Search Results - "Clinical Biochemistry"

The multiple functions and mechanisms of osteopontin by Icer, Mehmet Arif, Gezmen-Karadag, Makbule

“…Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic characteristics and rich in aspartic acid. OPN, a multifunctional protein, has…”
Get full text

Neuro-inflammation and anti-inflammatory treatment options for Alzheimer's disease by Ozben, Tomris, Ozben, Serkan

“…Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive memory loss and dementia. The pathological characteristics of AD include…”
Get full text

After another decade: LC–MS/MS became routine in clinical diagnostics by Seger, Christoph, Salzmann, Linda

“…•The application of mass spectrometry in clinical routine is discussed.•An overview of instrument and platform improvement is given.•Legal boundaries of lab…”
Get full text

A novel and automated assay for thiol/disulphide homeostasis by Erel, Ozcan, Neselioglu, Salim

“…To develop a novel and automated assay determining plasma thiol/disulphide homeostasis, which consists of thiol–disulphide exchanges. Native thiol and total…”
Get full text

Laboratory abnormalities in children with mild and severe coronavirus disease 2019 (COVID-19): A pooled analysis and review by Henry, Brandon Michael, Benoit, Stefanie W., de Oliveira, Maria Helena Santos, Hsieh, Wan Chin, Benoit, Justin, Ballout, Rami A., Plebani, Mario, Lippi, Giuseppe

“…•No clear pattern of leukocyte abnormalities is seen in children with COVID-19.•Leukocyte counts may not be a reliable marker of pediatric COVID-19…”
Get full text

Hair cortisol analysis: An update on methodological considerations and clinical applications by Greff, Michael J.E., Levine, Jeffrey M., Abuzgaia, Awatif M., Elzagallaai, Abdelbaset A., Rieder, Michael J., van Uum, Stan H.M.

“…Hair cortisol analysis is increasingly being appreciated and applied in both research and medicine, aiding endocrinologists with diagnosis. We provide an…”
Get full text

Are antioxidant enzymes essential markers in the diagnosis and monitoring of cancer patients – A review by Cecerska-Heryć, Elżbieta, Surowska, Oliwia, Heryć, Rafał, Serwin, Natalia, Napiontek-Balińska, Sylwia, Dołęgowska, Barbara

“…•Non-small-cell lung cancer is usually characterized by decreased SOD and CAT activity and increased glutathione GST activity. Lowered SOD, CAT, and GPx…”
Get full text

Clinical aspects of Alzheimer's disease by Zvěřová, Martina

“…Alzheimer's disease is a progressive, irreversible, incurable, neurodegenerative illness and the most common of the dementing disorders. It starts usually…”
Get full text

Gut–liver axis, nutrition, and non-alcoholic fatty liver disease by Kirpich, Irina A., Marsano, Luis S., McClain, Craig J.

“…Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of diseases involving hepatic fat accumulation, inflammation with the potential progression to…”
Get full text

Roles of matrix metalloproteinase-7 (MMP-7) in cancer by Liao, Hai-Yang, Da, Chao-Ming, Liao, Bei, Zhang, Hai-Hong

“…•This paper reviews the recent literature on MMP-7.•According to the MMP-7 in cancers, the role of MMP-7 on cancer field was summarized.•MMP-7 is a potential…”
Get full text

Alzheimer's disease and other neurodegenerative dementias in comorbidity: A clinical and neuropathological overview by Matej, Radoslav, Tesar, Adam, Rusina, Robert

“…Neuropathological diagnostic criteria of neurodegenerative disorders are based on the presence of specific inclusions in a specific area of brain tissue that…”
Get full text

Electrolyte imbalances in patients with severe coronavirus disease 2019 (COVID-19) by Lippi, Giuseppe, South, Andrew M, Henry, Brandon Michael

“…Early studies have reported various electrolyte abnormalities at admission in patients who progress to the severe form of coronavirus disease 2019 (COVID-19)…”
Get more information

Neutrophil to lymphocyte ratio predict mortality and major adverse cardiac events in acute coronary syndrome: A systematic review and meta-analysis by Dong, Chao-Hui, Wang, Zhang-Min, Chen, Si-Yu

“…Neutrophil to lymphocyte ratio (NLR) might be associated with the mortality or major adverse cardiac events (MACEs) in acute coronary syndrome (ACS) patients…”
Get full text

Comparative analysis of circulating tumor DNA stability In K3EDTA, Streck, and CellSave blood collection tubes by Kang, Qing, Henry, N. Lynn, Paoletti, Costanza, Jiang, Hui, Vats, Pankaj, Chinnaiyan, Arul M., Hayes, Daniel F., Merajver, Sofia D., Rae, James M., Tewari, Muneesh

“…Optimal conditions for blood collection for circulating tumor DNA (ctDNA) are still being developed. Although both Streck and EDTA tubes are commonly used,…”
Get full text

The bone remodelling cycle by Kenkre, J S, Bassett, Jhd

“…The bone remodelling cycle replaces old and damaged bone and is a highly regulated, lifelong process essential for preserving bone integrity and maintaining…”
Get more information

Data science, artificial intelligence, and machine learning: Opportunities for laboratory medicine and the value of positive regulation by Gruson, Damien, Helleputte, Thibault, Rousseau, Patrick, Gruson, David

“…Artificial intelligence (AI) and data science are rapidly developing in healthcare, as is their translation into laboratory medicine. Our review article…”
Get full text

IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays by Apple, Fred S., Jaffe, Allan S., Collinson, Paul, Mockel, Martin, Ordonez-Llanos, Jordi, Lindahl, Bertil, Hollander, Judd, Plebani, Mario, Than, Martin, Chan, M.H.M.

“…In 2011, the IFCC Task Force on Clinical Applications of Cardiac Bio-Markers (TF-CB) was formed, with the purpose of providing evidence based educational…”
Get full text

Current use of bone turnover markers in the management of osteoporosis by Brown, Jacques P., Don-Wauchope, Andrew, Douville, Pierre, Albert, Caroline, Vasikaran, Samuel D.

“…•Standardized preanalytical procedures are important to minimise variability of BTMs.•Performance of automated assays (PINP and CTX) are acceptable for routine…”
Get full text

CRISPR-based tools: Alternative methods for the diagnosis of COVID-19 by Palaz, Fahreddin, Kalkan, Ali Kerem, Tozluyurt, Abdullah, Ozsoz, Mehmet

“…•Testing for SARS-CoV-2 is crucial as it enables the detection and isolation of infected individuals.•Although RT-qPCR is the gold standard method for COVID-19…”
Get full text

Lipase or amylase for the diagnosis of acute pancreatitis? by Ismail, Ola Z., Bhayana, Vipin

“…Acute pancreatitis is a rapid onset of inflammation of the pancreas causing mild to severe life threatening conditions [1, 2]. In Canada, acute pancreatitis is…”
Get full text