Search Results - "Clubb, R"
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Why and how should we use environmental enrichment to tackle stereotypic behaviour?
Published in Applied animal behaviour science (01-02-2007)“…This paper summarises recent findings on the causation of stereotypic behaviours and other abnormal repetitive behaviours (ARBs) in captive animals: primarily…”
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Recent advances towards new anti-infective agents that inhibit cell surface protein anchoring in Staphylococcus aureus and other gram-positive pathogens
Published in Mini reviews in medicinal chemistry (01-10-2007)“…Sortase enzymes are attractive targets for the development of new anti-infective agents against Gram-positive pathogens because they covalently anchor…”
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A Comparative Genome Analysis Identifies Distinct Sorting Pathways in Gram-Positive Bacteria
Published in Infection and Immunity (01-05-2004)“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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A Suicide Prevention Digital Technology for Individuals Experiencing an Acute Suicide Crisis in Emergency Departments: Naturalistic Observational Study of Real-World Acceptability, Feasibility, and Safety
Published in JMIR formative research (16-09-2024)“…Emergency departments (EDs) are the front line in providing suicide care. Expert consensus recommends the delivery of several suicide prevention evidence-based…”
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Structure of Sortase, The Transpeptidase That Anchors Proteins to the Cell Wall of Staphylococcus aureus
Published in Proceedings of the National Academy of Sciences - PNAS (22-05-2001)“…Surface proteins of Gram-positive bacteria play important roles during the pathogenesis of human infections and require sortase for anchoring to the cell-wall…”
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Demonstration of Positionally Disordered Water Within a Protein Hydrophobic Cavity by NMR
Published in Science (American Association for the Advancement of Science) (24-03-1995)“…The presence and location of water of hydration (that is, bound water) in the solution structure of human interleukin-1β (hlL-1β) was investigated with…”
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Improved NMR spectra of a protein-DNA complex through rational mutagenesis and the application of a sensitivity optimized isotope-filtered NOESY experiment
Published in Journal of biomolecular NMR (01-03-2001)“…The NMR spectra of the complex between the DNA-binding domain of the Dead ringer protein (DRI-DBD, Gly262-Gly398) and its DNA binding site (DRI-DBD:DNA, 26…”
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G218(P) A new sepsis tool: improving the management of children with suspected sepsis in our emergency department, with an unexpected bonus
Published in Archives of disease in childhood (01-10-2020)“…AimSepsis is a leading cause of morbidity and mortality in children. Early recognition and appropriate management can save lives.With on-going staff cover…”
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G183(P) Clinical management of acute pain in paediatric sickle cell disease (SCD) following the nice guidance (CG143)
Published in Archives of disease in childhood (01-10-2020)“…AimsTo assess if children with SCD presenting to our District General Hospital with an acute painful episode are managed in line with NICE guidance.To compare…”
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The Mu repressor-DNA complex contains an immobilized 'wing' within the minor groove
Published in Nature structural biology (01-01-2001)“…We have determined the solution structure of the complex between the 'winged-helix' enhancer binding domain of the Mu repressor protein and its cognate DNA…”
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Crystal Structure of the Excisionase–DNA Complex from Bacteriophage Lambda
Published in Journal of molecular biology (23-04-2004)“…The excisionase (Xis) protein from bacteriophage λ is the best characterized member of a large family of recombination directionality factors that control…”
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Sortase from Staphylococcus aureus Does Not Contain a Thiolate-Imidazolium Ion Pair in Its Active Site
Published in The Journal of biological chemistry (05-09-2003)“…Many surface proteins are anchored to the cell wall by the action of sortase enzymes, a recently discovered family of cysteine transpeptidases. As the surface…”
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13
Finding the function buried in SAND
Published in Nature structural biology (01-07-2001)Get full text
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14
Mapping the binding surface of interleukin-8 complexed with an N-terminal fragment of the Type 1 human interleukin-8 receptor
Published in FEBS letters (24-01-1994)“…Interleukin-8 and its receptors are key mediators of immune and inflammatory responses. Heteronuclear NMR spectroscopy has been utilized to map the binding…”
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The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA
Published in The EMBO journal (01-03-2002)“…The AT‐rich interaction domain (ARID) is a DNA‐binding module found in many eukaryotic transcription factors. Using NMR spectroscopy, we have determined the…”
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Arm-Site Binding by λ-Integrase: Solution Structure and Functional Characterization of Its Amino-Terminal Domain
Published in Proceedings of the National Academy of Sciences - PNAS (19-03-2002)“…The integrase protein (Int) from bacteriophage λ catalyzes the insertion and excision of the viral genome into and out of Escherichia coli. It is a member of…”
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G179(P) Emergency management of acute painful crisis in paediatric sickle cell patients; investigating analgesic treatment delays at a district general hospital
Published in Archives of disease in childhood (01-10-2020)“…AimsTo evaluate the initial management of sickle cell (SC) patients presenting to our Paediatric Assessment Unit (PAU) with vaso-occlusive crisis (VOC), with…”
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Solution structure of the DNA binding domain from dead ringer, a sequence-specific AT-rich interaction domain (ARID)
Published in The EMBO journal (01-11-1999)“…The Dead ringer protein from Drosophila melanogaster is a transcriptional regulatory protein required for early embryonic development. It is the founding…”
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Captivity effects on wide-ranging carnivores
Published in Nature (London) (02-10-2003)“…Certain species of wildlife are known to thrive in captivity, while others seem to languish into decay fairly rapidly under captive conditions. A study was…”
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Three-Dimensional Solution Structure of Escherichia coli Periplasmic Cyclophilin
Published in Biochemistry (Easton) (15-03-1994)“…The solution structure of the periplasmic cyclophilin type cis-trans peptidyl-prolyl isomerase from Escherichia coli (167 residues, MW > 18.200) has been…”
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