Search Results - "Cline, W."

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease by Luukkonen, Panu K., Dufour, Sylvie, Lyu, Kun, Zhang, Xian-Man, Hakkarainen, Antti, Lehtimäki, Tiina E., Cline, Gary W., Petersen, Kitt Falk, Shulman, Gerald I., Yki-Järvinen, Hannele

“…Weight loss by ketogenic diet (KD) has gained popularity in management of nonalcoholic fatty liver disease (NAFLD). KD rapidly reverses NAFLD and insulin…”
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Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes by Perry, Rachel J., Camporez, João-Paulo G., Kursawe, Romy, Titchenell, Paul M., Zhang, Dongyan, Perry, Curtis J., Jurczak, Michael J., Abudukadier, Abulizi, Han, Myoung Sook, Zhang, Xian-Man, Ruan, Hai-Bin, Yang, Xiaoyong, Caprio, Sonia, Kaech, Susan M., Sul, Hei Sook, Birnbaum, Morris J., Davis, Roger J., Cline, Gary W., Petersen, Kitt Falk, Shulman, Gerald I.

“…Impaired insulin-mediated suppression of hepatic glucose production (HGP) plays a major role in the pathogenesis of type 2 diabetes (T2D), yet the molecular…”
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Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation by Perry, Rachel J., Wang, Yongliang, Cline, Gary W., Rabin-Court, Aviva, Song, Joongyu D., Dufour, Sylvie, Zhang, Xian Man, Petersen, Kitt Falk, Shulman, Gerald I.

“…The transition from the fed to the fasted state necessitates a shift from carbohydrate to fat metabolism that is thought to be mostly orchestrated by…”
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Acetyl‐CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents by Goedeke, Leigh, Bates, Jamie, Vatner, Daniel F., Perry, Rachel J., Wang, Ting, Ramirez, Ricardo, Li, Li, Ellis, Matthew W., Zhang, Dongyan, Wong, Kari E., Beysen, Carine, Cline, Gary W., Ray, Adrian S., Shulman, Gerald I.

“…Pharmacologic inhibition of acetyl‐CoA carboxylase (ACC) enzymes, ACC1 and ACC2, offers an attractive therapeutic strategy for nonalcoholic fatty liver disease…”
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Integrated, Step-Wise, Mass-Isotopomeric Flux Analysis of the TCA Cycle by Alves, Tiago C., Pongratz, Rebecca L., Zhao, Xiaojian, Yarborough, Orlando, Sereda, Sam, Shirihai, Orian, Cline, Gary W., Mason, Graeme, Kibbey, Richard G.

“…Mass isotopomer multi-ordinate spectral analysis (MIMOSA) is a step-wise flux analysis platform to measure discrete glycolytic and mitochondrial metabolic…”
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Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids by Vatner, Daniel F., Majumdar, Sachin K., Kumashiro, Naoki, Petersen, Max C., Rahimi, Yasmeen, Gattu, Arijeet K., Bears, Mitchell, Camporez, João-Paulo G., Cline, Gary W., Jurczak, Michael J., Samuel, Varman T., Shulman, Gerald I.

“…A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin resistance—wherein insulin fails to suppress hepatic glucose…”
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Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis by Perry, Rachel J, Peng, Liang, Abulizi, Abudukadier, Kennedy, Lynn, Cline, Gary W, Shulman, Gerald I

“…The mechanism by which leptin reverses diabetic ketoacidosis (DKA) is unknown. We examined the acute insulin-independent effects of leptin replacement therapy…”
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Metabolic control analysis of hepatic glycogen synthesis in vivo by Nozaki, Yuichi, Petersen, Max C., Zhang, Dongyan, Vatner, Daniel F., Perry, Rachel J., Abulizi, Abudukadier, Haedersdal, Sofie, Zhang, Xian-Man, Butrico, Gina M., Samuel, Varman T., Mason, Graeme F., Cline, Gary W., Petersen, Kitt F., Rothman, Douglas L., Shulman, Gerald I.

“…Multiple insulin-regulated enzymes participate in hepatic glycogen synthesis, and the rate-controlling step responsible for insulin stimulation of glycogen…”
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Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes by Perry, Rachel J., Peng, Liang, Cline, Gary W., Wang, Yongliang, Rabin-Court, Aviva, Song, Joongyu D., Zhang, Dongyan, Zhang, Xian-Man, Nozaki, Yuichi, Dufour, Sylvie, Petersen, Kitt Falk, Shulman, Gerald I.

“…Caloric restriction rapidly reverses type 2 diabetes (T2D), but the mechanism(s) of this reversal are poorly understood. Here we show that 3 days of a…”
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Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler by Perry, Rachel J., Kim, Taehan, Zhang, Xian-Man, Lee, Hui-Young, Pesta, Dominik, Popov, Violeta B., Zhang, Dongyan, Rahimi, Yasmeen, Jurczak, Michael J., Cline, Gary W., Spiegel, David A., Shulman, Gerald I.

