Search Results - "Cline, Susan D."

Mitochondrial DNA damage and its consequences for mitochondrial gene expression by Cline, Susan D.

“…How mitochondria process DNA damage and whether a change in the steady-state level of mitochondrial DNA damage (mtDNA) contributes to mitochondrial dysfunction…”
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Regulation of the vapBC-1 toxin-antitoxin locus in nontypeable Haemophilus influenzae by Cline, Susan D, Saleem, Sehresh, Daines, Dayle A

“…Nontypeable Haemophilus influenzae (NTHi) are human-adapted commensal bacteria that can cause a number of chronic mucosal infections, including otitis media…”
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Malondialdehyde Adducts in DNA Arrest Transcription by T7 RNA Polymerase and Mammalian RNA Polymerase II by Cline, Susan D., Riggins, James N., Tornaletti, Silvia, Marnett, Lawrence J., Hanawalt, Philip C.

“…Malondialdehyde, a genotoxic byproduct of lipid peroxidation, reacts with guanine in DNA to form pyrimido[1,2-α]purin-10(3H)-one ( M1 dG), the first endogenous…”
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Widespread increases in malondialdehyde immunoreactivity in dopamine-rich and dopamine-poor regions of rat brain following multiple, high doses of methamphetamine by Horner, Kristen A, Gilbert, Yamiece E, Cline, Susan D

“…Treatment with multiple high doses of methamphetamine (METH) can induce oxidative damage, including dopamine (DA)-mediated reactive oxygen species (ROS)…”
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DNA Topoisomerase II as the Target for the Anticancer Drug TOP-53:  Mechanistic Basis for Drug Action by Byl, Jo Ann Wilson, Cline, Susan D, Utsugi, Teruhiro, Kobunai, Takashi, Yamada, Yuji, Osheroff, Neil

“…TOP-53 is a promising anticancer agent that displays high activity against non-small cell lung cancer in animal tumor models [Utsugi, T., et al. (1996) Cancer…”
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Who's on first in the cellular response to DNA damage? by Hanawalt, Philip C, Cline, Susan D

“…Cellular DNA-repair pathways involve proteins that have roles in other DNA-metabolic processes, as well as those that are dedicated to damage removal. Several…”
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Mitochondrial gene expression by Cameron, Craig E, Cline, Susan D

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DNA Abasic Lesions in a Different Light:  Solution Structure of an Endogenous Topoisomerase II Poison by Cline, Susan D, Jones, Wendelyn R, Stone, Michael P, Osheroff, Neil

“…Topoisomerase II is the target for several anticancer drugs that “poison” the enzyme and convert it to a cellular toxin by increasing topoisomerase II-mediated…”
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Teaching Biochemistry to Students of Dentistry, Medicine, and Pharmacy: 7th International Conference of the Association of Biochemistry Educators (ABE) Tucson, AZ, USA, May 5–9, 2019 by Cline, Susan D., Simmons, Jana M., Niederhoffer, Eric C., Cruthirds, Danielle L., Arbor, Sage C., Franklin, David S., Abali, Emine E., Bateman, Robert C., Fontes, Joseph D., Lindsley, Janet E., Rubenstein, Peter A., Symes, Karen, Viselli, Susan M.

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Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M₁dG by Cline, Susan D, Lodeiro, M. Fernanda, Marnett, Lawrence J, Cameron, Craig E, Arnold, Jamie J

“…The biological aldehydes, malondialdehyde and base propenal, react with DNA to form a prevalent guanine adduct, M₁dG. The exocyclic ring of M₁dG opens to the…”
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Arrest of human mitochondrial RNA polymerase transcription by the biological aldehyde adduct of DNA, M 1 dG by Cline, Susan D., Lodeiro, M. Fernanda, Marnett, Lawrence J., Cameron, Craig E., Arnold, Jamie J.

