Search Results - "Clyne, Alisa"

Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation by Buyukhatipoglu, Kivilcim, Clyne, Alisa Morss

“…Superparamagnetic iron oxide nanoparticles are used in various medical applications including magnetic resonance imaging, magnetic hyperthermia, and targeted…”
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Biofabrication strategies for creating microvascular complexity by Morss Clyne, Alisa, Swaminathan, Swathi, Díaz Lantada, Andrés

“…Design and fabrication of effective biomimetic vasculatures constitutes a relevant and yet unsolved challenge, lying at the heart of tissue repair and…”
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An inverted dielectrophoretic device for analysis of attached single cell mechanics by Lownes Urbano, Rebecca, Morss Clyne, Alisa

“…Dielectrophoresis (DEP), the force induced on a polarizable body by a non-uniform electric field, has been widely used to manipulate single cells in suspension…”
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Hydroxyl Radical and Hydrogen Peroxide are Primarily Responsible for Dielectric Barrier Discharge Plasma-Induced Angiogenesis by Priya Arjunan, Krishna, Morss Clyne, Alisa

“…Non‐thermal plasmas have recently been applied to biomedical challenges, including blood coagulation, sterilization and malignant cell apoptosis. We previously…”
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Preclinical techniques to investigate exercise training in vascular pathophysiology by Sangha, Gurneet S, Goergen, Craig J, Prior, Steven J, Ranadive, Sushant M, Clyne, Alisa M

“…Atherosclerosis is a dynamic process starting with endothelial dysfunction and inflammation and eventually leading to life-threatening arterial plaques…”
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Mechanical stimuli such as shear stress and piezo1 stimulation generate red blood cell extracellular vesicles by Sangha, Gurneet S, Weber, Callie M, Sapp, Ryan M, Setua, Saini, Thangaraju, Kiruphagaran, Pettebone, Morgan, Rogers, Stephen C, Doctor, Allan, Buehler, Paul W, Clyne, Alisa M

“…Generating physiologically relevant red blood cell extracellular vesicles (RBC-EVs) for mechanistic studies is challenging. Herein, we investigated how to…”
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Dextran and polymer polyethylene glycol (PEG) coating reduce both 5 and 30 nm iron oxide nanoparticle cytotoxicity in 2D and 3D cell culture by Yu, Miao, Huang, Shaohui, Yu, Kevin Jun, Clyne, Alisa Morss

“…Superparamagnetic iron oxide nanoparticles are widely used in biomedical applications, yet questions remain regarding the effect of nanoparticle size and…”
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Endothelial Cell Proliferation is Enhanced by Low Dose Non-Thermal Plasma Through Fibroblast Growth Factor-2 Release by Kalghatgi, Sameer, Friedman, Gary, Fridman, Alexander, Clyne, Alisa Morss

“…Non-thermal dielectric barrier discharge plasma is being developed for a wide range of medical applications, including wound healing, blood coagulation, and…”
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Targeted siRNA Nanoparticles for Mammary Carcinoma Therapy by Ben-David-Naim, Meital, Dagan, Arie, Grad, Etty, Aizik, Gil, Nordling-David, Mirjam M, Morss Clyne, Alisa, Granot, Zvi, Golomb, Gershon

“…Non-viral, polymeric-based, siRNA nanoparticles (NPs) have been proposed as promising gene delivery systems. Encapsulating siRNA in targeted NPs could confer…”
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Stiff Substrates Increase Inflammation-Induced Endothelial Monolayer Tension and Permeability by Urbano, Rebecca Lownes, Furia, Christina, Basehore, Sarah, Clyne, Alisa Morss

“…Arterial stiffness and inflammation are associated with atherosclerosis, and each have individually been shown to increase endothelial monolayer tension and…”
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Non-thermal dielectric barrier discharge plasma induces angiogenesis through reactive oxygen species by Arjunan, Krishna Priya, Friedman, Gary, Fridman, Alexander, Clyne, Alisa Morss

“…Vascularization plays a key role in processes such as wound healing and tissue engineering. Non-thermal plasma, which primarily produces reactive oxygen…”
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Sex differences in the blood–brain barrier and neurodegenerative diseases by Weber, Callie M., Clyne, Alisa Morss

“…The number of people diagnosed with neurodegenerative diseases is on the rise. Many of these diseases, including Alzheimer's disease, Parkinson's disease,…”
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Steady Laminar Flow Decreases Endothelial Glycolytic Flux While Enhancing Proteoglycan Synthesis and Antioxidant Pathways by Basehore, Sarah E, Garcia, Jonathan, Clyne, Alisa Morss

“…Endothelial cells in steady laminar flow assume a healthy, quiescent phenotype, while endothelial cells in oscillating disturbed flow become dysfunctional…”
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Quantification of Multicellular Organization, Junction Integrity, and Substrate Features in Collective Cell Migration by Canver, Adam C, Morss Clyne, Alisa

“…Quantitative analysis of multicellular organization, cell-cell junction integrity, and substrate properties is essential to understand the mechanisms…”
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Fibroblast Growth Factor-2 Binding to Heparan Sulfate Proteoglycans Varies with Shear Stress in Flow-Adapted Cells by Garcia, Jonathan, Patel, Nisha, Basehore, Sarah, Clyne, Alisa Morss

“…Fibroblast growth factor 2 (FGF2), an important regulator of angiogenesis, binds to endothelial cell (EC) surface FGF receptors (FGFRs) and heparan sulfate…”
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Glycated collagen alters endothelial cell actin alignment and nitric oxide release in response to fluid shear stress by Kemeny, Steven F, Figueroa, Dannielle S, Andrews, Allison M, Barbee, Kenneth A, Clyne, Alisa Morss

“…Abstract People with diabetes suffer from early accelerated atherosclerosis, which contributes to morbidity and mortality from myocardial infarction, stroke,…”
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Hypo- and hyperglycemia impair endothelial cell actin alignment and nitric oxide synthase activation in response to shear stress by Kemeny, Steven Frank, Figueroa, Dannielle Solomon, Clyne, Alisa Morss

“…Uncontrolled blood glucose in people with diabetes correlates with endothelial cell dysfunction, which contributes to accelerated atherosclerosis and…”
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Endothelial directed collective migration depends on substrate stiffness via localized myosin contractility and cell-matrix interactions by Canver, Adam Charles, Ngo, Olivia, Urbano, Rebecca Lownes, Clyne, Alisa Morss

“…Abstract Macrovascular endothelial injury, which may be caused by percutaneous intervention, requires endothelial cell directed collective migration to restore…”
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A Three-Dimensional In Vitro Coculture Model to Quantify Breast Epithelial Cell Adhesion to Endothelial Cells by Swaminathan, Swathi, Cranston, Aaron N, Clyne, Alisa Morss

“…Three-dimensional (3D) culture models better recapitulate the tissue microenvironment, and therefore may provide a better platform to evaluate therapeutic…”
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Human Pulmonary Artery Endothelial Cells Increased Glycolysis and Decreased Nitric Oxide Synthase O-GlcNAcylation in Pulmonary Arterial Hypertension by Basehore, Sarah E., Clyne, Alisa Morss

“…Pulmonary arterial hypertension (PAH) is a fatal disease that primarily affects women. In PAH, endothelial cells become dysfunctional, reducing production of…”
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