Search Results - "Clingen, Peter H"

Phase I Study of Sequence-Selective Minor Groove DNA Binding Agent SJG-136 in Patients with Advanced Solid Tumors by HOCHHAUSER, Daniel, MEYER, Timothy, JODRELL, Duncan, SPANSWICK, VictoriaJ, WU, Jenny, CLINGEN, Peter H, LOADMAN, Paul, COBB, Margaret, GUMBRELL, Lindsey, BEGENT, Richard H, HARTLEY, John A

“…Purpose: This phase I dose-escalation study was undertaken to establish the maximum tolerated dose of the sequence-selective minor groove DNA binding agent…”
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Mice Lacking Neutrophil Elastase Are Resistant to Bleomycin-Induced Pulmonary Fibrosis by Chua, Felix, Dunsmore, Sarah E, Clingen, Peter H, Mutsaers, Steven E, Shapiro, Steven D, Segal, Anthony W, Roes, Jürgen, Laurent, Geoffrey J

“…Neutrophil elastase is a serine protease stored in the azurophilic granules of leukocytes. It has been implicated in the pathology of several lung diseases and…”
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γ-H2AX Foci Formation as a Pharmacodynamic Marker of DNA Damage Produced by DNA Cross-Linking Agents: Results from 2 Phase I Clinical Trials of SJG-136 (SG2000) by WU, Jenny, CLINGEN, Peter H, SPANSWICK, Victoria J, MELLINAS-GOMEZ, Maria, MEYER, Tim, PUZANOV, Igor, JODRELL, Duncan, HOCHHAUSER, Daniel, HARTLEY, John A

“…To evaluate γ-H2AX foci as a pharmacodynamic marker for DNA damage induced by DNA interstrand cross-linking drugs. γ-H2AX foci formation was validated…”
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Defining the Roles of Nucleotide Excision Repair and Recombination in the Repair of DNA Interstrand Cross-Links in Mammalian Cells by De Silva, Inusha U., McHugh, Peter J., Clingen, Peter H., Hartley, John A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity. Part 1: Cellular pharmacology, in vitro and initial in vivo antitumor activity by HARTLEY, John A, SPANSWICK, Victoria J, HOLLINGSHEAD, Melinda G, SCHWEIKART, Karen M, TOMASZEWSKI, Joseph E, SAUSVILLE, Edward A, GREGSON, Stephen J, HOWARD, Philip W, THURSTON, David E, BROOKS, Natalie, CLINGEN, Peter H, MCHUGH, Peter J, HOCHHAUSER, Daniel, PEDLEY, R. Barbara, KELLAND, Lloyd R, ALLEY, Michael C, SCHULTZ, Robert

“…SJG-136 (NSC 694501) is a rationally designed pyrrolobenzodiazepine dimer that binds in the minor groove of DNA. It spans 6 bp with a preference for binding to…”
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Ultraviolet-B-Induced Apoptosis and Cytokine Release in Xeroderma Pigmentosum Keratinocytes by Capulas, Emily, Lowe, Jillian E., Green, Michael H.L., Arlett, Colin F., Petit-Frère, Corinne, Clingen, Peter H., Koulu, Leena, Marttila, Reijo J., Jaspers, Nicolaas G.J.

“…We have assessed the ability of xeroderma pigmentosum and normal keratinocytes grown out from skin biopsies to undergo apoptosis after irradiation with…”
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A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum by Abbaszadeh, Fatemeh, Clingen, Peter H, Arlett, Colin F, Plowman, Piers N, Bourton, Emma C, Themis, Matthew, Makarov, Evgeny M, Newbold, Robert F, Green, Michael H L, Parris, Christopher N

“…Radiotherapy-induced DNA double-strand breaks (DSBs) are critical cytotoxic lesions. Inherited defects in DNA DSB repair pathways lead to hypersensitivity to…”
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Defects in interstrand cross‐link uncoupling do not account for the extreme sensitivity of ERCC1 and XPF cells to cisplatin by De Silva, Inusha U., McHugh, Peter J., Clingen, Peter H., Hartley, John A.

“…The anticancer drug cisplatin reacts with DNA leading to the formation of interstrand and intrastrand cross‐links that are the critical cytotoxic lesions. In…”
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The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136 by Clingen, Peter H., De Silva, Inusha U., McHugh, Peter J., Ghadessy, Farid J, Tilby, Michael J., Thurston, David E., Hartley, John A.

“…SJG-136, a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer, is a highly efficient interstrand crosslinking agent that reacts with guanine bases in a 5′-GATC-3′…”
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Chemosensitivity of primary human fibroblasts with defective unhooking of DNA interstrand cross-links by Clingen, Peter H., Arlett, Colin F., Hartley, John A., Parris, Christopher N.