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Teaching Biochemistry and Genetics to Students of Dentistry, Medicine, and Pharmacy 6th International Conference of the Association of Biochemistry Educators (ABE) Clearwater Beach, FL, USA, May 7-11, 2017 by Niederhoffer, Eric C, Cline, Susan D, Osheroff, Neil, Simmons, Jana M, Diekman, Alan B, Franklin, David S, Abali, Emine E, Bateman, Robert C, Fontes, Joseph D, Lindsley, Janet E, Pearson, David, Rubenstein, Peter A, Slaughter, Clive A, Bernstein, Jonathan A, Hyland, Katherine M, Park, Vicki M, Sobering, Andrew K, Weiler, Tracey A, Dasgupta, Shoumita

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Teaching Biochemistry to Students of Medicine, Pharmacy and Dentistry: 5th International Conference of the Association of Biochemistry Course Directors (ABCD) Santa Fe, NM, USA, May 3–7, 2015 by Osheroff, Neil, Niederhoffer, Eric C., Sabina, Richard L., Cline, Susan D., Wimmer, Mary J., Franklin, David S., Diekman, Alan B., Hogg, Tanis, Kearney, Kevin R., King, Steven C., Pearson, David, Slaughter, Clive A., Thompson, Kathryn

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Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy by Mayorov, Vladimir I, Lowrey, Angela J, Biousse, Valerie, Newman, Nancy J, Cline, Susan D, Brown, Michael D

“…Autosomal dominant optic atrophy (ADOA), a form of progressive bilateral blindness due to loss of retinal ganglion cells and optic nerve deterioration, arises…”
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Topoisomerase deficiencies subtly enhance global genomic repair of ultraviolet-induced DNA damage in Saccharomyces cerevisiae by Cline, Susan D., Hanawalt, Philip C.

“…Genetic integrity depends upon the precision of all pathways that manipulate DNA. DNA repair mechanisms prevent mutations and aberrant recombination events by…”
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Cytosine Arabinoside Lesions Are Position-specific Topoisomerase II Poisons and Stimulate DNA Cleavage Mediated by the Human Type II Enzymes by Cline, Susan D., Osheroff, Neil

“…Cytosine arabinoside (araC) is an important drug used for the treatment of human leukemias. In order to exert its cytotoxic effects, araC must be incorporated…”
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Azatoxin Is a Mechanistic Hybrid of the Topoisomerase II-Targeted Anticancer Drugs Etoposide and Ellipticine by Cline, Susan D, Macdonald, Timothy L, Osheroff, Neil

“…One approach to broadening the diversity of topoisomerase II-targeted anticancer agents is to generate novel compounds by combining structural elements of…”
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Disruption of mitochondrial DNA polymerase γ replication by the aldehyde adduct of DNA, M1dG by Cline, Susan D., Marnett, Lawrence J., Copeland, William C.

“…M1dG is a mutagenic adduct generated in human nuclear and mitochondrial DNA (mtDNA) by reaction of the cellular peroxidation products, malondialdehyde and base…”
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A novel role for the VapB‐2 antitoxin of nontypeable Haemophilus influenzae in genomic stability following oxidative stress by Ren, Dabin, Cline, Susan D., Bell, Clem, Daines, Dayle A.

“…Nontypeable Haemophilus influenzae (NTHi) are small Gram‐negative human‐adapted organisms that can cause a number of infections ranging from chronic bronchitis…”
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What Nutrition-Related Knowledge, Skills, and Attitudes Should Medical Students Develop? by Lindsley, Janet E., Abali, Emine Ercikan, Bikman, Benjamin T., Cline, Susan D., Fulton, Tracy, Lopez, Blanca, Rosenthal, Oren D., Uhley, Virginia E., Weintraut, Roberta J., Pauline Williams, D., Wisco, Jonathan J., Thompson, Kathryn

“…Nutrition is a significant determinant in the leading causes of death in the USA, and yet recent studies have shown that most American medical schools provide…”
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