Search Results - "Clinkenbeard, Erica L."

Excessive Osteocytic Fgf23 Secretion Contributes to Pyrophosphate Accumulation and Mineralization Defect in Hyp Mice by Murali, Sathish K, Andrukhova, Olena, Clinkenbeard, Erica L, White, Kenneth E, Erben, Reinhold G

“…X-linked hypophosphatemia (XLH) is the most frequent form of inherited rickets in humans caused by mutations in the phosphate-regulating gene with homologies…”
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Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia by Feng, Jian Q, Clinkenbeard, Erica L, Yuan, Baozhi, White, Kenneth E, Drezner, Marc K

“…Abstract Although recent studies have established that osteocytes function as secretory cells that regulate phosphate metabolism, the biomolecular mechanism(s)…”
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Chronic Hyperphosphatemia and Vascular Calcification Are Reduced by Stable Delivery of Soluble Klotho by Hum, Julia M, O'Bryan, Linda M, Tatiparthi, Arun K, Cass, Taryn A, Clinkenbeard, Erica L, Cramer, Martin S, Bhaskaran, Manoj, Johnson, Robert L, Wilson, Jonathan M, Smith, Rosamund C, White, Kenneth E

“…Klotho ( KL) regulates mineral metabolism, and diseases associated with KL deficiency are characterized by hyperphosphatemia and vascular calcification (VC)…”
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Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia by Clinkenbeard, Erica L, Cass, Taryn A, Ni, Pu, Hum, Julia M, Bellido, Teresita, Allen, Matthew R, White, Kenneth E

“…ABSTRACT The transgenic and knockout (KO) animals involving Fgf23 have been highly informative in defining novel aspects of mineral metabolism, but are limited…”
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Neonatal Iron Deficiency Causes Abnormal Phosphate Metabolism by Elevating FGF23 in Normal and ADHR Mice by Clinkenbeard, Erica L, Farrow, Emily G, Summers, Lelia J, Cass, Taryn A, Roberts, Jessica L, Bayt, Christine A, Lahm, Tim, Albrecht, Marjorie, Allen, Matthew R, Peacock, Munro, White, Kenneth E

“…ABSTRACT Fibroblast growth factor 23 (FGF23) gain of function mutations can lead to autosomal dominant hypophosphatemic rickets (ADHR) disease onset at birth,…”
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Generation of two multipotent mesenchymal progenitor cell lines capable of osteogenic, mature osteocyte, adipogenic, and chondrogenic differentiation by Prideaux, Matthew, Wright, Christian S., Noonan, Megan L., Yi, Xin, Clinkenbeard, Erica L., Mevel, Elsa, Wheeler, Jonathan A., Byers, Sharon, Wijenayaka, Asiri R., Gronthos, Stan, Sankar, Uma, White, Kenneth E., Atkins, Gerald J., Thompson, William R.

“…Mesenchymal progenitors differentiate into several tissues including bone, cartilage, and adipose. Targeting these cells in vivo is challenging, making…”
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Erythropoietin and a hypoxia‐inducible factor prolyl hydroxylase inhibitor (HIF‐PHDi) lowers FGF23 in a model of chronic kidney disease (CKD) by Noonan, Megan L., Clinkenbeard, Erica L., Ni, Pu, Swallow, Elizabeth A., Tippen, Samantha P., Agoro, Rafiou, Allen, Matthew R., White, Kenneth E.

“…Iron‐deficiency anemia is a potent stimulator of the phosphaturic hormone Fibroblast growth factor‐23 (FGF23). Anemia, elevated FGF23, and elevated serum…”
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Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23 by Noonan, Megan L, Ni, Pu, Solis, Emmanuel, Marambio, Yamil G, Agoro, Rafiou, Chu, Xiaona, Wang, Yue, Gao, Hongyu, Xuei, Xiaoling, Clinkenbeard, Erica L, Jiang, Guanglong, Liu, Sheng, Stegen, Steve, Carmeliet, Geert, Thompson, William R, Liu, Yunlong, Wan, Jun, White, Kenneth E

“…Osteocytes act within a hypoxic environment to control key steps in bone formation. FGF23, a critical phosphate-regulating hormone, is stimulated by low…”
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Differential Iron Requirements for Osteoblast and Adipocyte Differentiation by Edwards, Daniel F., Miller, Christopher J., Quintana‐Martinez, Arelis, Wright, Christian S., Prideaux, Matthew, Atkins, Gerald J., Thompson, William R., Clinkenbeard, Erica L.

“…ABSTRACT Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external…”
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Regulation of Fibroblast Growth Factor 23 by Iron, EPO, and HIF by Wheeler, Jonathan A., Clinkenbeard, Erica L.

“…Purpose of Review Fibroblast growth factor-23 (FGF23) is the key hormone produced in bone critical for phosphate homeostasis. Elevated serum phosphorus and…”
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Segregating the effects of ferric citrate‐mediated iron utilization and FGF23 in a mouse model of CKD by Liesen, Michael P., Noonan, Megan L., Ni, Pu, Agoro, Rafiou, Hum, Julia M., Clinkenbeard, Erica L., Damrath, John G., Wallace, Joseph M., Swallow, Elizabeth A., Allen, Matthew R., White, Kenneth E.

