Search Results - "Clifton, Andrew D."

P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases by Lopez-Castejon, Gloria, Theaker, Jill, Pelegrin, Pablo, Clifton, Andrew D, Braddock, Martin, Surprenant, Annmarie

“…The ATP-gated P2X(7) receptor (P2X(7)R) is a promising therapeutic target in chronic inflammatory diseases with highly specific antagonists currently under…”
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P2X7 Receptor-Mediated Release of Cathepsins from Macrophages Is a Cytokine-Independent Mechanism Potentially Involved in Joint Diseases by Lopez-Castejon, Gloria, Theaker, Jill, Pelegrin, Pablo, Clifton, Andrew D., Braddock, Martin, Surprenant, Annmarie

“…The ATP-gated P2X7 receptor (P2X7R) is a promising therapeutic target in chronic inflammatory diseases with highly specific antagonists currently under…”
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Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB by Deak, Maria, Clifton, Andrew D., Lucocq, John M., Alessi, Dario R.

“…We have identified a novel mitogen‐ and stress‐activated protein kinase (MSK1) that contains two protein kinase domains in a single polypeptide. MSK1 is…”
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Activation of the Neutrophil NADPH Oxidase Is Inhibited by SB 203580, a Specific Inhibitor of SAPK2/p38 by Lal, Aroon S., Clifton, Andrew D., Rouse, John, Segal, Anthony W., Cohen, Philip

“…Activation of the neutrophil NADPH oxidase by either the bacterial peptide fMLP or phorbol myristate acetate (PMA) is partially suppressed by SB 203580, a…”
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The p38/Reactivating Kinase Mitogen-activated Protein Kinase Cascade Mediates the Activation of the Transcription Factor Insulin Upstream Factor 1 and Insulin Gene Transcription by High Glucose in Pancreatic β-Cells by Macfarlane, Wendy M., Smith, Stuart B., James, Roger F.L., Clifton, Andrew D., Doza, Yair N., Cohen, Philip, Docherty, Kevin

“…Insulin upstream factor 1 (IUF1), a transcription factor present in pancreatic β-cells, binds to the sequence C(C/T)TAATG present at several sites within the…”
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A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress by Clifton, Andrew D., Young, Peter R., Cohen, Philip

“…MAPKAP kinase-2 and MAPKAP kinase-3 were both activated in response to cellular stress, interleukin-1 and tumour necrosis factor in KB and HeLa cells, and with…”
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The p38/Reactivating Kinase Mitogen-activated Protein Kinase Cascade Mediates the Activation of the Transcription Factor Insulin Upstream Factor 1 and Insulin Gene Transcription by High Glucose in Pancreatic β-Cells by Wendy M. Macfarlane, Stuart B. Smith, Roger F. L. James, Andrew D. Clifton, Yair N. Doza, Philip Cohen, Kevin Docherty

“…Insulin upstream factor 1 (IUF1), a transcription factor present in pancreatic β-cells, binds to the sequence C(C/T)TAATG present at several sites within the…”
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