“…Xeroderma pigmentosum (XP) is characterised by defects in nucleotide excision repair, ultraviolet (UV) radiation sensitivity and increased skin carcinoma…”
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Apoptosis and cytokine release induced by ionizing or ultraviolet B radiation in primary and immortalized human keratinocytes by Petit-Frère, Corinne, Capulas, Emily, Lyon, Debbie A., Norbury, Christopher J., Lowe, Jillian E., Clingen, Peter H., Riballo, Enriqueta, Green, Michael H. L., Arlett, Colin F.

“…We have compared the induction of apoptosis and cytokine release by UVB and γ-radiation in primary (untransformed) and in two immortalized human…”
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Induction of cyclobutane pyrimidine dimers, pyrimidine(6-4)pyrimidone photoproducts, and Dewar valence isomers by natural sunlight in normal human mononuclear cells by Clingen, P H, Arlett, C F, Roza, L, Mori, T, Nikaido, O, Green, M H

“…Immunocytochemistry was used for the direct measurement of cyclobutane pyrimidine dimers, (6-4) photoproducts, and Dewar isomers in normal human mononuclear…”
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The cancer-free phenotype in trichothiodystrophy is unrelated to its repair defect by BERNEBURG, M, CLINGEN, P. H, HARCOURT, S. A, LOWE, J. E, TAYLOR, E. M, GREEN, M. H. L, KRUTMANN, J, ARLETT, C. F, LEHMANN, A. R

“…The DNA repair-deficient genetic disorders xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) can both result from mutations in the XPD gene, the sites…”
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Possible Effects of Sunlight on Human Lymphocytes by Green, Michael H. L., Petit-Frere, Corinne, Clingen, Peter H., Bentham, Graham, Cole, Jane, Arlett, Colin F.

“…The human population is exposed to both the ultraviolet A (UVA) and B (UVB) regions of the solar spectrum. UVB induces mainly dipyrimidine photoproducts in DNA…”
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γ-H2AX foci formation as a pharmacodynamic marker of DNA damage produced by DNA cross-linking agents: results from two Phase I clinical trials of SJG-136 (SG2000) by Wu, Jenny, Clingen, Peter H, Spanswick, Victoria J, Mellinas-Gomez, Maria, Meyer, Tim, Puzanov, Igor, Jodrell, Duncan, Hochhauser, Daniel, Hartley, John A

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Apoptosis and cytokine release induced by ionizing or ultraviolet B radiation in primary and immortalized human keratinocytes by PETIT-FRERE, C, CAPULAS, E, LYON, D. A, NORBURY, C. J, LOWE, J. E, CLINGEN, P. H, RIBALLO, E, GREEN, M. H. L, ARLETT, C. F

“…We have compared the induction of apoptosis and cytokine release by UVB and gamma-radiation in primary (untransformed) and in two immortalized human…”
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Induction of Interleukin-6 Production by Ultraviolet Radiation in Normal Human Epidermal Keratinocytes and in a Human Keratinocyte Cell Line is Mediated by DNA Damage by Petit-FrèrePeter, Corinne, Clingen, Petit H., Arlett, Colin F., Green, Michael H.L., Grewe, Markus, Krutmann, Jean, Roza, Len

“…The sunburn reaction is the most common consequence of human exposure to ultraviolet radiation (UVR), and is mediated at least in part by interleukin-6 (IL-6)…”
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SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity by Hartley, John A., Spanswick, Victoria J., Brooks, Natalie, Clingen, Peter H., McHugh, Peter J., Hochhauser, Daniel, Pedley, R. Barbara, Kelland, Lloyd R., Alley, Michael C., Schultz, Robert, Hollingshead, Melinda G., Schweikart, Karen M., Tomaszewski, Joseph E., Sausville, Edward A., Gregson, Stephen J., Howard, Philip W., Thurston, David E

“…Abstract SJG-136 (NSC 694501) is a rationally designed pyrrolobenzodiazepine dimer that binds in the minor groove of DNA. It spans 6 bp with a preference for…”
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Quantum yields of adenine photodimerization in poly (deoxyadenylic acid) and DNA by Clingen, Peter H., Jeremy, R., Davies, H.

“…The photodimerization of adjacent adenine bases on the same polydeoxyribonucleotide strand gives rise to two distinct dimeric photoadducts, designated A=A and…”
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Defining the Roles of Nucleotide Excision Repair and Recombination in the Repair of DNA Interstrand Cross-Links in Mammalian Cells by De Silva, Inusha U., McHugh, Peter J., Clingen, Peter H., Hartley, John A.

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