Search Results - "Clynes, R."

An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis by Jabbari, A., Sansaricq, F., Cerise, J., Chen, J.C., Bitterman, A., Ulerio, G., Borbon, J., Clynes, R., Christiano, A.M., Mackay-Wiggan, J.

“…Alopecia areata (AA) is a common autoimmune disease with a lifetime risk of ∼2%. In AA, the immune system targets the hair follicle, resulting in clinical hair…”
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A Type 1 Diabetes Genetic Risk Score Predicts Progression of Islet Autoimmunity and Development of Type 1 Diabetes in Individuals at Risk by Redondo, Maria J, Geyer, Susan, Steck, Andrea K, Sharp, Seth, Wentworth, John M, Weedon, Michael N, Antinozzi, Peter, Sosenko, Jay, Atkinson, Mark, Pugliese, Alberto, Oram, Richard A

“…We tested the ability of a type 1 diabetes (T1D) genetic risk score (GRS) to predict progression of islet autoimmunity and T1D in at-risk individuals. We…”
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PB2102: PHASE 2 RANDOMIZED, OPEN‐LABEL, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PLAMOTAMAB COMBINED WITH TAFASITAMAB (TAFA) + LENALIDOMIDE (LEN) VS TAFA+LEN IN RELAPSED OR REFRACTORY DLBCL by Michot, J.‐M., Koh, Y., Lee, P., Jin, J., Clynes, R., Kye, S., Chiarella, M., Patel, K.

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DIVERGENT ROLES FOR Fc RECEPTORS AND COMPLEMENT IN VIVO by Ravetch, Jeffrey V, Clynes, Raphael A

“…Recent results obtained in mice deficient in either FcRs or complement have revealed distinct functions for these two classes of molecules. While each is…”
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Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice by Sylvestre, D, Clynes, R, Ma, M, Warren, H, Carroll, M C, Ravetch, J V

“…The role of complement in immunoglobulin G-triggered inflammation was studied in mice genetically deficient in complement components C3 and C4. Using the…”
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Protective mechanisms of IVIG by Clynes, Raphael

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022 Enhancing the vaccinal effect of anti-tumor antibodies in melanoma by Perez-Lorenzo, R., Christiano, A.M., Clynes, R.

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1210 Enhancing the therapeutic efficacy of immune checkpoint inhibition and targeted therapy using anti-tumor antibodies in mouse melanoma by Perez-Lorenzo, R., Erjavec, S., Clynes, R., Christiano, A.M.

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054 Regulatory natural killer cells are protective in alopecia areata by Clynes, R., Dai, Z., Cerise, J., Christiano, A.M.

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Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes by Haller, Michael J., Schatz, Desmond A., Skyler, Jay S., Krischer, Jeffrey P., Bundy, Brian N., Miller, Jessica L., Atkinson, Mark A., Becker, Dorothy J., Baidal, David, DiMeglio, Linda A., Gitelman, Stephen E., Goland, Robin, Gottlieb, Peter A., Herold, Kevan C., Marks, Jennifer B., Moran, Antoinette, Rodriguez, Henry, Russell, William, Wilson, Darrell M., Greenbaum, Carla J., Greenbaum, C., Atkinson, M., Baidal, D., Battaglia, M., Becker, D., Bingley, P., Bosi, E., Buckner, J., Clements, M., Colman, P., DiMeglio, L., Evans-Molina, C., Gitelman, S., Goland, R., Gottlieb, P., Herold, K., Knip, M., Krischer, J., Lernmark, A., Moore, W., Moran, A., Muir, A., Palmer, J., Peakman, M., Philipson, L., Raskin, P., Redondo, M., Rodriguez, H., Russell, W., Spain, L., Schatz, D.A., Sosenko, J., Wherrett, D., Wilson, D., Winter, W., Ziegler, A., Anderson, M., Antinozzi, P., Benoist, C., Blum, J., Bourcier, K., Chase, P., Clare-Salzler, M., Clynes, R., Cowie, C., Eisenbarth, G., Fathman, C.G., Grave, G., Harrison, L., Hering, B., Insel, R., Jordan, S., Kaufman, F., Kay, T., Kenyon, N., Klines, R., Lachin, J., Leschek, E., Mahon, J., Marks, J.B., Monzavi, R., Nanto-Salonen, K., Nepom, G., Orban, T., Parkman, R., Pescovitz, M., Peyman, J., Pugliese, A., Ridge, J., Roep, B., Roncarolo, M., Savage, P., Simell, O., Sherwin, R., Siegelman, M., Skyler, J.S., Steck, A., Thomas, J., Trucco, M., Wagner, J.

“…OBJECTIVE A pilot study suggested that combination therapy with low-dose anti-thymocyte globulin (ATG) and pegylated granulocyte colony-stimulating factor…”
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Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes: A Randomized Clinical Trial by Krischer, Jeffrey P, Schatz, Desmond A, Bundy, Brian, Skyler, Jay S, Greenbaum, Carla J

“…IMPORTANCE: Type 1 diabetes requires major lifestyle changes and carries increased morbidity and mortality. Prevention or delay of diabetes would have major…”
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Immune complexes as therapy for autoimmunity by Clynes, Raphael

“…For several decades, intravenous Ig has been used as treatment for a variety of immune-related diseases, including immune thrombocytopenic purpura (ITP),…”
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042 Alopecia areata reversal by il-7ra blockade via upregulation of the pd-1 signaling pathway by Dai, Z., Cerise, J., Petukhova, L., Clynes, R., Christiano, A.M.

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455 Molecular correlation with clinical outcomes in an open label clinical trial of oral tofacitinib in patients with alopecia areata by Bitterman, A., Jabbari, A., Chen, J., de Jong, A., Clynes, R., Mackay-Wiggan, J., Christiano, A.

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786 Quantitative visualization of immune infiltrates by multispectral imaging as predictive biomarkers in melanoma by Jazwinska, D., Pérez-Lorenzo, R., Gartrell, R., Clynes, R., Saenger, Y., Christiano, A.M.

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050 Alopecia areata is reversed by IL-7Rα blockade via upregulation of the PD-1 signaling pathway by Dai, Z., Cerise, J., Chen, J., Petukhova, L., de Jong, A., Clynes, R., Christiano, A.M.

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331 An open label clinical trial of the JAK inhibitor tofacitinib for alopecia areata by Jabbari, A., Cerise, J., Chen, J.C., Sansaricq, F., Clynes, R., Christiano, A.M., Mackay-Wiggan, J.

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320 An open label clinical trial of Abatacept (CTLA4-Ig) for alopecia areata by Sansaricq, F., Mackay-Wiggan, J., Jabbari, A., Christiano, A.M., Clynes, R.

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397 Predictive modeling of drug response and mechanism of action in alopecia areata clinical trials by Chen, J.C., Jabbari, A., Clynes, R., Mackay-Wiggin, J., Christiano, A.M.

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043 Regulatory natural killer cells in alopecia areata by Dai, Z., Cerise, J., de Jong, A., Clynes, R., Christiano, A.M.

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