Search Results - "Clowes, Alexander W."

M2 Macrophage Polarization Mediates Anti-inflammatory Effects of Endothelial Nitric Oxide Signaling by Lee, Woo Je, Tateya, Sanshiro, Cheng, Andrew M, Rizzo-DeLeon, Norma, Wang, Nicholas F, Handa, Priya, Wilson, Carole L, Clowes, Alexander W, Sweet, Ian R, Bomsztyk, Karol, Schwartz, Michael W, Kim, Francis

“…Endothelial nitric oxide (NO) signaling plays a physiological role in limiting obesity-associated insulin resistance and inflammation. This study was…”
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Technical factors affecting autogenous vein graft failure: Observations from a large multicenter trial by Schanzer, Andres, MD, Hevelone, Nathanael, MPH, Owens, Christopher D., MD, Belkin, Michael, MD, Bandyk, Dennis F., MD, Clowes, Alexander W., MD, Moneta, Gregory L., MD, Conte, Michael S., MD

“…Objective The influence of operator-dependent variables on the outcomes of lower extremity bypass (LEB) surgery have primarily been reported in…”
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Results of PREVENT III: A multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery by Conte, Michael S., Bandyk, Dennis F., Clowes, Alexander W., Moneta, Gregory L., Seely, Lynn, Lorenz, Todd J., Namini, Hamid, Hamdan, Allen D., Roddy, Sean P., Belkin, Michael, Berceli, Scott A., DeMasi, Richard J., Samson, Russell H., Berman, Scott S.

“…The PREVENT III study was a prospective, randomized, double-blinded, multicenter phase III trial of a novel molecular therapy (edifoligide; E2F decoy) for the…”
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Reduced Vascular Nitric Oxide–cGMP Signaling Contributes to Adipose Tissue Inflammation During High-Fat Feeding by Handa, Priya, Tateya, Sanshiro, Rizzo, Norma O, Cheng, Andrew M, Morgan-Stevenson, Vicki, Han, Chang-Yeop, Clowes, Alexander W, Daum, Guenter, OʼBrien, Kevin D, Schwartz, Michael W, Chait, Alan, Kim, Francis

“…OBJECTIVE—Obesity is characterized by chronic inflammation of adipose tissue, which contributes to insulin resistance and diabetes. Although nitric oxide (NO)…”
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Scavenger receptor class A member 5 ( SCARA5 ) and suprabasin ( SBSN ) are hub genes of coexpression network modules associated with peripheral vein graft patency by Kenagy, Richard D., PhD, Civelek, Mete, PhD, Kikuchi, Shinsuke, MD, Chen, Lihua, PhD, Grieff, Anthony, BA, Sobel, Michael, MD, Lusis, Aldons J., PhD, Clowes, Alexander W., MD

“…Objective Approximately 30% of autogenous vein grafts develop luminal narrowing and fail because of intimal hyperplasia or negative remodeling. We previously…”
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Female gender and oral anticoagulants are associated with wound complications in lower extremity vein bypass: An analysis of 1404 operations for critical limb ischemia by Nguyen, Louis L., MD, MBA, MPH, Brahmanandam, Soma, MD, Bandyk, Dennis F., MD, Belkin, Michael, MD, Clowes, Alexander W., MD, Moneta, Gregory L., MD, Conte, Michael S., MD

“…Background Infrainguinal bypass (IB) surgery is an effective means of improving arterial circulation to the lower extremity for patients with critical limb…”
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Vasospasm as a cause for claudication in athletes with external iliac artery endofibrosis by Shalhub, Sherene, MD, MPH, Zierler, R. Eugene, MD, Smith, Watson, BA, RDMS, RVT, Olmsted, Kari, BS, RVT, Clowes, Alexander W., MD

“…Background Exercise-induced external iliac artery endofibrosis (EIAE) is rare and has been described primarily in endurance male cyclists. Clinically, it…”
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Risk factors, medical therapies and perioperative events in limb salvage surgery: Observations from the PREVENT III multicenter trial by Conte, Michael S., Bandyk, Dennis F., Clowes, Alexander W., Moneta, Gregory L., Namini, Hamid, Seely, Lynn

“…Patients who require infrainguinal revascularization for critical limb ischemia (CLI) are at elevated risk for cardiovascular events. The PREVENT III study was…”
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Vasodilator-stimulated phosphoprotein protects against vascular inflammation and insulin resistance by Cheng, Andrew M, Rizzo-DeLeon, Norma, Wilson, Carole L, Lee, Woo Je, Tateya, Sanshiro, Clowes, Alexander W, Schwartz, Michael W, Kim, Francis

