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764 A phase 1, first-in-human (FIH), open-label, dose-finding and expansion study of XmAb808, a B7H3 x CD28 bispecific antibody, in combination with pembrolizumab in patients with advanced solid tumors by Bupathi, Manojkumar, Wang, Judy S, Hu-Lieskovan, Siwen, Piha-Paul, Sarina A, Chmielowski, Bartosz, Garmezy, Benjamin, Najjar, Yana G, Stein, Mark N, Yao, Li, Kanodia, Jitendra, Clynes, Raphael, McGovern, Patricia, Thompson, Benjamin

“…BackgroundB7H3 is preferentially expressed by many solid tumors, making it an attractive therapeutic target. XmAb808 is a fully human B7H3 x CD28 bispecific…”
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B cell therapy is β-tested: Rituximab puts a pause on β-cell destruction by Clynes, Raphael

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