Search Results - "Closkey, Thomas W. Mc"

Recommendations for the validation of flow cytometric testing during drug development: I instrumentation by Green, Cherie L., Brown, Lynette, Stewart, Jennifer J., Xu, Yuanxin, Litwin, Virginia, Mc Closkey, Thomas W.

“…Flow cytometry is a powerful and flexible analytical tool used during all stages of drug development. While substantial effort is invested in development and…”
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Recommendations for the development and validation of flow cytometry-based receptor occupancy assays by Green, Cherie L., Stewart, Jennifer J., Högerkorp, Carl-Magnus, Lackey, Alan, Jones, Nicholas, Liang, Meina, Xu, Yuanxin, Ferbas, John, Moulard, Maxime, Czechowska, Kamila, Mc Closkey, Thomas W., van der Strate, Barry W.A., Wilkins, Danice E.C., Lanham, David, Wyant, Timothy, Litwin, Virginia

“…Receptor occupancy measurements demonstrate the binding of a biotherapeutic agent to its extra‐cellular target and represent an integral component of the…”
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Validation of a flow cytometry-based assay to assess C5aR receptor occupancy on neutrophils and monocytes for use in drug development by Quadrini, Karen J., Hegelund, Anne Charlotte, Cortes, Kasia E., Xue, Chengsen, Kennelly, Susan M., Ji, Hong, Högerkorp, Carl-Magnus, Mc Closkey, Thomas W.

“…The C5a/C5a receptor (C5aR) pathway, a key component in the proinflammatory immune response, is an attractive therapeutic target since its dysregulation is…”
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Abstract 512: Tetramer and pentamer assays for antigen-specific lymphocytes: Implementation in clinical trials by Xue, Chengsen, Zhong, Weiguo, Cho, Yeji, Cuomo, Joanne, Swenson, Christina D., Closkey, Thomas W. Mc

“…Abstract The success of inhibiting PD1 on T cells for cancer immunotherapy initiated strong interest in studying therapeutic antibodies to alter the adaptive…”
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Abstract 5588: Uneven distribution of CTCs in magnetic fields following binding with iron nanoparticles by Xue, Chengsen, Swenson, Christina D., Closkey, Thomas W. Mc

“…Abstract Circulating tumor cell (CTC) detection and characterization have recently become an integral part of precision medicine. Several large, multicenter…”
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Abstract 1171: Estimating sensitivity of exploratory cellular biomarkers in oncology clinical trials by Xue, Chengsen, Swenson, Christina D., Mc Closkey, Thomas W.

“…Abstract Background: In the prolonged and complex process of assessing immunotherapeutic oncology drug candidates, flow cytometry plays an essential role. In…”
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Abstract 5593: Identification and characterization of an unusual monocyte subpopulation by Xue, Chengsen, Cuomo, Joanne, Rows, Lucie-Emily, Chen, Kai, Swenson, Chrinstina D., Mc Closkey, Thomas W.

“…Abstract Personalized immunotherapy for cancer has become an effective treatment choice in certain oncology indications. To successfully develop such…”
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Abstract 1608: CTC categorization: Subpopulations of CTCs and their potential clinical significance by Xue, Chengsen, Mc Closkey, Thomas W.

“…Abstract Circulating tumor cells (CTCs) were previously rare events difficult to identify. In clinical practice, CTC enumeration has now been recognized for…”
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Abstract 2605: Improving data quality in oncology immunotherapy clinical research by big data analytics and data visualization by Xue, Chengsen, Cuomo, Joanne, Meyers, Walter, Closkey, Thomas W. Mc

“…Abstract Flow cytometric assessment of cellular and intracellular biomarkers facilitates the development of new classes of cancer immunotherapy therapeutics…”
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Abstract 5115: Enhancing data quality for clinical studies of investigational cancer immunotherapy drug candidates by a new data analytics tool by Xue, Chengsen, Cuomo, Joanne, Baptiste, Melissa L., Chen, Kai, Kurkowski, Danielle L., Closkey, Thomas W. Mc

“…Abstract Cancer immunotherapy is rapidly becoming a treatment of choice in fighting deadly cancers, especially late stage or metastatic cancers. Humanized…”
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Lipopolysaccharide treatment of rats alters antigen expression and oxidative metabolism in hepatic macrophages and endothelial cells by McCloskey, T W, Todaro, J A, Laskin, D L

“…Endothelial cells and macrophages are located within the hepatic sinusoids. These two cell types play an important role in the clearance of bacterially derived…”
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Abstract 4821: Circulating tumor cells: A key deliverable in oncology clinical trials by Xue, Chengsen, Cortes, Kasia E., Hura, Dorina, Baptiste, Melissa L., Renato, Paradiso, Cuomo, Joanne, Closkey, Thomas W. Mc

“…Abstract Circulating tumor cell (CTC) enumeration is a new pharmacodynamic biomarker developed from an emerging rare event technology showing prognostic…”
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Mechanism of apoptosis in peripheral blood mononuclear cells of HIV-infected patients by Oyaizu, N, McCloskey, T W, Than, S, Hu, R, Pahwa, S

“…Lymphocytes from patients with HIV-infection have been shown to undergo accelerated spontaneous apoptosis. Binding of CD4 molecules by HIV envelope protein…”
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Flow cytometry for evaluation and investigation of human immunodeficiency virus infection by Mc Closkey, Thomas W.

“…The technology of flow cytometry plays a major role in human immunodeficiency virus (HIV), in both patient monitoring and in research that has elucidated…”
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Recommendations for the validation of flow cytometric testing during drug development: I instrumentation: Flow Cytometry-based Biomarkers in Translational Medicine and Drug Development by GREEN, Cherie L, BROWN, Lynette, STEWART, Jennifer J, YUANXIN XU, LITWIN, Virginia, MC CLOSKEY, Thomas W

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Inhibition of CD4 Cross-Linking-Induced Lymphocytes Apoptosis by Vesnarinone as a Novel Immunomodulating Agent: Vesnarinone Inhibits Fas Expression and Apoptosis by Blocking Cytokine Secretion by Oyaizu, Naoki, Closkey, Thomas W.Mc, Than, Soe, Pahwa, Savita

“…Evidence is accumulating that T cells from human immunodeficiency virus type 1 (HIV-1)-infected individuals show accelerated cell death through apoptosis. We…”
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Flow cytometry based procedures for the measurement of apoptosis applicable to the investigation of HIV infection by Mc Closkey, Thomas W., Pahwa, Savita

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