Search Results - "Clinical drug investigation"

Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review by Plantone, Domenico, Koudriavtseva, Tatiana

“…The process of finding new therapeutic indications for currently used drugs, defined as ‘repurposing’, is receiving growing attention. Chloroquine and…”
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Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia by Zhang, Shengyu, Li, Lei, Shen, Aizong, Chen, Yongwu, Qi, Zhigang

“…Since December 2019, a novel coronavirus pneumonia (COVID-19) has broken out in Wuhan, China and spread rapidly. Recent studies have found that ⁓ 15.7% of…”
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The Safety of Melatonin in Humans by Andersen, Lars Peter Holst, Gögenur, Ismail, Rosenberg, Jacob, Reiter, Russel J.

“…Exogenous melatonin has been investigated as treatment for a number of medical and surgical diseases, demonstrating encouraging results. The aim of this review…”
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Azithromycin for COVID-19: More Than Just an Antimicrobial? by Bleyzac, Nathalie, Goutelle, Sylvain, Bourguignon, Laurent, Tod, Michel

“…Most of them evaluate established antiviral drugs such as lopinavir/ritonavir, and chloroquine (CQ) or its derivative hydroxychloroquine (HCQ), which have…”
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An Updated Systematic Review of the Therapeutic Role of Hydroxychloroquine in Coronavirus Disease-19 (COVID-19) by Das, Saibal, Bhowmick, Subhrojyoti, Tiwari, Sayali, Sen, Sukanta

“…Background and Objective The world is currently experiencing the Coronavirus Disease-19 (COVID-19) pandemic. There is no approved drug for the definitive…”
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Adverse Event Profiles of Anti-CTLA-4 and Anti-PD-1 Monoclonal Antibodies Alone or in Combination: Analysis of Spontaneous Reports Submitted to FAERS by Ji, Huan-huan, Tang, Xue-wen, Dong, Zhi, Song, Lin, Jia, Yun-tao

“…Background and Objective Immune checkpoint inhibitors (ICIs)—cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death receptor-1 (PD-1) monoclonal…”
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Management of Left Ventricular Thrombi with Direct Oral Anticoagulants: Retrospective Comparative Study with Vitamin K Antagonists by Daher, Jessica, Da Costa, Antoine, Hilaire, Christophe, Ferreira, Thomas, Pierrard, Romain, Guichard, Jean Baptiste, Romeyer, Cécile, Isaaz, Karl

“…Background and Objectives The efficacy of direct oral anticoagulants (DOACs) in the management of left ventricular (LV) thrombi remains to be determined,…”
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Impact of Body Mass Index on the Efficacy of Biological Therapies in Patients with Psoriasis: A Real-World Study by Pirro, Federico, Caldarola, Giacomo, Chiricozzi, Andrea, Burlando, Martina, Mariani, Marco, Parodi, Aurora, Peris, Ketty, De Simone, Clara

“…Background The efficacy of biological therapies used for the treatment of chronic plaque psoriasis can be influenced by numerous variables including  body mass…”
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The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder by De Aquino, Joao P., Parida, Suprit, Sofuoglu, Mehmet

“…Although expanding the availability of buprenorphine—a first-line pharmacotherapy for opioid-use disorder (OUD)—has increased the capacity of healthcare…”
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Riboflavin in Neurological Diseases: A Narrative Review by Plantone, Domenico, Pardini, Matteo, Rinaldi, Giuseppe

“…Riboflavin is classified as one of the water-soluble B vitamins. It is part of the functional group of flavin mononucleotide (FMN) and flavin adenine…”
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Observational Study of Chlorpromazine in Hospitalized Patients with COVID-19 by Hoertel, Nicolas, Sánchez-Rico, Marina, Vernet, Raphaël, Jannot, Anne-Sophie, Neuraz, Antoine, Blanco, Carlos, Lemogne, Cédric, Airagnes, Guillaume, Paris, Nicolas, Daniel, Christel, Gramfort, Alexandre, Lemaitre, Guillaume, Bernaux, Mélodie, Bellamine, Ali, Beeker, Nathanaël, Limosin, Frédéric

