Search Results - "Cluderay, Jane E."

GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models by Medhurst, Andrew D, Atkins, Alan R, Beresford, Isabel J, Brackenborough, Kim, Briggs, Michael A, Calver, Andrew R, Cilia, Jackie, Cluderay, Jane E, Crook, Barry, Davis, John B, Davis, Rebecca K, Davis, Robert P, Dawson, Lee A, Foley, Andrew G, Gartlon, Jane, Gonzalez, M Isabel, Heslop, Teresa, Hirst, Warren D, Jennings, Carol, Jones, Declan N C, Lacroix, Laurent P, Martyn, Abbe, Ociepka, Sandrine, Ray, Alison, Regan, Ciaran M, Roberts, Jennifer C, Schogger, Joanne, Southam, Eric, Stean, Tania O, Trail, Brenda K, Upton, Neil, Wadsworth, Graham, Wald, Jeffrey A, White, Trevor, Witherington, Jason, Woolley, Marie L, Worby, Angela, Wilson, David M

“…6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) is a novel histamine H(3) receptor…”
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In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia by Dawson, Lee A, Cato, Katherine J, Scott, Claire, Watson, Jeannette M, Wood, Martyn D, Foxton, Richard, de la Flor, Raúl, Jones, Gareth A, Kew, James Nc, Cluderay, Jane E, Southam, Eric, Murkitt, Graham S, Gartlon, Jane, Pemberton, Darrel J, Jones, Declan Nc, Davies, Ceri H, Hagan, Jim

“…Neurokinin-3 (NK3) receptors are concentrated in forebrain and basal ganglia structures within the mammalian CNS. This distribution, together with the…”
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Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040 by Southam, Eric, Cilia, Jackie, Gartlon, Jane E., Woolley, Marie L., Lacroix, Laurent P., Jennings, Carol A., Cluderay, Jane E., Reavill, Charlie, Rourke, Claire, Wilson, David M., Dawson, Lee A., Medhurst, Andrew D., Jones, Declan N. C.

“…Objectives To test the novel nonimidazole histamine H 3 receptor antagonist 5-[(3-cyclobutyl-2,3,4,5-tetrahydro-1 H -3-benzazapin-7-yl)oxy]- N…”
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Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation by Turnock-Jones, Julia J., Jennings, Carol A., Robbins, Melanie J., Cluderay, Jane E., Cilia, Jackie, Reid, Juliet L., Taylor, Adam, Jones, Declan N.C., Emson, Piers C., Southam, Eric

“…A hypofunction of the N‐methyl‐D‐aspartate (NMDA) receptor has been implicated in the pathophysiology of schizophrenia. Compelling evidence of altered NMDA…”
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Reversal of isolation-rearing-induced PPI deficits by an α7 nicotinic receptor agonist by CILIA, Jackie, CLUDERAY, Jane E, ROBBINS, Melanie J, REAVILL, Charlie, SOUTHAM, Eric, KEW, James N. C, JONES, Declan N. C

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Effect of the selective dopamine D3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain by Southam, Eric, Lloyd, Andrew, Jennings, Carol A, Cluderay, Jane E, Cilia, Jackie, Gartlon, Jane E, Jones, Declan N.C

“…Abstract SB-277011-A is a dopamine D3 receptor antagonist that exhibits over 100-fold selectivity over dopamine D2 receptors and a broad spectrum of other…”
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In vitro and in vivo comparison of two non-peptide tachykinin NK3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics by DAWSON, Lee A, LANGMEAD, Christopher J, HILL, Mark D, JONES, Declan N. C, DAVIES, Ceri H, HAGAN, Jim J, SMITH, Paul W, DADA, Adeshola, WATSON, Jeannette M, ZINING WU, DE LA FLOR, Raúl, JONES, Gareth A, CLUDERAY, Jane E, SOUTHAM, Eric, MURKITT, Graham S

“…Clinical evaluation of tachykinin NK(3) receptor antagonists has provided support for the therapeutic utility of this target in schizophrenia. However, these…”
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Reversal of isolation-rearing-induced PPI deficits by an alpha 7 nicotinic receptor agonist by Cilia, Jackie, Cluderay, Jane E, Robbins, Melanie J, Reavill, Charlie, Southam, Eric, Kew, James NC, Jones, Declan NC

“…Rationale: The alpha 7 subtype of the nicotinic receptor plays an important role in auditory sensory gating. Schizophrenics show deficient sensory gating and…”
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Effect of the selective dopamine D 3 receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain by Southam, Eric, Lloyd, Andrew, Jennings, Carol A., Cluderay, Jane E., Cilia, Jackie, Gartlon, Jane E., Jones, Declan N.C.

“…SB-277011-A is a dopamine D 3 receptor antagonist that exhibits over 100-fold selectivity over dopamine D 2 receptors and a broad spectrum of other receptor,…”
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In vitro and in vivo comparison of two non-peptide tachykinin NK sub(3) receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics by Dawson, Lee A, Langmead, Christopher J, Dada, Adeshola, Watson, Jeannette M, Wu, Zining, De la Flor, Raul, Jones, Gareth A, Cluderay, Jane E, Southam, Eric, Murkitt, Graham S, Hill, Mark D, Jones, Declan NC, Davies, Ceri H, Hagan, Jim J, Smith, Paul W

“…Clinical evaluation of tachykinin NK sub(3) receptor antagonists has provided support for the therapeutic utility of this target in schizophrenia. However,…”
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In vitro and in vivo comparison of two non-peptide tachykinin NK 3 receptor antagonists: Improvements in efficacy achieved through enhanced brain penetration or altered pharmacological characteristics by Dawson, Lee A., Langmead, Christopher J., Dada, Adeshola, Watson, Jeannette M., Wu, Zining, de la Flor, Raúl, Jones, Gareth A., Cluderay, Jane E., Southam, Eric, Murkitt, Graham S., Hill, Mark D., Jones, Declan N.C., Davies, Ceri H., Hagan, Jim J., Smith, Paul W.

“…Clinical evaluation of tachykinin NK 3 receptor antagonists has provided support for the therapeutic utility of this target in schizophrenia. However, these…”
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Reversal of isolation-rearing-induced PPI deficits by an alpha7 nicotinic receptor agonist by Cilia, Jackie, Cluderay, Jane E, Robbins, Melanie J, Reavill, Charlie, Southam, Eric, Kew, James N C, Jones, Declan N C

“…The alpha7 subtype of the nicotinic receptor plays an important role in auditory sensory gating. Schizophrenics show deficient sensory gating and abnormalities…”
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Reversal of isolation-rearing-induced PPI deficits by an [alpha]7 nicotinic receptor agonist by Cilia, Jackie, Cluderay, Jane E, Robbins, Melanie J, Reavill, Charlie, Southam, Eric, Kew, James N C, Jones, Declan N C

“…The alpha7 subtype of the nicotinic receptor plays an important role in auditory sensory gating. Schizophrenics show deficient sensory gating and abnormalities…”
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In Vitro and In Vivo Characterization of the Non-peptide N K3 Receptor Antagonist SB-223412 (Talnetant) : Potential Therapeutic Utility in the Treatment of Schizophrenia by DAWSON, Lee A, CATO, Katherine J, SOUTHAM, Eric, MURKITT, Graham S, GARTLON, Jane, PEMBERTON, Darrel J, JONES, Declan N. C, DAVIES, Ceri H, HAGAN, Jim, SCOTT, Claire, WATSON, Jeannette M, WOOD, Martyn D, FOXTON, Richard, DE LA FLOR, Raul, JONES, Gareth A, KEW, James N. C, CLUDERAY, Jane E

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