“…Nonalcoholic fatty liver disease (NAFLD) affects one in three Americans and is a major predisposing condition for the metabolic syndrome and type 2 diabetes…”
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role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome by Petersen, Kitt Falk, Dufour, Sylvie, Savage, David B, Bilz, Stefan, Solomon, Gina, Yonemitsu, Shin, Cline, Gary W, Befroy, Douglas, Zemany, Laura, Kahn, Barbara B, Papademetris, Xenophon, Rothman, Douglas L, Shulman, Gerald I

“…We examined the hypothesis that insulin resistance in skeletal muscle promotes the development of atherogenic dyslipidemia, associated with the metabolic…”
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Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages by Araldi, Elisa, Fernández-Fuertes, Marta, Canfrán-Duque, Alberto, Tang, Wenwen, Cline, Gary W., Madrigal-Matute, Julio, Pober, Jordan S., Lasunción, Miguel A., Wu, Dianqing, Fernández-Hernando, Carlos, Suárez, Yajaira

“…Macrophages perform critical functions in both innate immunity and cholesterol metabolism. Here, we report that activation of Toll-like receptor 4 (TLR4) in…”
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Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance by Petersen, Kitt Falk, Befroy, Douglas, Dufour, Sylvie, Dziura, James, Ariyan, Charlotte, Rothman, Douglas L., DiPietro, Loretta, Cline, Gary W., Shulman, Gerald I.

“…Insulin resistance is a major factor in the pathogenesis of type 2 diabetes in the elderly. To investigate how insulin resistance arises, we studied healthy,…”
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Hypophosphatemia promotes lower rates of muscle ATP synthesis by Pesta, Dominik H., Tsirigotis, Dimitrios N., Befroy, Douglas E., Caballero, Daniel, Jurczak, Michael J., Rahimi, Yasmeen, Cline, Gary W., Dufour, Sylvie, Birkenfeld, Andreas L., Rothman, Douglas L., Carpenter, Thomas O., Insogna, Karl, Petersen, Kitt Falk, Bergwitz, Clemens, Shulman, Gerald I.

“…ABSTRACT Hypophosphatemia can lead to muscle weakness and respiratory and heart failure, but the mechanism is unknown. To address this question, we…”
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Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference by Song, Joongyu D., Alves, Tiago C., Befroy, Douglas E., Perry, Rachel J., Mason, Graeme F., Zhang, Xian-Man, Munk, Alexander, Zhang, Ye, Zhang, Dongyan, Cline, Gary W., Rothman, Douglas L., Petersen, Kitt Falk, Shulman, Gerald I.

“…Alterations in muscle mitochondrial substrate preference have been postulated to play a major role in the pathogenesis of muscle insulin resistance. In order…”
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Effect of aging on muscle mitochondrial substrate utilization in humans by Petersen, Kitt Falk, Morino, Katsutaro, Alves, Tiago C., Kibbey, Richard G., Dufour, Sylvie, Sono, Saki, Yoo, Peter S., Cline, Gary W., Shulman, Gerald I.

“…Previous studies have implicated age-associated reductions in mitochondrial oxidative phosphorylation activity in skeletal muscle as a predisposing factor for…”
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A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo by Perry, Rachel J., Peng, Liang, Cline, Gary W., Petersen, Kitt Falk, Shulman, Gerald I.

“…Acetyl-coenzyme A (acetyl-CoA) is a critical metabolic signaling molecule that regulates gluconeogenesis, pyruvate oxidation, protein acetylation, and steroid…”
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A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis by Stark, Romana, Guebre-Egziabher, Fitsum, Zhao, Xiaojian, Feriod, Colleen, Dong, Jianying, Alves, Tiago C., Ioja, Simona, Pongratz, Rebecca L., Bhanot, Sanjay, Roden, Michael, Cline, Gary W., Shulman, Gerald I., Kibbey, Richard G.

“…Synthesis of phosphoenolpyruvate (PEP) from oxaloacetate is an absolute requirement for gluconeogenesis from mitochondrial substrates. Generally, this reaction…”
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Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA) by Perry, Rachel J., Peng, Liang, Cline, Gary W., Butrico, Gina M., Wang, Yongliang, Zhang, Xian-Man, Rothman, Douglas L., Petersen, Kitt Falk, Shulman, Gerald I.

“…Hepatic mitochondria play a central role in the regulation of intermediary metabolism and maintenance of normoglycemia, and there is great interest in…”
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Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes by Petersen, Kitt Falk, Dufour, Sylvie, Morino, Katsutaro, Yoo, Peter S, Cline, Gary W, Shulman, Gerald I

“…To examine the role of intramyocellular lipid (IMCL) accumulation as well as circulating cytokines, branched-chain amino acids and acylcarnitines in the…”
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