Search Results - "Cline, Joel"

Role of the Beta and Gamma Isoforms of the Adapter Protein SH2B1 in Regulating Energy Balance by Argetsinger, Lawrence S, Flores, Anabel, Svezhova, Nadezhda, Ellis, Michael, Reynolds, Caitlin, Cote, Jessica L, Cline, Joel M, Myers, Martin G, Carter-Su, Christin

“…Abstract Human variants of the adapter protein SH2B1 are associated with severe childhood obesity, hyperphagia, and insulin resistance—phenotypes mimicked by…”
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Human SH2B1 mutations are associated with maladaptive behaviors and obesity by Doche, Michael E, Bochukova, Elena G, Su, Hsiao-Wen, Pearce, Laura R, Keogh, Julia M, Henning, Elana, Cline, Joel M, Saeed, Sadia, Dale, Anne, Cheetham, Tim, Barroso, Inês, Argetsinger, Lawrence S, O'Rahilly, Stephen, Rui, Liangyou, Carter-Su, Christin, Farooqi, I Sadaf

“…Src homology 2 B adapter protein 1 (SH2B1) modulates signaling by a variety of ligands that bind to receptor tyrosine kinases or JAK-associated cytokine…”
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The nucleolar δ isoform of adapter protein SH2B1 enhances morphological complexity and function of cultured neurons by Cote, Jessica L, Vander, Paul B, Ellis, Michael, Cline, Joel M, Svezhova, Nadezhda, Doche, Michael E, Maures, Travis J, Choudhury, Tahrim A, Kong, Seongbae, Klaft, Olivia G J, Joe, Ray M, Argetsinger, Lawrence S, Carter-Su, Christin

“…The adapter protein SH2B1 is recruited to neurotrophin receptors, including TrkB (also known as NTRK2), the receptor for brain-derived neurotrophic factor…”
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Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance by Flores, Anabel, Argetsinger, Lawrence S, Stadler, Lukas K J, Malaga, Alvaro E, Vander, Paul B, DeSantis, Lauren C, Joe, Ray M, Cline, Joel M, Keogh, Julia M, Henning, Elana, Barroso, Ines, Mendes de Oliveira, Edson, Chandrashekar, Gowri, Clutter, Erik S, Hu, Yixin, Stuckey, Jeanne, Farooqi, I Sadaf, Myers, Jr, Martin G, Carter-Su, Christin

“…Disruption of the adaptor protein SH2B1 (SH2-B, PSM) is associated with severe obesity, insulin resistance, and neurobehavioral abnormalities in mice and…”
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Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity by Cote, Jessica L, Argetsinger, Lawrence S, Flores, Anabel, Rupp, Alan C, Cline, Joel M, DeSantis, Lauren C, Bedard, Alexander H, Bagchi, Devika P, Vander, Paul B, Cacciaglia, Abrielle M, Clutter, Erik S, Chandrashekar, Gowri, MacDougald, Ormond A, Myers, Jr, Martin G, Carter-Su, Christin

“…Mice lacking SH2B1 and humans with variants of SH2B1 display severe obesity and insulin resistance. SH2B1 is an adapter protein that is recruited to the…”
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Recent Trends in Variable Generation Forecasting and Its Value to the Power System by Orwig, Kirsten D., Hamann, Hendrik F., Hodge, Bri-Mathias, Finley, Catherine, Nakafuji, Dora, Peterson, Jack, Maggio, David, Marquis, Melinda, Ahlstrom, Mark L., Banunarayanan, Venkat, Sharp, Justin, Wilczak, James M., Freedman, Jeffrey, Haupt, Sue Ellen, Cline, Joel, Bartholomy, Obadiah

“…The rapid deployment of wind and solar energy generation systems has resulted in a need to better understand, predict, and manage variable generation. The…”
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Phosphorylation of the Unique C-Terminal Tail of the Alpha Isoform of the Scaffold Protein SH2B1 Controls the Ability of SH2B1α To Enhance Nerve Growth Factor Function by Joe, Ray M., Flores, Anabel, Doche, Michael E., Cline, Joel M., Clutter, Erik S., Vander, Paul B., Riedel, Heimo, Argetsinger, Lawrence S., Carter-Su, Christin