“…Introduction Chlorpromazine has been suggested as being potentially useful in patients with coronavirus disease 2019 (COVID-19) on the grounds of its potential…”
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Gut Microbiome in Psoriasis is Perturbed Differently During Secukinumab and Ustekinumab Therapy and Associated with Response to Treatment by Yeh, Nai-Lun, Hsu, Che-Yuan, Tsai, Tsen-Fang, Chiu, Hsien-Yi

“…Background and Objective Immunotherapy could change the complex host-microbial interactions. We aimed to investigate the dynamics of gut microbiome in response…”
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Safety, Tolerability, and Pharmacokinetics of the Novel Anti-influenza Agent Baloxavir Marboxil in Healthy Adults: Phase I Study Findings by Koshimichi, Hiroki, Ishibashi, Toru, Kawaguchi, Nao, Sato, Chisako, Kawasaki, Akira, Wajima, Toshihiro

“…Background and Objective Baloxavir marboxil, a prodrug that is metabolized to baloxavir acid, suppresses viral replication by inhibiting cap-dependent…”
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Lecanemab: More Questions Than Answers by Kaur, Upinder, Reddy, Jaideep, Tiwari, Ashutosh, Chakrabarti, Sasanka, Chakrabarti, Sankha Shubhra

“…The approval of lecanemab by the US Food and Drug Administration has been touted as a defining moment in the treatment of Alzheimer’s disease. Lecanemab, an…”
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Glucagon-Like Peptide-1 Receptor Analogues in Type 2 Diabetes: Their Use and Differential Features by Lyseng-Williamson, Katherine A

“…Glucagon-like peptide-1 receptor analogues/agonists (GLP-1RAs) are well established as effective adjuncts to lifestyle modification in the treatment of type 2…”
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Second-Generation Antipsychotic Drugs for Patients with Schizophrenia: Systematic Literature Review and Meta-analysis of Metabolic and Cardiovascular Side Effects by Rognoni, Carla, Bertolani, Arianna, Jommi, Claudio

“…Background and Objectives Second-generation antipsychotics (SGAs) for schizophrenia show different risk profiles, whose evidence has been evaluated through…”
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Real-Life Experience of Tralokinumab for the Treatment of Adult Patients with Severe Atopic Dermatitis: A Multicentric Prospective Study by De Greef, Axel, Ghislain, Pierre-Dominique, Bulinckx, Audrey, Coster, Alison, de Halleux, Céline, Damsin, Thomas, Jacobs, Marie-Claude, Suys, Erwin, Zoghaib, Samer, Baeck, Marie

“…Background Tralokinumab, the first fully human monoclonal antibody that binds specifically to interleukin-13, was safe and effective for treating atopic…”
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The Respimat® Soft Mist Inhaler: Implications of Drug Delivery Characteristics for Patients by Iwanaga, Takashi, Tohda, Yuji, Nakamura, Shuhei, Suga, Yasunori

“…Successful treatment for respiratory diseases relies on effective delivery of medication to the lungs using an inhalation device. Different inhalers have…”
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Paxlovid-Tacrolimus Drug–Drug Interaction in a 23-Year-Old Female Kidney Transplant Patient with COVID-19 by Berar Yanay, Noa, Bogner, Ido, Saker, Khader, Tannous, Elias

“…Kidney transplant patients are at a high risk for adverse severe acute respiratory syndrome coronavirus 2 (SARSCOV-2) infection outcomes in terms of morbidity…”
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Cannabidiol in the Treatment of Epilepsy by von Wrede, Randi, Helmstaedter, Christoph, Surges, Rainer

“…Anecdotal reports addressing the successful seizure treatment of severe epilepsies with cannabidiol (CBD) have increased both public interest and academic…”
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