Search Results - "Clough, Courtnee A."

Coordinated missplicing of TMEM14C and ABCB7 causes ring sideroblast formation in SF3B1-mutant myelodysplastic syndrome by Clough, Courtnee A., Pangallo, Joseph, Sarchi, Martina, Ilagan, Janine O., North, Khrystyna, Bergantinos, Rochelle, Stolla, Massiel C., Naru, Jasmine, Nugent, Patrick, Kim, Eunhee, Stirewalt, Derek L., Subramaniam, Arvind R., Abdel-Wahab, Omar, Abkowitz, Janis L., Bradley, Robert K., Doulatov, Sergei

“…SF3B1 splicing factor mutations are near-universally found in myelodysplastic syndromes (MDS) with ring sideroblasts (RS), a clonal hematopoietic disorder…”
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Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes by Hsu, Jasper, Reilly, Andreea, Hayes, Brian J., Clough, Courtnee A., Konnick, Eric Q., Torok-Storb, Beverly, Gulsuner, Suleyman, Wu, David, Becker, Pamela S., Keel, Siobán B., Abkowitz, Janis L., Doulatov, Sergei

“…Myeloid neoplasms, including myelodysplastic syndromes (MDS), are genetically heterogeneous disorders driven by clonal acquisition of somatic mutations in…”
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pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences by Grier, Alexandra E, Burleigh, Stephen, Sahni, Jaya, Clough, Courtnee A, Cardot, Victoire, Choe, Dongwook C, Krutein, Michelle C, Rawlings, David J, Jensen, Michael C, Scharenberg, Andrew M, Jacoby, Kyle

“…Increasing demand for large-scale synthesis of in vitro transcribed (IVT) mRNA is being driven by the increasing use of mRNA for transient gene expression in…”
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ATG4A regulates human erythroid maturation and mitochondrial clearance by Stolla, Massiel Chavez, Reilly, Andreea, Bergantinos, Rochelle, Stewart, Sintra, Thom, Neele, Clough, Courtnee A., Wellington, Rachel C., Stolitenko, Raisa, Abkowitz, Janis L., Doulatov, Sergei

“…Autophagy is a self-degradation pathway that is essential for erythropoiesis. During erythroid differentiation, autophagy facilitates the degradation of…”
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Clonal Trajectories and Therapeutic Targeting of High-Risk SF3B1-Mutant Myelodysplastic Syndromes by Sarchi, Martina, Clough, Courtnee A, Gallì, Anna, Todisco, Gabriele, Creamer, J. Philip, Malcovati, Luca, Doulatov, Sergei

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Modeling Clonal Progression in SF3B1-Mutant Myelodysplastic Syndrome by Sarchi, Martina, Gallì, Anna, Clough, Courtnee A, Todisco, Gabriele, Creamer, J. Philip, Malcovati, Luca, Doulatov, Sergei

“…SF3B1-mutant myelodysplastic syndrome (MDS) has recently been proposed as a distinct disorder characterized by ring sideroblasts, ineffective erythropoiesis…”
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Mitotic Dysregulation Sensitizes Malignant Stem Cells to CHK1 Inhibition in SF3B1-Mutant Myeloid Neoplasms by Sarchi, Martina, Clough, Courtnee A., Crosse, Edie I., Kim, Jason, Baquero Galvis, Laura D., Gallì, Anna, Creamer, J. Philip, Stewart, Sintra, Pozzi, Sara, Molteni, Elisabetta, Elena, Chiara, Bradley, Robert K., Malcovati, Luca, Doulatov, Sergei

“…Myelodysplastic syndromes (MDS) arise from the acquisition of driver mutations in hematopoietic stem cells (HSCs). Splicing factor SF3B1 mutations are…”
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Dissecting the Role of Aberrant Splicing in Mutant-SF3B1 Myelodysplastic Syndromes by Clough, Courtnee A

“…Mutations in RNA splicing factors are the most recurrent genetic aberrations found in myeloid malignancies, such as myelodysplastic syndromes (MDS). These…”
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