“…The scaffold protein SH2B1, a major regulator of body weight, is recruited to the receptors of multiple cytokines and growth factors, including nerve growth…”
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Functional Characterization of Obesity-Associated Variants Involving the α and β Isoforms of Human SH2B1 by Pearce, Laura R, Joe, Ray, Doche, Michael E, Su, Hsiao-Wen, Keogh, Julia M, Henning, Elana, Argetsinger, Lawrence S, Bochukova, Elena G, Cline, Joel M, Garg, Sumedha, Saeed, Sadia, Shoelson, Steven, O'Rahilly, Stephen, Barroso, Inês, Rui, Liangyou, Farooqi, I. Sadaf, Carter-Su, Christin

“…We have previously reported rare variants in sarcoma (Src) homology 2 (SH2) B adaptor protein 1 (SH2B1) in individuals with obesity, insulin resistance, and…”
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Tyrosines 868, 966, and 972 in the Kinase Domain of JAK2 Are Autophosphorylated and Required for Maximal JAK2 Kinase Activity by Argetsinger, Lawrence S, Stuckey, Jeanne A, Robertson, Scott A, Koleva, Rositsa I, Cline, Joel M, Marto, Jarrod A, Myers, Martin G, Carter-Su, Christin

“…Janus kinase 2 (JAK2) is activated by a majority of cytokine family receptors including receptors for GH, leptin, and erythropoietin. To identify novel…”
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Large-eddy simulation sensitivities to variations of configuration and forcing parameters in canonical boundary-layer flows for wind energy applications by Mirocha, Jeffrey D, Churchfield, Matthew J, Muñoz-Esparza, Domingo, Rai, Raj K, Feng, Yan, Kosović, Branko, Haupt, Sue Ellen, Brown, Barbara, Ennis, Brandon L, Draxl, Caroline, Javier Sanz Rodrigo, Shaw, William J, Berg, Larry K, Moriarty, Patrick J, Linn, Rodman R, Kotamarthi, Veerabhadra R, Balakrishnan, Ramesh, Cline, Joel W, Robinson, Michael C, Ananthan, Shreyas

“…The sensitivities of idealized large-eddy simulations (LESs) to variations of model configuration and forcing parameters on quantities of interest to wind…”
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Phosphorylation of JAK2 at Serine 523: a Negative Regulator of JAK2 That Is Stimulated by Growth Hormone and Epidermal Growth Factor by Mazurkiewicz-Munoz, Anna M, Argetsinger, Lawrence S, Kouadio, Jean-Louis K, Stensballe, Allan, Jensen, Ole N, Cline, Joel M, Carter-Su, Christin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Structure–Activity Relationships of Natural and Semisynthetic Plecomacrolides Suggest Distinct Pathways for HIV‑1 Immune Evasion and Vacuolar ATPase-Dependent Lysosomal Acidification by McCauley, Morgan, Huston, Matthew, Condren, Alanna R., Pereira, Filipa, Cline, Joel, Yaple-Maresh, Marianne, Painter, Mark M., Zimmerman, Gretchen E., Robertson, Andrew W., Carney, Nolan, Goodall, Christopher, Terry, Valeri, Müller, Rolf, Sherman, David H., Collins, Kathleen L.

“…The human immunodeficiency virus (HIV)-encoded accessory protein Nef enhances pathogenicity by reducing major histocompatibility complex I (MHC-I) cell surface…”
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IMPROVING WIND ENERGY FORECASTING THROUGH NUMERICAL WEATHER PREDICTION MODEL DEVELOPMENT by Olson, Joseph B., Kenyon, Jaymes S., Djalalova, Irina, Bianco, Laura, Turner, David D., Pichugina, Yelena, Choukulkar, Aditya, Toy, Michael D., Brown, John M., Angevine, Wayne M., Akish, Elena, Bao, Jian-Wen, Jimenez, Pedro, Kosovic, Branko, Lundquist, Katherine A., Draxl, Caroline, Lundquist, Julie K., McCaa, Jim, McCaffrey, Katherine, Lantz, Kathy, Long, Chuck, Wilczak, Jim, Banta, Robert, Marquis, Melinda, Redfern, Stephanie, Berg, Larry K., Shaw, Will, Cline, Joel

“…The primary goal of the Second Wind Forecast Improvement Project (WFIP2) is to advance the state-of-the-art of wind energy forecasting in complex terrain. To…”
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THE SECOND WIND FORECAST IMPROVEMENT PROJECT (WFIP2): General Overview by Shaw, William J., Berg, Larry K., Cline, Joel, Draxl, Caroline, Djalalova, Irina, Grimit, Eric P., Lundquist, Julie K., Marquis, Melinda, McCaa, Jim, Olson, Joseph B., Sivaraman, Chitra, Sharp, Justin, Wilczak, James M.

