Search Results - "Clive, Derrick L. J"

Formation of Optically Pure Cyclic Amines by Intramolecular Conjugate Displacement by Cheng, Ping, Clive, Derrick L. J

“…Intramolecular conjugate displacement (ICD) has been applied to the Morita–Baylis–Hillman adducts formed from (5S)-5-(l-menthyloxy)-2(5H)-furanone and…”
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Asymmetric Synthesis of the ABC-Ring System of the Antitumor Antibiotic MPC1001 by Peng, Jianbiao, Clive, Derrick L. J

“…trans-4-Hydroxy-l-proline was converted into a tricyclic compound representing three contiguous rings of the anticancer antibiotic MPC1001. The tricyclic model…”
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Formation of Carbocycles by Intramolecular Conjugate Displacement: Scope and Mechanistic Insights by Wang, Lihong, Prabhudas, Bodhuri, Clive, Derrick L. J

“…A detailed study has been made of a method of ring closure categorized as an all-carbon intramolecular conjugate displacement (ICD). This reaction involves…”
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Total Synthesis of the Marine Alkaloid Halichlorine: Development and Use of a General Route to Chiral Piperidines by Liu, Dazhan, Acharya, Hukum P, Yu, Maolin, Wang, Jian, Yeh, Vince S. C, Kang, Shunzhen, Chiruta, Chandramouli, Jachak, Santosh M, Clive, Derrick L. J

“…The total synthesis of the marine alkaloid halichlorine is described, based on an approach that involves constructing the fully substituted asymmetric center…”
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Formation of Benzo-Fused Carbocycles by Formal Radical Cyclization onto an Aromatic Ring by Clive, Derrick L. J, Sunasee, Rajesh

“…An indirect method for effecting radical carbocyclization onto aromatic rings is described. Cross-conjugated dienones such as 13, readily prepared by Birch…”
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Synthesis of the Potent Anticancer Agents Ottelione A and Ottelione B in Both Racemic and Natural Optically Pure Forms by Clive, Derrick L. J., Liu, Dazhan

“…The powerful antitumor agents ottelione A and B were synthesized in racemic form by a method that relies on selective ring closing metathesis. Optically pure…”
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Formation of 3‑Aminophenols from Cyclohexane-1,3-diones by Szymor-Pietrzak, Damian, Khan, Muhammad N, Pagès, Anaïs, Kumar, Ajay, Depner, Noah, Clive, Derrick L. J

“…meta-Aminophenols are formed by the action of DBU on 3-amino-2-chlorocyclohex-2-en-1-ones at room temperature in MeCN. The chloro compounds are generated by…”
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Formation of Enol Ethers by Radical Decarboxylation of α‑Alkoxy β‑Phenylthio Acids by Palanivel, Ashokkumar, Mubeen, Sidra, Warner, Thomas, Ahmed, Nayeem, Clive, Derrick L. J

“…Enol ethers are formed by radical decarboxylation of α-alkoxy β-phenylthio acids via the corresponding Barton esters. The phenylthio acids were usually made by…”
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Synthetic Chemistry of Halichlorine and the Pinnaic Acids by Clive, Derrick L. J, Yu, Maolin, Wang, Jian, Yeh, Vince S. C, Kang, Shunzhen

“…Clive et al discuss synthetic work directed at the marine natural products halichlorine and the pinnaic acids--substances that have received a conspicuous…”
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Formation of meta-Substituted Phenols by Transition Metal-Free Aromatization: Use of 2‑Bromocyclohex-2-en-1-ones by Yu, Guojun, Clive, Derrick L. J

“…Addition of Grignard or other organometallic reagents to 2-halocyclohex-2-en-1-ones bearing an alkyl or aryl group at C-5, followed by mild acid treatment and…”
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Synthesis of the Otteliones A and B: Use of a Cyclopropyl Group as Both a Steric Shield and a Vinyl Equivalent by Clive, Derrick L. J., Liu, Dazhan

“…To A and B: The extremely powerful antitumor agents ottelione A and B have been synthesized from D‐ribose. Key steps in the synthesis involve the use of a…”
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Synthesis of (±)-Hamigeran B, (−)-Hamigeran B, and (±)-1-epi-Hamigeran B:  Use of Bulky Silyl Groups to Protect a Benzylic Carbon−Oxygen Bond from Hydrogenolysis by Clive, Derrick L. J, Wang, Jian

“…Enone 42 was converted into diene 56, which was then subjected to hydrogenation. Use of the tert-butyldimethylsiloxy groups enforces facial selectivity and…”
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Carbocyclization by Radical Closure onto O-Trityl Oximes:  Dramatic Effect of Diphenyl Diselenide by Clive, Derrick L. J, Pham, Mai P, Subedi, Rajendra

“…O-Trityl oximes of 5- and 6-iodoaldehydes undergo radical cyclization to produce oximes when treated in refluxing tetrahydrofuran (THF) with Bu3SnH,…”
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A Family of Routes to Substituted Phenols, Including Meta-Substituted Phenols by Shao, Wenjie, Clive, Derrick L. J

“…A new family of routes to substituted phenols has been developed. 2-Bromo-3-methoxycyclohex-2-en-1-ones are readily deprotonated at C-6, and the resulting…”
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Synthesis of Substituted Resorcinol Monomethyl Ethers from 2‑Bromo-3-methoxycyclohex-2-en-1-ones by Shao, Wenjie, Clive, Derrick L. J

“…2-Bromo-3-methoxycyclohex-2-en-1-ones are readily alkylated at C-6 with reactive halides, and then treatment with DBU (2 equiv) in PhMe at room temperature…”
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A General Route to 1,3′-Bipyrroles by Cheng, Ping, Shao, Wenjie, Clive, Derrick L. J

“…A general method is described for the synthesis of 1,3′-bipyrroles. The route involves constructing a pyrrole ring on the nitrogen of a substituted 1H-pyrrole,…”
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Synthesis of (+)-Ipalbidine Based on 6-exo-trig Radical Cyclization of a β‑Amino Radical by Chea, JongMyoung, Clive, Derrick L. J

“…N-Boc (S)-proline was converted into (2S)-2-[(phenylselanyl)­methyl]­pyrrolidine, which was alkylated on nitrogen with 2-bromo-1-(4-methoxyphenyl)­ethan-1-one…”
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Formal Radical Cyclization onto Benzene Rings:  A General Method and Its Use in the Synthesis of ent-Nocardione A by CLIVE, Derrick L. J., FLETCHER, Stephen P., LIU, Dazhan

“…An indirect method is described for effecting radical cyclization onto a benzene ring. Cross-conjugated dienones 6, which are readily prepared from phenols,…”
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Synthesis of Optically Pure (+)-Puraquinonic Acid and Assignment of Absolute Configuration to Natural (−)-Puraquinonic Acid. Use of Radical Cyclization for Asymmetric Generation of a Quaternary Center by Clive, Derrick L. J, Yu, Maolin, Sannigrahi, Mousumi

“…An asymmetric aldol reaction between aldehyde 31 and imide 32, followed at a later stage by ring-closing metathesis (38 → 40), are key reactions used to make…”
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Synthetic Studies on CP-225,917 and CP-263,114: Access to Advanced Tetracyclic Systems by Intramolecular Conjugate Displacement and [2,3]-Wittig Rearrangement by Malihi, Farzad, Clive, Derrick L. J, Chang, Che-Chien, Minaruzzaman

“…An advanced intermediate related to the structures of CP-225,917 and CP-263,114 was constructed by a sequence based on the use of Grob-like fragmentation,…”
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