Search Results - "Clinical and experimental pharmacology & physiology"

Molecular mechanisms for tumour resistance to chemotherapy by Pan, Shu-Ting, Li, Zhi-Ling, He, Zhi-Xu, Qiu, Jia-Xuan, Zhou, Shu-Feng

“…Summary Chemotherapy is one of the prevailing methods used to treat malignant tumours, but the outcome and prognosis of tumour patients are not optimistic…”
Get full text

Discovery of curcumin, a component of golden spice, and its miraculous biological activities by Gupta, Subash C, Patchva, Sridevi, Koh, Wonil, Aggarwal, Bharat B

“…Summary 1. Curcumin is the active ingredient of the dietary spice turmeric and has been consumed for medicinal purposes for thousands of years. Modern science…”
Get full text

Paracetamol – An old drug with new mechanisms of action by Przybyła, Grzegorz W., Szychowski, Konrad A., Gmiński, Jan

“…Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in the world. Despite its popularity and use for many years, the safety of…”
Get full text

Hypoxia‐inducible factors as neuroprotective agent in Alzheimer's disease by Ashok, Ben Sundra, Ajith, Thekkuttuparambil Ananthanarayanan, Sivanesan, Senthilkumar

“…Summary Beta amyloid (Aβ)‐42 peptide and phosphorylated tau protein have been demonstrated as the pathological hallmarks of Alzheimer's disease (AD). A gradual…”
Get full text

The potential actions of angiotensin‐converting enzyme II (ACE2) activator diminazene aceturate (DIZE) in various diseases by Qaradakhi, Tawar, Gadanec, Laura Kate, McSweeney, Kristen Renee, Tacey, Alexander, Apostolopoulos, Vasso, Levinger, Itamar, Rimarova, Kvetoslava, Egom, Emmanuel E., Rodrigo, Luis, Kruzliak, Peter, Kubatka, Peter, Zulli, Anthony

“…The renin angiotensin system (RAS) regulates fluid balance, blood pressure and maintains vascular tone. The potent vasoconstrictor angiotensin II (Ang II)…”
Get full text

Metabolic endotoxemia and cardiovascular disease: A systematic review about potential roles of prebiotics and probiotics by Moludi, Jalal, Maleki, Vahid, Jafari‐Vayghyan, Hamed, Vaghef‐Mehrabany, Elnaz, Alizadeh, Mohammad

“…Translocation of microbiome‐derived lipopolysaccharide (LPS) to the bloodstream (metabolic endotoxaemia) is associated with a significantly increased risk of…”
Get full text

Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis by Hariyanto, Timotius Ivan, Halim, Devina Adella, Jodhinata, Claudia, Yanto, Theo Audi, Kurniawan, Andree

“…Currently, there is no widely acceptable and proven effective treatment for coronavirus disease 2019 (COVID‐19). Colchicine has been shown to offer a benefit…”
Get full text

NF‐κB as the mediator of metformin's effect on ageing and ageing‐related diseases by Kanigur Sultuybek, Gönül, Soydas, Tugba, Yenmis, Guven

“…Summary Ageing can be defined as the progressive failure of repair and maintenance systems with a consequent accumulation of cellular damage in nucleic acids,…”
Get full text

Naegleria fowleri: Sources of infection, pathophysiology, diagnosis, and management; a review by Jahangeer, Muhammad, Mahmood, Zahed, Munir, Naveed, Waraich, Umm‐e‐Amara, Tahir, Imtiaz Mahmood, Akram, Muhammad, Ali Shah, Syed Muhammad, Zulfqar, Ayesha, Zainab, Rida

“…Naegleria fowleri, a thermophilic flagellate amoeba known as a “brain‐eating” amoeba, is the aetiological agent of a perilous and devastating waterborne…”
Get full text

Role of omega‐6 and omega‐3 fatty acids in fetal programming by Shrestha, Nirajan, Sleep, Simone L., Cuffe, James S.M., Holland, Olivia J., Perkins, Anthony V., Yau, Suk Yu, McAinch, Andrew J., Hryciw, Deanne H.

“…Maternal nutrition plays a critical role in fetal development and can influence adult onset of disease. Linoleic acid (LA) and alpha‐linolenic acid (ALA) are…”
Get full text

Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy by Fisher, Joshua J., Bartho, Lucy A., Perkins, Anthony V., Holland, Olivia J.

“…Mitochondria are central to cell function. The placenta forms the interface between maternal and fetal systems, and placental mitochondria have critical roles…”
Get full text

The role of galectin‐3 in heart failure and cardiovascular disease by Zhong, Xiao, Qian, Xiaoqian, Chen, Guangping, Song, Xiang

“…Summary Galectin‐3, a β‐galactoside‐binding lectin, is a new important player in the progression of heart failure (HF) and is also linked to poor outcome in…”
Get full text

Increased PD‐L1 expression in breast and colon cancer stem cells by Wu, Yanheng, Chen, Mingshui, Wu, Peihong, Chen, Chen, Xu, Zhi Ping, Gu, Wenyi

“…Summary Here we report the expression of programmed cell death ligand 1/2 (PD‐L1/L2) in breast and colon cancer stem cells (CSCs). The stemness of these cells…”
Get full text

Autophagy in vascular endothelial cells by Jiang, Fan

“…Summary The importance of autophagy in cardiovascular physiology and cardiovascular disease is increasingly recognized; however, the precise biological effects…”
Get full text

Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus by Guo, Min, Mi, Jia, Jiang, Qiu-Ming, Xu, Jin-Mei, Tang, Ying-Ying, Tian, Geng, Wang, Bin

“…Summary Diabetes mellitus and depressive disorders are both common chronic diseases that increase functional disability and social burden. Cognitive impairment…”
Get full text

Metformin alleviates renal injury in diabetic rats by inducing Sirt1/FoxO1 autophagic signal axis by Xu, Jiang, Liu, Lin‐Qing, Xu, Lin‐Lin, Xing, Yan, Ye, Shandong

“…Diabetic nephropathy (DN) is the major microvascular complication of diabetes mellitus and the most important cause of end‐stage renal disease worldwide…”
Get full text

Haemodynamic influences on kidney oxygenation: Clinical implications of integrative physiology by Evans, Roger G, Ince, Can, Joles, Jaap A, Smith, David W, May, Clive N, O'Connor, Paul M, Gardiner, Bruce S

“…Summary Renal blood flow, local tissue perfusion and blood oxygen content are the major determinants of oxygen delivery to kidney tissue. Arterial pressure and…”
Get full text

Role of melatonin in blood pressure regulation: An adjunct anti‐hypertensive agent by Baker, Jacquie, Kimpinski, Kurt

“…Summary Cardiovascular diseases account for approximately one‐third of all deaths each year. Of this, hypertension accounts for approximately 9.4 million…”
Get full text

A comprehensive review on medicinal plants possessing antioxidant potential by Zafar, Farah, Asif, Hafiz Muhammad, Shaheen, Ghazala, Ghauri, Aymen Owais, Rajpoot, Sehrish Rana, Tasleem, Muhammad Wasim, Shamim, Tahira, Hadi, Faheem, Noor, Raessa, Ali, Tanveer, Gulzar, Muhammad Nauman, Nazar, Halima

“…Many research studies have proposed that about two‐thirds of the medicinal plant species of the world possess significant antioxidant potential. Antioxidants…”
Get full text

A role for retinoids in the treatment of COVID‐19? by Trasino, Steven E.

“…The 2020 global outbreak of the novel coronavirus (SARS‐CoV‐2 or COVID‐19) is a serious threat to international health, and thus, there is an urgent need for…”
Get full text