Search Results - "Clizbe, Lane A."

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-( N, N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor by Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J., Bauer, Shawn M., Goldman, Erick A., Probst, Gary D., Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W., Edwards, Susan T., Arfsten, Ann E., Clizbe, Lane A., Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M., Zhu, Bing-Yan

“…Systematic SAR studies of in vitro factor Xa inhibitory activity around compound 1 were performed by modifying each of the three phenyl rings. A class of…”
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Design, synthesis and structure–Activity relationships of benzoxazinone-Based factor Xa inhibitors by Huang, Wenrong, Zhang, Penglie, Zuckett, Jingmei F, Wang, Lingyan, Woolfrey, John, Song, Yonghong, Jia, Zhaozhong J, Clizbe, Lane A, Su, Ting, Tran, Katherine, Huang, Brian, Wong, Paul, Sinha, Uma, Park, Gary, Reed, Andrea, Malinowski, John, Hollenbach, Stanley J, Scarborough, Robert M, Zhu, Bing-Yan

“…A series of benzoxazinone derivatives was designed and synthesized as factor Xa inhibitors. We demonstrated that the naphthyl moiety in the aniline-based…”
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1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor xa inhibitors. Part 2: A survey of P4 motifs by JIA, Zhaozhong J, YANHONG WU, HUTCHALEELAHA, Athiwat, SCARBOROUGH, Robert M, ZHU, Bing-Yan, WENRONG HUANG, PENGLIE ZHANG, CLIZBE, Lane A, GOLDMAN, Erick A, SINHA, Uma, ARFSTEN, Ann E, EDWARDS, Susan T, ALPHONSO, Merlyn

“…A variety of P4 motifs have been examined to increase the binding affinity and in vitro anticoagulant potency of our biphenyl…”
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N, N-Dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines as potent factor Xa inhibitors by JIA, Zhaozhong J, TING SU, WENRONG HUANG, WOOLFREY, John, SINHA, Uma, ARFSTEN, Ann E, HUTCHALEELAHA, Athiwat, HOLLENBACH, Stanley J, LAMBING, Joseph L, SCARBOROUGH, Robert M, ZHU, Bing-Yan, ZUCKETT, Jingmei F, YANHONG WU, GOLDMAN, Erick A, WENHAO LI, PENGLIE ZHANG, CLIZBE, Lane A, YONGHONG SONG, BAUER, Shawn M

“…A class of N,N-dialkylated 4-(4-arylsulfonylpiperazine-1-carbonyl)-benzamidines and 4-((4-arylsulfonyl)-2-oxo-piperazin-1-ylmethyl)-benzamidines has been…”
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Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y12) by SCARBOROUGH, Robert M, LAIBELMAN, Alan M, CLIZBE, Lane A, FRETTO, Larry J, CONLEY, Pamela B, REYNOLDS, Elwood E, SEDLOCK, David M, JANTZEN, Hans-Michael

“…Novel non-nucleoside tricyclic platelet ADP receptor (P2Y(12)) antagonists have been discovered that bind reversibly and with high affinity to the platelet…”
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Thermal rearrangements of propargylic trichloroacetimidates. Synthesis of (trichloroacetamido)-1,3-dienes and -1,2-dienes by Overman, Larry E, Clizbe, Lane A, Freerks, Robert L, Marlowe, Charles K

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A simple synthesis of L-.gamma.-carboxyglutamate and derivatives thereof by Danishefsky, Samuel, Berman, Ellen, Clizbe, Lane A, Hirama, Masahiro

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Diels-Alder reactions of 1-(acylamino)-1,3-dienes by Overman, Larry E, Freerks, Robert L, Petty, C. Bruce, Clizbe, Lane A, Ono, Robert K, Taylor, Garry F, Jessup, Peter J

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Total synthesis of pretyrosine (arogenate) by Danishefsky, Samuel, Morris, Joel, Clizbe, Lane A

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Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido )-5-metho xybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor by Zhang, Penglie, Huang, Wenrong, Wang, Lingyan, Bao, Liang, Jia, Zhaozhong J, Bauer, Shawn M, Goldman, Erick A, Probst, Gary D, Song, Yonghong, Su, Ting, Fan, Jingmei, Wu, Yanhong, Li, Wenhao, Woolfrey, John, Sinha, Uma, Wong, Paul W, Edwards, Susan T, Arfsten, Ann E, Clizbe, Lane A, Kanter, James, Pandey, Anjali, Park, Gary, Hutchaleelaha, Athiwat, Lambing, Joseph L, Hollenbach, Stanley J, Scarborough, Robert M, Zhu, Bing-Yan

“…Systematic SAR studies of in vitro factor Xa inhibitory activity around compound 1 were performed by modifying each of the three phenyl rings. A class of…”
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1-(2-Naphthyl)-1 H -pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs by Jia, Zhaozhong J., Wu, Yanhong, Huang, Wenrong, Zhang, Penglie, Clizbe, Lane A., Goldman, Erick A., Sinha, Uma, Arfsten, Ann E., Edwards, Susan T., Alphonso, Merlyn, Hutchaleelaha, Athiwat, Scarborough, Robert M., Zhu, Bing-Yan

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A reevaluation of the Hofmann rearrangement in electron deficient systems: preparation of 2-(15N)-amino-4,6-dinitrotoluene and 4-(15N)-amino-2,6-dinitrotoluene by Spanggord, Ronald J., Clizbe, Lane A.

“…The Hofmann rearrangement is an excellent synthetic method to introduce amino functions into aromatic molecules; however, it becomes less efficient in…”
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Synthesis of trichloroacetamido-1,3-dienes. Useful aminobutadiene equivalents for the Diels-Alder reaction by Overman, Larry E., Clizbe, Lane A.

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Synthesis of [14C]anthracycline anticancer agent 14-O-(β-alanyl-N-HCl)-7-O-(2′,6′-dideoxy-2′-fluoro-α-l-talopyranosyl) adriamycinone-14-14C (DA-125-14C) by Rhee, Sung W., Ryan, Kenneth J., Tracy, Michael, Kelson, Andrew B., Clizbe, Lane A., Chang, Moon-Ho, Park, Jong-Sei, Roh, Jung-Koo, Kong, Jae-Yang, Yang, Jungick, Kim, Won-Bae, Ok, Kwang-Dae

“…Synthesis of the anthracycline anticancer agent, 14‐O‐(β‐alanyl‐N‐HCl)‐7‐O‐(2′,6′‐dideoxy‐2′‐fluoro‐α‐L‐talopyranosyl) Adriamycinone (DA‐125‐14C) labeled with…”
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Structure of elasnin, a novel elastase inhibitor by Omura, S, Nakagawa, A, Ohno, H

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The Conversion of L-Glutamate to L-Tyrosine by J. Danishefsky, Samuel, Morris, Joel, A. Clizbe, Lane

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