Search Results - "Clubb, R T"

Demonstration of Positionally Disordered Water Within a Protein Hydrophobic Cavity by NMR by Ernst, James A., Clubb, Robert T., Zhou, Huan-Xiang, Gronenborn, Angela M., Clore, G. Marius

“…The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1β (hlL-1β) was investigated with…”
Get full text

Improved NMR spectra of a protein-DNA complex through rational mutagenesis and the application of a sensitivity optimized isotope-filtered NOESY experiment by Iwahara, J, Wojciak, J M, Clubb, R T

“…The NMR spectra of the complex between the DNA-binding domain of the Dead ringer protein (DRI-DBD, Gly262-Gly398) and its DNA binding site (DRI-DBD:DNA, 26…”
Get full text

A Comparative Genome Analysis Identifies Distinct Sorting Pathways in Gram-Positive Bacteria by COMFORT, David, CLUBB, Robert T

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Recent advances towards new anti-infective agents that inhibit cell surface protein anchoring in Staphylococcus aureus and other gram-positive pathogens by Suree, N, Jung, M E, Clubb, R T

“…Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor…”
Get more information

The Mu repressor-DNA complex contains an immobilized 'wing' within the minor groove by Clubb, Robert T, Wojciak, Jonathan M, Iwahara, Junji

“…We have determined the solution structure of the complex between the 'winged-helix' enhancer binding domain of the Mu repressor protein and its cognate DNA…”
Get full text

Finding the function buried in SAND by Clubb, Robert T, Wojciak, Jonathan M

Get full text

Structure of Sortase, The Transpeptidase That Anchors Proteins to the Cell Wall of Staphylococcus aureus by Ilangovan, Udayar, Ton-That, Hung, Iwahara, Junji, Schneewind, Olaf, Clubb, Robert T.

“…Surface proteins of Gram-positive bacteria play important roles during the pathogenesis of human infections and require sortase for anchoring to the cell-wall…”
Get full text

Mapping the binding surface of interleukin-8 complexed with an N-terminal fragment of the Type 1 human interleukin-8 receptor by Clubb, Robert T., Omichinski, James G., Clore, G.Marius, Gronenborn, Angela M.

“…Interleukin-8 and its receptors are key mediators of immune and inflammatory responses. Heteronuclear NMR spectroscopy has been utilized to map the binding…”
Get full text

Crystal Structure of the Excisionase–DNA Complex from Bacteriophage Lambda by Sam, My D., Cascio, Duilio, Johnson, Reid C., Clubb, Robert T.

“…The excisionase (Xis) protein from bacteriophage λ is the best characterized member of a large family of recombination directionality factors that control…”
Get full text

Sortase from Staphylococcus aureus Does Not Contain a Thiolate-Imidazolium Ion Pair in Its Active Site by Connolly, Kevin M., Smith, Brenton T., Pilpa, Rosemarie, Ilangovan, Udayar, Jung, Michael E., Clubb, Robert T.

“…Many surface proteins are anchored to the cell wall by the action of sortase enzymes, a recently discovered family of cysteine transpeptidases. As the surface…”
Get full text

The Wing of the Enhancer-Binding Domain of Mu Phage Transposase is Flexible and is Essential for Efficient Transposition by Clubb, Robert T., Mizuuchi, Michiyo, Huth, Jeffrey R., Omichinski, James G., Savilahti, Harri, Mizuuchi, Kiyoshi, Clore, G. Marius, Gronenborn, Angela M.

“…A tetramer of the Mu transposase (MuA) pairs the recombination sites, cleaves the donor DNA, and joins these ends to a target DNA by strand transfer…”
Get full text

The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA by Iwahara, Junji, Iwahara, Mizuho, Daughdrill, Gary W., Ford, Joseph, Clubb, Robert T.

“…The AT‐rich interaction domain (ARID) is a DNA‐binding module found in many eukaryotic transcription factors. Using NMR spectroscopy, we have determined the…”
Get full text

Arm-Site Binding by λ-Integrase: Solution Structure and Functional Characterization of Its Amino-Terminal Domain by Wojciak, Jonathan M., Sarkar, Dibyendu, Landy, Arthur, Clubb, Robert T.

“…The integrase protein (Int) from bacteriophage λ catalyzes the insertion and excision of the viral genome into and out of Escherichia coli. It is a member of…”
Get full text

Solution structure of the DNA binding domain from dead ringer, a sequence-specific AT-rich interaction domain (ARID) by Iwahara, J, Clubb, R.T

“…The Dead ringer protein from Drosophila melanogaster is a transcriptional regulatory protein required for early embryonic development. It is the founding…”
Get full text

Energetics of Sequence-Specific Protein−DNA Association:  Binding of Integrase Tn916 to Its Target DNA by Milev, Stoyan, Gorfe, Alemayehu A, Karshikoff, Andrey, Clubb, Robert T, Bosshard, Hans Rudolf, Jelesarov, Ilian

“…The DNA binding domain of the transposon Tn916 integrase (INT-DBD) binds to its DNA target site by positioning the face of a three-stranded antiparallel…”
Get full text

Three-Dimensional Solution Structure of Escherichia coli Periplasmic Cyclophilin by Clubb, Robert T, Ferguson, Stephen B, Walsh, Christopher T, Wagner, Gerhard

“…The solution structure of the periplasmic cyclophilin type cis-trans peptidyl-prolyl isomerase from Escherichia coli (167 residues, MW > 18.200) has been…”
Get full text

Identification of the λ Integrase Surface That Interacts with Xis Reveals a Residue That Is Also Critical for Int Dimer Formation by Warren, David, Sam, My D., Manley, Kate, Sarkar, Dibyendu, Lee, Sang Yeol, Abbani, Mohamad, Wojciak, Jonathan M., Clubb, Robert T., Landy, Arthur

“…Lambda integrase (Int) is a heterobivalent DNA-binding protein that together with the accessory DNA-bending proteins IHF, Fis, and Xis, forms the higher-order…”
Get full text

Xis Protein Binding to the Left Arm Stimulates Excision of Conjugative Transposon Tn916 by Connolly, Kevin M, Iwahara, Mizuho, Clubb, Robert T

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Energetics of Sequence-Specific Protein−DNA Association:  Conformational Stability of the DNA Binding Domain of Integrase Tn916 and Its Cognate DNA Duplex by Milev, Stoyan, Gorfe, Alemayehu A, Karshikoff, Andrey, Clubb, Robert T, Bosshard, Hans Rudolf, Jelesarov, Ilian

“…Sequence-specific DNA recognition by bacterial integrase Tn916 involves structural rearrangements of both the protein and the DNA duplex. Energetic…”
Get full text

NMR studies of structure and dynamics of isotope enriched proteins by Wagner, G, Thanabal, V, Stockman, B J, Peng, J W, Nirmala, N R, Hyberts, S G, Goldberg, M S, Detlefsen, D J, Clubb, R T, Adler, M

“…Structural studies of globular proteins by nmr can be enhanced by the use of isotope enrichment. We have been working with proteins enriched with 15N, and with…”
Get more information