Search Results - "Clinical and translational medicine"

Single‐cell RNA sequencing technologies and applications: A brief overview by Jovic, Dragomirka, Liang, Xue, Zeng, Hua, Lin, Lin, Xu, Fengping, Luo, Yonglun

“…Single‐cell RNA sequencing (scRNA‐seq) technology has become the state‐of‐the‐art approach for unravelling the heterogeneity and complexity of RNA transcripts…”
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Cancer nanomedicine: a review of recent success in drug delivery by Tran, Stephanie, DeGiovanni, Peter-Joseph, Piel, Brandon, Rai, Prakash

“…Cancer continues to be one of the most difficult global healthcare problems. Although there is a large library of drugs that can be used in cancer treatment,…”
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Anti‐inflammatory hydrogel dressings and skin wound healing by Huang, Can, Dong, Lanlan, Zhao, Baohua, Lu, Yifei, Huang, Shurun, Yuan, Zhiqiang, Luo, Gaoxing, Xu, Yong, Qian, Wei

“…Hydrogels are promising and widely utilized in the biomedical field. In recent years, the anti‐inflammatory function of hydrogel dressings has been…”
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A perspective on multi-target drug discovery and design for complex diseases by Ramsay, Rona R., Popovic-Nikolic, Marija R., Nikolic, Katarina, Uliassi, Elisa, Bolognesi, Maria Laura

“…Diseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative…”
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2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies by She, Jun, Jiang, Jinjun, Ye, Ling, Hu, Lijuan, Bai, Chunxue, Song, Yuanlin

“…An ongoing outbreak of 2019-nCoV pneumonia was first identified in Wuhan, Hubei province, China at the end of 2019. With the spread of the new coronavirus…”
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Pyroptosis, metabolism, and tumor immune microenvironment by Du, Tiantian, Gao, Jie, Li, Peilong, Wang, Yunshan, Qi, Qiuchen, Liu, Xiaoyan, Li, Juan, Wang, Chuanxin, Du, Lutao

“…In response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of…”
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Analyses of repeated failures in cancer therapy for solid tumors: poor tumor-selective drug delivery, low therapeutic efficacy and unsustainable costs by Maeda, Hiroshi, Khatami, Mahin

“…For over six decades reductionist approaches to cancer chemotherapies including recent immunotherapy for solid tumors produced outcome failure-rates of 90%…”
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Significance of long chain polyunsaturated fatty acids in human health by Zárate, Rafael, el Jaber-Vazdekis, Nabil, Tejera, Noemi, Pérez, José A., Rodríguez, Covadonga

“…In the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding…”
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Cytosolic DNA‐STING‐NLRP3 axis is involved in murine acute lung injury induced by lipopolysaccharide by Ning, Li, Wei, Wang, Wenyang, Jiang, Rui, Xiong, Qing, Geng

“…The role of NOD‐like receptor protein 3 (NLRP3)‐mediated pyroptosis in acute lung injury (ALI) has been well identified previously. Stimulator of interferon…”
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The role of CD133 in cancer: a concise review by Glumac, Paige M., LeBeau, Aaron M.

“…Despite the abundant ongoing research efforts, cancer remains one of the most challenging diseases to treat globally. Due to the heterogenous nature of cancer,…”
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CD73 alleviates GSDMD‐mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling by Xu, Shun, Wang, Jin, Zhong, Junjie, Shao, Minghao, Jiang, Jianyuan, Song, Jian, Zhu, Wei, Zhang, Fan, Xu, Haocheng, Xu, Guangyu, Zhang, Yuxuan, Ma, Xiaosheng, Lyu, Feizhou

“…Background Neuroinflammation‐induced secondary injury is an important cause of sustained progression of spinal cord injury. Inflammatory programmed cell death…”
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Emerging roles of exosomal miRNAs in diabetes mellitus by He, Xiaoyun, Kuang, Gaoyan, Wu, Yongrong, Ou, Chunlin

“…Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by almost all cell types. Exosomes can carry diverse cargo including RNA,…”
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Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis by Zhang, Hao, Wang, Yanghanzhao, Qu, Mengdi, Li, Wenqian, Wu, Dan, Cata, Juan P., Miao, Changhong

“…Sepsis is a persistent systemic inflammatory condition involving multiple organ failures resulting from a dysregulated immune response to infection, and one of…”
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Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer by Chirshev, Evgeny, Oberg, Kerby C., Ioffe, Yevgeniya J., Unternaehrer, Juli J.

“…Abnormal regulation and expression of microRNAs (miRNAs) has been documented in various diseases including cancer. The miRNA let - 7 (MIRLET7) family controls…”
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EMT and tumor metastasis by Heerboth, Sarah, Housman, Genevieve, Leary, Meghan, Longacre, Mckenna, Byler, Shannon, Lapinska, Karolina, Willbanks, Amber, Sarkar, Sibaji

“…EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development…”
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METTL1 promotes hepatocarcinogenesis via m7G tRNA modification‐dependent translation control by Chen, Zhihang, Zhu, Wanjie, Zhu, Shenghua, Sun, Kaiyu, Liao, Junbin, Liu, Haining, Dai, Zihao, Han, Hui, Ren, Xuxin, Yang, Qingxia, Zheng, Siyi, Peng, Baogang, Peng, Sui, Kuang, Ming, Lin, Shuibin

“…Background N7‐methylguanosine (m7G) modification is one of the most common transfer RNA (tRNA) modifications in humans. The precise function and molecular…”
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Tumor‐derived exosomal miR‐19b‐3p facilitates M2 macrophage polarization and exosomal LINC00273 secretion to promote lung adenocarcinoma metastasis via Hippo pathway by Chen, Jing, Zhang, Kai, Zhi, Yingru, Wu, Yin, Chen, Baoan, Bai, Jinyu, Wang, Xuerong

“…Numerous reports have elucidated the important participation of exosomes in the communication between tumor cells and other cancer‐related cells including…”
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Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin‐induced cardiotoxicity by Hu, Can, Zhang, Xin, Zhang, Ning, Wei, Wen‐Ying, Li, Ling‐Li, Ma, Zhen‐Guo, Tang, Qi‐Zhu

“…Background Inflammation, oxidative stress, and apoptosis contribute to the evolution of doxorubicin (DOX)‐induced cardiotoxicity. Osteocrin (OSTN) is a novel…”
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The potential impact of ChatGPT in clinical and translational medicine by Xue, Vivian Weiwen, Lei, Pinggui, Cho, William C.

“…AI models may help in clinical decision support, clinical trial recruitment, clinical data management, research support, patient education and other fields.5,6…”
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Autophagy and inflammation by Qian, Mengjia, Fang, Xiaocong, Wang, Xiangdong

“…Autophagy is a homeostatic mechanism involved in the disposal of damaged organelles, denatured proteins as well as invaded pathogens through a lysosomal…”
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