Search Results - "Clutterbuck, R D"

A bioinformatic screen for novel A–I RNA editing sites reveals recoding editing in BC10 by Clutterbuck, D. R., Leroy, A., O'Connell, M. A., Semple, C. A. M.

“…Motivation: Recent studies have demonstrated widespread adenosine–inosine RNA editing in non-coding sequence. However, the extent of editing in coding…”
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Inhibitory effect of simvastatin on the proliferation of human myeloid leukaemia cells in severe combined immunodeficient (SCID) mice by Clutterbuck, Robyn D., Millar, Barbara C., Powles, Ray L., Newman, Ann, Catovsky, Daniel, Jarman, Michael, Millar, John L.

“…SCID mice were inoculated intravenously with cells from the human HL60 myeloblastic leukaemia cell line and then treated with the 3‐hydroxy‐3‐methylglutaryl…”
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Deletions and Rearrangement of CDKN2 in Lymphoid Malignancy by Stranks, G., Height, S.E., Mitchell, P., Jadayel, D., Yuille, M.A.R., De Lord, C., Clutterbuck, R.D., Treleaven, J.G., Powles, R.L., Nacheva, E., Oscier, D.G., Karpas, A., Lenoir, G.M., Smith, S.D., Millar, J.L., Catovsky, D., Dyer, M.J.S.

“…Recurrent abnormalities of the short arm of chromosome 9, including translocations and interstitial deletions, have been reported in both leukemia and…”
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Selective inhibition of primary acute myeloid leukaemia cell growth by lovastatin by Newman, A, Clutterbuck, R D, Powles, R L, Millar, J L

“…Primary human acute myeloid leukaemic (AML) cells from bone marrow (BM) and peripheral blood (PB), the human myeloblastic leukaemia cell line (HL60) and normal…”
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G-CSF mobilization of haemopoietic cell populations in SCID mice engrafted with human leukaemia by CLUTTERBUCK, R. D, NEWMAN, A, POWLES, R, CATOVSKY, D, MILLAR, J. L

“…We have studied granulocyte colony-stimulating factor (G-CSF)-induced mobilization of haemopoietic cells in severe combined immune-deficient (SCID) mice…”
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Growth of human T-cell lineage acute leukemia in severe combined immunodeficiency (SCID) mice and non-obese diabetic SCID mice by STEELE, J. P. C, CLUTTERBUCK, R. D, POWLES, R. L, MITCHELL, P. L. R, HORTON, C, MORILLA, R, CATOVSKY, D, MILLAR, J. L

“…Primary leukemic cells from patients with acute lymphoblastic leukemia (ALL) can be injected intravenously into mice with severe combined immunodeficiency…”
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Human Philadelphia chromosome-positive chronic myeloid leukemia: a potential model for antisense therapy by De Lord, C, Clutterbuck, R D, Powles, R L, Min, T, Titley, J C, Millar, J L

“…We have developed an in vivo model of human chronic myeloid leukemia (CML). A peripheral blood (PB) sample of Philadelphia (Ph) chromosome-positive CML cells…”
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Interleukin-4 Enhances the Survival of Severe Combined Immunodeficient Mice Engrafted With Human B-Cell Precursor Leukemia by Mitchell, Paul L.R., Clutterbuck, Robyn D., Powles, Ray L., De Lord, Corinne, Morilla, Ricardo, Hiorns, Lynne R., Titley, Jennifer, Catovsky, Daniel, Millar, John L.

“…Human interleukin-4 (hulL-4) has been shown to inhibit the growth in vitro of cells from patients with acute lymphoblastic leukemia (ALL). With the aim of…”
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The response of human myeloid leukaemia xenografts to human recombinant tumour necrosis factor by CLUTTERBUCK, R. D, POWLES, R. L, MILLAR, J. L

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Verapamil potentiation of melphalan cytotoxicity and cellular uptake in murine fibrosarcoma and bone marrow by ROBINSON, B. A, CLUTTERBUCK, R. D, MILLAR, J. L, MCELWAIN, T. J

“…Growth delay by melphalan of two fibrosarcomas in CBA mice was prolonged by intraperitoneal (i.p.) verapamil, 10 mg kg-1. Verapamil also increased the area…”
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The sensitivity of leukemic bone marrow to simvastatin is lost at remission: a potential purging agent for autologous bone marrow transplantation by Newman, A, Clutterbuck, R D, DeLord, C, Powles, R L, Catovsky, D, Millar, J L

“…Autologous bone marrow transplantation (ABMT) is frequently used in the treatment of malignant disease but carries the risk of reintroducing tumor cells into…”
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Growth of xenografted human bone marrow: comparison with hemopoietic reconstitution in patients after allogeneic bone marrow transplant and response to granulocyte macrophage colony stimulating factor by Clutterbuck, R D, Clarke, D, Powles, R L, Millar, J L

