Search Results - "Climer, Sharlee"

Capturing biomarkers associated with Alzheimer disease subtypes using data distribution characteristics by Smith, Kenneth, Climer, Sharlee

“…Late-onset Alzheimer disease (AD) is a highly complex disease with multiple subtypes, as demonstrated by its disparate risk factors, pathological…”
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Linking crop traits to transcriptome differences in a progeny population of tetraploid potato by Alexandersson, Erik, Kushwaha, Sandeep, Subedi, Aastha, Weighill, Deborah, Climer, Sharlee, Jacobson, Daniel, Andreasson, Erik

“…Potato is the third most consumed crop in the world. Breeding for traits such as yield, product quality and pathogen resistance are main priorities…”
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Allele-specific network reveals combinatorial interaction that transcends small effects in psoriasis GWAS by Climer, Sharlee, Templeton, Alan R, Zhang, Weixiong

“…Hundreds of genetic markers have shown associations with various complex diseases, yet the "missing heritability" remains alarmingly elusive. Combinatorial…”
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Structural variants identified using non-Mendelian inheritance patterns advance the mechanistic understanding of autism spectrum disorder by Kainer, David, Templeton, Alan R., Prates, Erica T., Jacboson, Daniel, Allan, Euan R.O., Climer, Sharlee, Garvin, Michael R.

“…The heritability of autism spectrum disorder (ASD), based on 680,000 families and five countries, is estimated to be nearly 80%, yet heritability reported from…”
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Climatic Clustering and Longitudinal Analysis with Impacts on Food, Bioenergy, and Pandemics by Lagergren, John, Cashman, Mikaela, Vergara, Verónica G. Melesse, Eller, Paul R., Gazolla, Joao Gabriel Felipe Machado, Chhetri, Hari B., Streich, Jared, Climer, Sharlee, Thornton, Peter, Joubert, Wayne, Jacobson, Daniel

“…Predicted growth in world population will put unparalleled stress on the need for sustainable energy and global food production, as well as increase the…”
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Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer’s and coronary disease pathways by Wang, Lihua, Western, Daniel, Timsina, Jigyasha, Repaci, Charlie, Song, Won-Min, Norton, Joanne, Kohlfeld, Pat, Budde, John, Climer, Sharlee, Butt, Omar H., Jacobson, Daniel, Garvin, Michael, Templeton, Alan R., Campagna, Shawn, O’Halloran, Jane, Presti, Rachel, Goss, Charles W., Mudd, Philip A., Ances, Beau M., Zhang, Bin, Sung, Yun Ju, Cruchaga, Carlos

“…Identification of proteins dysregulated by COVID-19 infection is critically important for better understanding of its pathophysiology, building prognostic…”
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A machine‐learning approach to biomarker evaluation for AD precision medicine by Climer, Sharlee

“…Background Late‐onset Alzheimer disease (AD) is a heterogeneous disease, as demonstrated by its wide range of genetic and environmental risk factors, as well…”
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Latitudinal Clines of the Human Vitamin D Receptor and Skin Color Genes by Tiosano, Dov, Audi, Laura, Climer, Sharlee, Zhang, Weixiong, Templeton, Alan R, Fernández-Cancio, Monica, Gershoni-Baruch, Ruth, Sánchez-Muro, José Miguel, El Kholy, Mohamed, Hochberg, Zèev

“…The well-documented latitudinal clines of genes affecting human skin color presumably arise from the need for protection from intense ultraviolet radiation…”
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Phytobiome and Transcriptional Adaptation of Populus deltoides to Acute Progressive Drought and Cyclic Drought by Garcia, Benjamin J., Labbé, Jessy L., Jones, Piet, Abraham, Paul E., Hodge, Ian, Climer, Sharlee, Jawdy, Sara, Gunter, Lee, Tuskan, Gerald A., Yang, Xiaohan, Tschaplinski, Timothy J., Jacobson, Daniel A.

“…Plant drought stress causes systematic changes to photosynthesis, metabolism, growth, and potentially the phytobiome. Additionally, drought affects plants in…”
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AUC Undermines AD Biomarker Discovery by Smith, Kenneth, Climer, Sharlee

“…Background Efforts are underway to accelerate precision medicine for late‐onset Alzheimer disease (AD). The realization of this endeavor can only be attained…”
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Connecting the dots: The boons and banes of network modeling by Climer, Sharlee

“…Network modeling transforms data into a structure of nodes and edges such that edges represent relationships between pairs of objects, then extracts clusters…”
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Correlation network analysis of cortical mRNA transcripts in an AD case‐control study by Lea, Jamie, Climer, Sharlee

“…Background The genetic basis for Alzheimer Disease is heterogenous and not fully understood. Correlation pattern analysis in cortical tissue can help identify…”
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COVID-19 and the differential dilemma by Climer, Sharlee

“…The conundrums of choosing candidate genes, via differential expression between treated and mock specimens, are tackled by Ghandikota et al. in this issue of…”
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Parallel accelerated Custom Correlation Coefficient calculations for genomics applications by Joubert, Wayne, Nance, James, Climer, Sharlee, Weighill, Deborah, Jacobson, Daniel

“…•A novel mapping of 2-way and 3-way CCC calculations to GPUs is presented.•A parallel algorithm scaling to thousands of compute nodes is developed.•Near-ideal…”
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Network Modeling of Complex Data Sets by Jones, Piet, Weighill, Deborah, Shah, Manesh, Climer, Sharlee, Schmutz, Jeremy, Sreedasyam, Avinash, Tuskan, Gerald, Jacobson, Daniel

“…We demonstrate a selection of network and machine learning techniques useful in the analysis of complex datasets, including 2-way similarity networks, Markov…”
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Human gephyrin is encompassed within giant functional noncoding yin–yang sequences by Climer, Sharlee, Templeton, Alan R., Zhang, Weixiong

“…Gephyrin is a highly conserved gene that is vital for the organization of proteins at inhibitory receptors, molybdenum cofactor biosynthesis and other diverse…”
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Parallel accelerated Custom Correlation Coefficient calculations for genomics applications by Joubert, Wayne, Nance, James, Climer, Sharlee, Weighill, Deborah, Jacobson, Daniel

“…The massive quantities of genomic data being made available through gene sequencing techniques are enabling breakthroughs in genomic science in many areas such…”
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Allele-Specific Network Reveals Combinatorial Interaction That Transcends Small Effects in Psoriasis GWAS: e1003766 by Climer, Sharlee, Templeton, Alan R, Zhang, Weixiong

“…Hundreds of genetic markers have shown associations with various complex diseases, yet the "missing heritability" remains alarmingly elusive. Combinatorial…”
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Cut-and-solve: An iterative search strategy for combinatorial optimization problems by Climer, Sharlee, Zhang, Weixiong

“…Branch-and-bound and branch-and-cut use search trees to identify optimal solutions to combinatorial optimization problems. In this paper, we introduce an…”
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Moving from capstones toward cornerstones: successes and challenges in applying systems biology to identify mechanisms of autism spectrum disorders by Kopp, Nathan, Climer, Sharlee, Dougherty, Joseph D

“…The substantial progress in the last few years toward uncovering genetic causes and risk factors for autism spectrum disorders (ASDs) has opened new…”
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