“…Energy (DOE) initiated a 4-yr study, the Second Wind Forecast Improvement Project (WFIP2), to improve the representation of boundary layer physics and related…”
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ON BRIDGING A MODELING SCALE GAP: Mesoscale to Microscale Coupling for Wind Energy by Haupt, Sue Ellen, Kosovic, Branko, Shaw, William, Berg, Larry K., Churchfield, Matthew, Cline, Joel, Draxl, Caroline, Ennis, Brandon, Koo, Eunmo, Kotamarthi, Rao, Mazzaro, Laura, Mirocha, Jeffrey, Moriarty, Patrick, Muñoz-Esparza, Domingo, Quon, Eliot, Rai, Raj K., Robinson, Michael, Sever, Gokhan

“…Accurately representing flow across the mesoscale to the microscale is a persistent roadblock for completing realistic microscale simulations. The science…”
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THE SECOND WIND FORECAST IMPROVEMENT PROJECT (WFIP2): Observational Field Campaign by Wilczak, James M., Stoelinga, Mark, Berg, Larry K., Sharp, Justin, Draxl, Caroline, McCaffrey, Katherine, Banta, Robert M., Bianco, Laura, Djalalova, Irina, Lundquist, Julie K., Muradyan, Paytsar, Choukulkar, Aditya, Leo, Laura, Bonin, Timothy, Pichugina, Yelena, Eckman, Richard, Long, Charles N., Lantz, Kathleen, Worsnop, Rochelle P., Bickford, Jim, Bodini, Nicola, Chand, Duli, Clifton, Andrew, Cline, Joel, Cook, David R., Fernando, Harindra J. S., Friedrich, Katja, Krishnamurthy, Raghavendra, Marquis, Melinda, McCaa, Jim, Olson, Joseph B., Otarola-Bustos, Sebastian, Scott, George, Shaw, William J., Wharton, Sonia, White, Allen B.

“…The Second Wind Forecast Improvement Project (WFIP2) is a U.S. Department of Energy (DOE)- and National Oceanic and Atmospheric Administration (NOAA)-funded…”
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Pathology in Practice by Cline, Joel L., Lockaby, Susan B.

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THE WIND FORECAST IMPROVEMENT PROJECT (WFIP): A Public–Private Partnership Addressing Wind Energy Forecast Needs by Wilczak, James, Finley, Cathy, Freedman, Jeff, Cline, Joel, Bianco, Laura, Olson, Joseph, Djalalova, Irina, Sheridan, Lindsay, Ahlstrom, Mark, Manobianco, John, Zack, John, Carley, Jacob R., Benjamin, Stan, Coulter, Richard, Berg, Larry K., Mirocha, Jeffrey, Clawson, Kirk, Natenberg, Edward, Marquis, Melinda

“…The Wind Forecast Improvement Project (WFIP) is a public–private research program, the goal of which is to improve the accuracy of short-term (0–6 h) wind…”
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EVALUATING AND IMPROVING NWP FORECAST MODELS FOR THE FUTURE: How the Needs of Offshore Wind Energy Can Point the Way by Banta, Robert M., Pichugina, Yelena L., Brewer, W. Alan, James, Eric P., Olson, Joseph B., Benjamin, Stanley G., Carley, Jacob R., Bianco, Laura, Djalalova, Irina V., Wilczak, James M., Hardesty, R. Michael, Cline, Joel, Marquis, Melinda C.

“…To advance the understanding of meteorological processes in offshore coastal regions, the spatial variability of wind profiles must be characterized and…”
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ON BRIDGING A MODELING SCALE GAP: Mesoscale to Microscale Coupling for Wind Energy: This work has advanced coupled mesoscale to microscale modeling through the terra incognita, generating turbulence at the microscale, testing coupling techniques, and assessing results relevant for wind energy applications by Haupt, Sue Ellen, Kosovic, Branko, Shaw, William, Berg, Larry K, Churchfield, Matthew, Cline, Joel, Draxl, Caroline, Ennis, Brandon, Koo, Eunmo, Kotamarthi, Rao, Mazzaro, Laura, Mirocha, Jeffrey, Moriarty, Patrick, Munoz-Esparza, Domingo, Quon, Eliot, Rai, Raj K, Robinson, Michael, Sever, Gokhan

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