“…Ferric citrate (FC) is an approved therapy for chronic kidney disease (CKD) patients as a phosphate (Pi) binder for dialysis‐dependent CKD, and for iron…”
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Adiposity and Mineral Balance in Chronic Kidney Disease by Hosain, Ozair, Clinkenbeard, Erica L.

“…Purpose of Review Bone homeostasis is balanced between formation and resorption activities and remain in relative equilibrium. Under disease states this…”
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The metabolic bone disease associated with the Hyp mutation is independent of osteoblastic HIF1α expression by Hum, Julia M, Clinkenbeard, Erica L, Ip, Colin, Cass, Taryn A, Allen, Matt, White, Kenneth E

“…Fibroblast growth factor-23 (FGF23) controls key responses to systemic phosphate increases through its phosphaturic actions on the kidney. In addition to…”
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Suppression of Sost/Sclerostin and Dickkopf‐1 Augment Intervertebral Disc Structure in Mice by Kroon, Tori, Bhadouria, Neharika, Niziolek, Paul, Edwards, Daniel, Choi, Roy, Clinkenbeard, Erica L, Robling, Alexander, Holguin, Nilsson

“…ABSTRACT Intervertebral disc (IVD) degeneration is a leading cause of low back pain, characterized by accelerated extracellular matrix breakdown and IVD height…”
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Heritable and acquired disorders of phosphate metabolism: Etiologies involving FGF23 and current therapeutics by Clinkenbeard, Erica L., White, Kenneth E.

“…Phosphate is critical for many cellular processes and structural functions, including as a key molecule for nucleic acid synthesis and energy metabolism, as…”
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The HIF‐PHI BAY 85‐3934 (Molidustat) Improves Anemia and Is Associated With Reduced Levels of Circulating FGF23 in a CKD Mouse Model by Noonan, Megan L, Ni, Pu, Agoro, Rafiou, Sacks, Spencer A, Swallow, Elizabeth A, Wheeler, Jonathan A, Clinkenbeard, Erica L, Capitano, Maegan L, Prideaux, Matthew, Atkins, Gerald J, Thompson, William R, Allen, Matthew R, Broxmeyer, Hal E, White, Kenneth E

“…ABSTRACT Fibroblast growth factor‐23 (FGF23) is a critical factor in chronic kidney disease (CKD), with elevated levels causing alterations in mineral…”
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Liver size and lipid content differences between BALB/c and BALB/cJ mice on a high-fat diet are due, in part, to Zhx2 by Clinkenbeard, Erica L., Turpin, Courtney, Jiang, Jieyun, Peterson, Martha L., Spear, Brett T.

“…BALB/cJ mice exhibit considerable phenotypic differences with other BALB/c substrains. Some of these traits involve the liver, including persistent postnatal…”
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Erythropoietin stimulates murine and human fibroblast growth factor-23, revealing novel roles for bone and bone marrow by Clinkenbeard, Erica L, Hanudel, Mark R, Stayrook, Keith R, Appaiah, Hitesh Nidumanda, Farrow, Emily G, Cass, Taryn A, Summers, Lelia J, Ip, Colin S, Hum, Julia M, Thomas, Joseph C, Ivan, Mircea, Richine, Briana M, Chan, Rebecca J, Clemens, Thomas L, Schipani, Ernestina, Sabbagh, Yves, Xu, Linlin, Srour, Edward F, Alvarez, Marta B, Kacena, Melissa A, Salusky, Isidro B, Ganz, Tomas, Nemeth, Elizabeta, White, Kenneth E

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Effects of ferric citrate and intravenous iron sucrose on markers of mineral, bone, and iron homeostasis in a rat model of CKD-MBD by Biruete, Annabel, Metzger, Corinne E, Chen, Neal X, Swallow, Elizabeth A, Vrabec, Curtis, Clinkenbeard, Erica L, Stacy, Alexander J, Srinivasan, Shruthi, O'Neill, Kalisha, Avin, Keith G, Allen, Matthew R, Moe, Sharon M

“…Anemia and chronic kidney disease-mineral and bone disorder (CKD-MBD) are common and begin early in CKD. Limited studies have concurrently compared the effects…”
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Circulating αKlotho influences phosphate handling by controlling FGF23 production by Smith, Rosamund C, O'Bryan, Linda M, Farrow, Emily G, Summers, Lelia J, Clinkenbeard, Erica L, Roberts, Jessica L, Cass, Taryn A, Saha, Joy, Broderick, Carol, Ma, Y Linda, Zeng, Qing Qiang, Kharitonenkov, Alexei, Wilson, Jonathan M, Guo, Qianxu, Sun, Haijun, Allen, Matthew R, Burr, David B, Breyer, Matthew D, White, Kenneth E

“…The FGF23 coreceptor αKlotho (αKL) is expressed as a membrane-bound protein (mKL) that forms heteromeric complexes with FGF receptors (FGFRs) to initiate…”
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