“…Normal human bone marrow was grown as xenografts in mice immune-suppressed by thymectomy and total body irradiation. Mononuclear cell fractions isolated from…”
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Epidermal growth factor (hEGF) has no effect on murine intestine epithelial damage and regeneration after melphalan by ROBINSON, B. A, CLUTTERBUCK, R. D, MILLAR, J. L, MCELWAIN, T. J

“…The effect of epidermal growth factor (hEGF) on intestinal epithelial damage by melphalan was explored in CBA mice. Human EGF was administered in doses of 100…”
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Effects of verapamil and alcohol on blood flow, melphalan uptake and cytotoxicity, in murine fibrosarcomas and human melanoma xenografts by ROBINSON, B. A, CLUTTERBUCK, R. D, MILLAR, J. L, MCELWAIN, T. J

“…Verapamil had previously been shown to increase cellular melphalan uptake and cytotoxicity in fibrosarcomas, and increased the area under the blood…”
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Transcriptional Landscape of the Mammalian Genome by Carninci, P, Kasukawa, T, Katayama, S, Gough, J, Frith, M. C, Maeda, N, Oyama, R, Lenhard, B, Wells, C, Bajic, V. B, Brenner, S. E, Batalov, S, Forrest, A. R. R, Zavolan, M, Wilming, L. G, Ambesi-Impiombato, A, Aturaliya, R. N, Bailey, T. L, Bansal, M, Baxter, L, Beisel, K. W, Bono, H, Chalk, A. M, Chiu, K. P, Christoffels, A, Dalla, E, Dalrymple, B. P, de Bono, B, Down, T, Engstrom, P, Fagiolini, M, Faulkner, G, Furuno, M, Gingeras, T. R, Gojobori, T, Gustincich, S, Harbers, M, Hensch, T. K, Hirokawa, N, Hill, D, Ikeo, K, Ishikawa, T, Jakt, M, Kanapin, A, Katoh, M, Kawasawa, Y, Kitano, H, Kollias, G, Kurochkin, I. V, Lareau, L. F, Liu, J, Liuni, S, Madera, M, Matsuda, H, Matsuzawa, S, Morris, K, Nakano, N, Nishiguchi, S, Nishikawa, S, Nori, F, Pesole, G, Reed, J, Ruan, Y, Salzberg, S. L, Schneider, C, Sekiguchi, K, Semple, C. A. M, Sessa, L, Sheng, Y, Shibata, Y, Shimada, K, Sinclair, B, Sperling, S, Sultana, R, Taki, K, Ueda, H. R, Wei, C. L, Yamanishi, H, Zabarovsky, E, Zhu, S, Hide, W, Bult, C, Teasdale, R. D, Liu, E. T, Mattick, J. S, Hume, D. A, Kai, C, Sasaki, D, Kanamori-Katayama, M, Suzuki, M, Imamura, K, Itoh, M, Kato, T, Kawagashira, N, Nakano, K, Ninomiya, N, Okada, M, Suzuki, S, Watahiki, A, Kawai, J

“…This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs…”
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Failure of high doses of α interferon to affect the growth of human carcinoma, melanoma, and myeloid leukaemia xenografts by CLUTTERBUCK, R. D, MILLAR, J. L, ALEXANDER, P

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Prevention of acute deaths in mice after very high dose cyclophosphamide by divided dose schedule by EVANS, B. D, SMITH, I. E, CLUTTERBUCK, R. D, MILLAR, J. L

“…Very high dose cyclophosphamide (Cy) (500-600 mg kg-1) given by single bolus i.p. injection in mice caused acute deaths in all animals within 48 h of treatment…”
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A Comparison of the Effect of the 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors Simvastatin, Lovastatin and Pravastatin on Leukaemic and Normal Bone Marrow Progenitors by Newman, Ann, Clutterbuck, Robyn D., Powles, Ray L., Catovsky, Daniel, Millar, John L.

“…Simvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and also selectively inhibits the growth of leukaemic progenitor…”
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The modification of melphalan toxicity in tumor bearing mice by s-2-(3-aminopropylamino)- ethylphosphorothioic acid (WR 2721) by Millar, J L, McElwain, T J, Clutterbuck, R D, Wist, E A

“…The toxicity of melphalan in mice was reduced by the injection of S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR2721). This was seen in terms of…”
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Liposomal vincristine for the treatment of human acute lymphoblastic leukaemia in severe combined immunodeficient (SCID) mice by MILLAR, J. L, MILLAR, B. C, POWLES, R. L, STEELE, J. P. C, CLUTTERBUCK, R. D, MITCHELL, P. L. R, COX, G, FORSSEN, E, CATOVSKY, D

“…Non-obese diabetic NOD/SCID mice have been used to grow human leukaemia as a systemic disease. The animals were inoculated with leukaemic cells obtained from a…”
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