“…Among the pleotropic effects of endothelial nitric oxide (NO) is protection against vascular inflammation during high-fat diet (HFD) feeding. The current work…”
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Surgical and endovascular revision of infrainguinal vein bypass grafts: Analysis of midterm outcomes from the PREVENT III trial by Berceli, Scott A., MD, PhD, Hevelone, Nathanael D., MPH, Lipsitz, Stuart R., PhD, Bandyk, Dennis F., MD, Clowes, Alexander W., MD, Moneta, Gregory L., MD, Conte, Michael S., MD

“…Objective Data supporting the utility of percutaneous treatment to maintain vein graft patency have been limited to a collection of single-institution,…”
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Low levels of a natural IgM antibody are associated with vein graft stenosis and failure by Sobel, Michael, MD, Moreno, Katherine I., MD, Yagi, Mayumi, PhD, Kohler, Ted R., MD, Tang, Gale L., MD, Clowes, Alexander W., MD, Zhou, Xiao-Hua A., PhD, Eugenio, Evercita, MS

“…Background All humans have natural, protective antibodies directed against phosphorylcholine (PC) epitopes, a common inflammatory danger signal appearing at…”
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Platelet-Derived Growth Factor-BB–Induced Human Smooth Muscle Cell Proliferation Depends on Basic FGF Release and FGFR-1 Activation by Millette, Esther, Rauch, Bernhard H, Defawe, Olivier, Kenagy, Richard D, Daum, Guenter, Clowes, Alexander W

“…We have shown that the G protein–coupled receptor (GPCR) agonists, thrombin and Factor Xa, stimulate smooth muscle cell (SMC) proliferation through…”
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A link between smooth muscle cell death and extracellular matrix degradation during vascular atrophy by Kenagy, Richard D., PhD, Min, Seung-Kee, MD, PhD, Mulvihill, Eileen, PhD, Clowes, Alexander W., MD

“…Objective High blood flow induces neointimal atrophy in polytetrafluoroethylene (PTFE) aortoiliac grafts and a tight external PTFE wrap of the iliac artery…”
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Cell Death-associated ADAMTS4 and Versican Degradation in Vascular Tissue by Kenagy, Richard D, Min, Seung-Kee, Clowes, Alexander W, Sandy, John D

“…High blood flow through baboon polytetrafluorethylene aorto-iliac grafts increases neointimal vascular smooth muscle cell (SMC) death, neointimal atrophy, and…”
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Inhibition of Versican Synthesis by Antisense Alters Smooth Muscle Cell Phenotype and Induces Elastic Fiber Formation In Vitro and in Neointima After Vessel Injury by Huang, Robert, Merrilees, Mervyn J, Braun, Kathleen, Beaumont, Brent, Lemire, Joan, Clowes, Alexander W, Hinek, Aleksander, Wight, Thomas N

“…The proteoglycan versican is implicated in several atherogenic events, including stimulation of vascular smooth muscle cell (VSMC) growth and migration,…”
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Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors by Braun, Kathleen R, DeWispelaere, Allison M, Bressler, Steven L, Fukai, Nozomi, Kenagy, Richard D, Chen, Lihua, Clowes, Alexander W, Kinsella, Michael G

“…Syndecans are receptors for soluble ligands, including heparin-binding growth factors, and matrix proteins. However, intracellular targets of syndecan-1…”
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Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis by Kenagy, Richard D., PhD, Fukai, Nozomi, MD, PhD, Min, Seung-Kee, MD, Jalikis, Florencia, MD, Kohler, Ted R., MD, Clowes, Alexander W., MD

“…Objective About a quarter of peripheral vein grafts fail due in part to intimal hyperplasia. The proliferative capacity and response to growth inhibitors of…”
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Syndecan-4 Is Required for Thrombin-induced Migration and Proliferation in Human Vascular Smooth Muscle Cells by Rauch, Bernhard H., Millette, Esther, Kenagy, Richard D., Daum, Guenter, Fischer, Jens W., Clowes, Alexander W.

“…Thrombin is a mitogen and chemoattractant for vascular smooth muscle cells (SMCs) and may contribute to vascular lesion formation. We have previously shown…”
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Heparin Blockade of Thrombin-Induced Smooth Muscle Cell Migration Involves Inhibition of Epidermal Growth Factor (EGF) Receptor Transactivation by Heparin-Binding EGF-Like Growth Factor by Kalmes, Andreas, Vesti, Beatrice R, Daum, Günter, Abraham, Judith A, Clowes, Alexander W

“…Agonists of G protein–coupled receptors, such as thrombin, act in part by transactivating the epidermal growth factor (EGF) receptor (EGFR). Although at first…”
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Thrombin- and Factor Xa–Induced DNA Synthesis Is Mediated by Transactivation of Fibroblast Growth Factor Receptor-1 in Human Vascular Smooth Muscle Cells by Rauch, Bernhard H, Millette, Esther, Kenagy, Richard D, Daum, Guenter, Clowes, Alexander W

“…ABSTRACT—Thrombin and factor Xa (FXa) are agonists for G protein–coupled receptors (GPRCs) and may contribute to vascular lesion formation by stimulating…”
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