Search Results - "Clothier, R.H."

The relative embryotoxicity of 1,3-dichloro-2-propanol on primary chick embryonic cells by L’Huillier, N, Pratten, M.K, Clothier, R.H

“…1,3-Dichloro-2-propanol (1,3-DCP) is a chlorinated compound used in the fabrication of industrial products such as hard resins, celluloid or paints. It has…”
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An evaluation of three in vitro cytotoxicity assays by Riddell, R J, Clothier, R H, Balls, M

“…A number of methods for determining the general toxic effects of test chemicals on cells in culture are now at the validation stage. Three such methods based…”
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Expression of a Fas-like proapoptotic molecule on the lymphocytes of Xenopus laevis by Mangurian, C., Johnson, R.O., McMahan, R., Clothier, R.H., Ruben, L.N.

“…Ligation of the externally expressed Fas (APO 1/CD95) molecule will initiate programmed cell death (apoptosis), in many mammalian developing and adult cells…”
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Effects of THz Exposure on Human Primary Keratinocyte Differentiation and Viability by Clothier, R H, Bourne, N

“…Primary human keratinocytes can be driven,in vitro, to differentiate, viaactivation of transglutaminases, by raisingthe culture medium calcium…”
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Evaluation of a proposed in vitro test strategy using neuronal and non-neuronal cell systems for detecting neurotoxicity by Gartlon, J., Kinsner, A., Bal-Price, A., Coecke, S., Clothier, R.H.

“…The European Commission White Paper, “Strategy for a future chemicals policy” (EC, 2001) is estimated to require the testing of approximately 30,000 ‘existing’…”
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164 Evaluation of the effects of chronic subcytotoxic surfactant exposure to a human corneal cell line by Wilkinson, P.J., Clothier, R.H.

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Assessment of primary eye and skin irritants by in vitro cytotoxicity and phototoxicity models: an in vitro approach of new arginine-based surfactant-induced irritation by Benavides, T, Mitjans, M, Martı́nez, V, Clapés, P, Infante, M.R, Clothier, R.H, Vinardell, M.P

“…Extensive efforts have been made, recently, to find surfactants with lower irritation potential than those presently commercially available, for use in…”
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evaluation of the effects of photoactivation of bithionol, amiodarone and chlorpromazine on human keratinocytes in vitro by Reid, L, Khammo, N, Clothier, R.H

“…Human skin is a continual target for chemical toxicity, due to its constant exposure to xenobiotics. The skin possesses a number of protective antioxidant…”
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review of in vitro modelling approaches to the identification and modulation of squamous metaplasia in the human tracheobronchial epithelium by Gray, A.C, McLeod, J.D, Clothier, R.H

“…Squamous metaplasia in the tracheobronchial epithelium (TBE) involves the replacement of the normal pseudostratified mucociliary epithelium with a stratified…”
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Cancer resistance in amphibians by Ruben, L.N, Clothier, R.H, Balls, M

“…While spontaneous tumours may occasionally develop in inbred and isogenic strains of Xenopus laevis, the South African clawed toad, they are extremely rare in…”
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Development of an innervated model of human skin by Khammo, N, Ogilvie, J, Clothier, R.H

“…Neuronal cell responses and interactions with the epithelial and fibroblastic cells of the skin are a key factor in the production in vivo of the…”
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Hydrogen peroxide induced stress in human keratinocytes and its effect on bithionol toxicity by Reid, L, Clothier, R.H, Khammo, N

“…Exposure to hydrogen peroxide causes oxidative stress in keratinocytes. Previous work has shown that the antiparasitic drug bithionol has an EC 50 of 0.7 μg/ml…”
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The use of an in vitro submerged keratinocyte model to predict induction of squamous metaplasia by Gray, A.C, Clothier, R.H

“…An in vitro submerged keratinocyte model of squamous metaplasia (SQ) in epithelia is being developed to assess the risk associated with exposure to certain…”
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Human keratinocyte cultures in an in vitro approach for the assessment of surfactant-induced irritation by Ward, R.K., Hubbard, A.W., Sulley, H., Garle, M.J., Clothier, R.H.

“…A specific, mechanistic, in vitro approach for the assessment of human skin irritation potential is outlined for the evaluation of surfactants and the results…”
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An in vitro approach to the evaluation of repeat exposure in the prediction of toxicity by Clothier, R.H., Beed, M., Samson, R., Ward, R.

“…A strategy for the examination of repeat chronic exposure employed chemicals in the MEIC scheme. Repeat exposure to a non-cytotoxic concentration of certain…”
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Human keratinocyte cultures as models of cutaneous esterase activity by Barker, C.L., Clothier, R.H.

“…A reproducible, quantifiable assay has been developed for the measurement of esterase activity in human keratinocyte cultures, using the model substrate…”
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Histamine-induced Changes in the Actin Cytoskeleton of the Human Microvascular Endothelial Cell line HMEC-1 by Budworth, R.A., Anderson, M., Clothier, R.H., Leach, L.

“…Increased permeability of the microvascular endothelium is a component of the inflammatory response. Inflammatory mediators such as histamine contribute to…”
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Apoptosis and the cell cycle in Xenopus laevis: PHA and PMA exposure of splenocytes by McMahan, R, Johnson, R.O, Ruben, L.N, Clothier, R.H

“…T cell receptor (TCR) ligation and protein kinase C (PKC) activation stimulate proliferation and modulate apoptosis in both mammalian and amphibian…”
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Fluorescein Cadaverine Incorporation as a Novel Technique for the Characterization of Terminal Differentiation in Keratinocytes by Gray, A.C., Garle, M.J., Clothier, R.H.

“…A novel technique for detecting transglutaminase activity and the production of cornified envelopes in keratinocytes has been devised. This was based on the…”
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Evaluation of tissue culture insert membrane compatibility in the fluorescein leakage assay by Ward, R.K., Mungall, S., Carter, J., Clothier, R.H.

“…The Fluorescein Leakage (FL) test, a short-term in vitro assay measuring damage on exposure to eye irritants to a transepithelial barrier permeability system,…”
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