Search Results - "Cloyd, J C"

The Role of Academic Institutions in the Development of Drugs for Rare and Neglected Diseases by Coles, L D, Cloyd, J C

“…There are approximately 7,000 rare disorders, many of which are life‐threatening. Diagnosis is often problematic, and therapies are few. Before the passage of…”
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Pharmacological and clinical aspects of antiepileptic drug use in the elderly by Perucca, E., Berlowitz, D., Birnbaum, A., Cloyd, J.C., Garrard, J., Hanlon, J.T., Levy, R.H., Pugh, M.J.

“…In this article, epidemiological and clinical aspects related to the use of antiepileptic drugs (AEDs) in the elderly are highlighted. Studies have shown that…”
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Steady‐State Carbamazepine Pharmacokinetics Following Oral and Stable‐Labeled Intravenous Administration in Epilepsy Patients: Effects of Race and Sex by Marino, S E, Birnbaum, A K, Leppik, I E, Conway, J M, Musib, L C, Brundage, R C, Ramsay, R E, Pennell, P B, White, J R, Gross, C R, Rarick, J O, Mishra, U, Cloyd, J C

“…Carbamazepine is a widely prescribed antiepileptic drug. Owing to the lack of an intravenous formulation, its absolute bioavailability, absolute clearance, and…”
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Pharmacokinetics and tolerability of intranasal diazepam and midazolam in healthy adult volunteers by Ivaturi, V. D., Riss, J. R., Kriel, R. L., Cloyd, J. C.

“…Objective –  The purpose of this pilot study was to determine the pharmacokinetics and tolerability of an investigational diazepam (DZP) formulation and a…”
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Lower phenytoin serum levels in persons switched from brand to generic phenytoin by BURKHARDT, R. T, LEPPIK, I. E, BLESI, K, SCOTT, S, GAPANY, S. R, CLOYD, J. C

“…After generic phenytoin (PHT) was marketed, the authors identified eight adult patients (ages 34 to 49) whose seizures increased enough to require intervention…”
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Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy by AHN, J. E, CLOYD, J. C, LEPPIK, I. E, BRUNDAGE, R. C, MARINO, S. E, CONWAY, J. M, RAMSAY, R. E, WHITE, J. R, MUSIB, L. C, RARICK, J. O, BIRNBAUM, A. K

“…Phenytoin (PHT) is widely used to treat epilepsy in elderly patients, but information on its pharmacokinetics in this population is limited. The purpose of…”
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A Comparison of Rectal Diazepam Gel and Placebo for Acute Repetitive Seizures by Dreifuss, Fritz E, Rosman, N. Paul, Cloyd, James C, Pellock, John M, Kuzniecky, Ruben I, Lo, Warren D, Matsuo, Fumisuke, Sharp, Gregory B, Conry, Joan A, Bergen, Donna C, Bell, Walter E

“…Epilepsy is among the most common neurologic disorders, affecting approximately two million people in the United States. 1 Epileptic-seizure recurrences…”
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Safety and tolerance of rapidly infused Depacon®: A randomized trial in subjects with epilepsy by Ramsay, R.E, Cantrell, D, Collins, S.D, Walch, J.K, Naritoku, D.K, Cloyd, J.C, Sommerville, K

“…Background: Valproate sodium injection (Depacon®) is an intravenous form of valproate for use in absence and complex partial seizures when circumstances…”
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Effect of food on absorption of Dilantin Kapseals and Mylan extended phenytoin sodium capsules by Wilder, B J, Leppik, I, Hietpas, T J, Cloyd, J C, Randinitis, E J, Cook, J

“…Because of phenytoin's narrow therapeutic index and nonlinear pharmacokinetics, food-induced alterations in absorption may markedly influence drug…”
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Antiepileptic Drug Pharmacokinetics and Interactions: Impact on Treatment of Epilepsy by Cloyd, James C., Remmel, Rory P.

“…An understanding of epilepsy therapy's pharmacokinetic and drug interaction principles—combined with knowledge of antiepileptic drug (AED) clinical…”
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A Single‐Blind, Crossover Comparison of the Pharmacokinetics and Cognitive Effects of a New Diazepam Rectal Gel with Intravenous Diazepam by Cloyd, James C., Lalonde, Richard L., Beniak, Thomas E., Novack, Gary D.

“…Purpose: The objective of this study was to compare the pharmacokinetics and cognitive effects of a new diazepam (DZP) rectal gel (Diastat®) with intravenously…”
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Antiepileptic Drug Use in Nursing Home Residents: Effect of Age, Gender, and Comedication on Patterns of Use by Lackner, Thomas E., Cloyd, James C., Thomas, Lucy W., Leppik, Ilo E.

“…Purpose: Examine antiepileptic drug (AED) use in nursing homes by age, gender, and use of comedication that can interact with AEDs. Methods: Two…”
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Intramuscular, intravenous and oral levetiracetam in dogs: safety and pharmacokinetics by PATTERSON, E.E, GOEL, V, CLOYD, J.C, O'BRIEN, T.D, FISHER, J.E, DUNN, A.W, LEPPIK, I.E

“…Intravenous (IV) levetiracetam (LEV) is available for humans for bridge therapy when the oral route is unavailable. We investigated the safety and…”
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Failure of Absorption of Gabapentin After Rectal Administration by Kriel, Robert L., Birnbaum, Angela K., Cloyd, James C., Ricker, Beverly J., Saete, Carolyn Jones, Caruso, Kimberly J.

“…Purpose: We wished to determine the extent of absorption of gabapentin (GBP) after rectal administration to children on maintenance therapy. Methods: Two…”
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Home use of rectal diazepam for cluster and prolonged seizures: efficacy, adverse reactions, quality of life, and cost analysis by Kriel, R L, Cloyd, J C, Hadsall, R S, Carlson, A M, Floren, K L, Jones-Saete, C M

“…From 1982 through 1987, 128 families, who were instructed in the use of rectally administered diazepam (R-DZP) for the treatment of severe epileptic seizures,…”
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Mannitol pharmacokinetics and serum osmolality in dogs and humans by Cloyd, J C, Snyder, B D, Cleeremans, B, Bundlie, S R, Blomquist, C H, Lakatua, D J

“…The relationship between mannitol pharmacokinetics and changes in serum osmolality were studied in dogs and humans. Four human subjects each received between…”
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Comparison of sprinkle versus syrup formulations of valproate for bioavailability, tolerance, and preference by Cloyd, J C, Kriel, R L, Jones-Saete, C M, Ong, B Y, Jancik, J T, Remmel, R P

“…We compared a new coated-particle formulation of valproate (Depakote Sprinkle) capsules with valproic acid (Depakene) syrup for bioavailability, side effects,…”
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Central issues relevant to clinical pharmaceutical scientist training programs by Blouin, R A, Cloyd, J C, Ludden, T M, Kroboth, P D

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External leakage from feeding gastrostomies in patients receiving valproate sprinkle by Jones-Saete, C, Kriel, R L, Cloyd, J C

“…We reviewed the incidence of external leakage from feeding gastrostomies in 8 patients who received valproate sprinkle (VPA-S). We also identified a control…”
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Poly(tertiary phosphines and arsines). XI. Phosphorus-31 nuclear magnetic resonance studies on some metal complexes of poly(tertiary phosphines) by King, R. B, Cloyd, J. C

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