Search Results - "Clift, Michael D."

Oxidative Coupling of Enolates, Enol Silanes, and Enamines: Methods and Natural Product Synthesis by Guo, Fenghai, Clift, Michael D., Thomson, Regan J.

“…Oxidative coupling of enolates, enol silanes, and enamines provides a direct method for the construction of useful 1,4‐dicarbonyl synthons. Despite its first…”
Get full text

Development of a Merged Conjugate Addition/Oxidative Coupling Sequence. Application to the Enantioselective Total Synthesis of Metacycloprodigiosin and Prodigiosin R1 by Clift, Michael D, Thomson, Regan J

“…A merged conjugate addition/oxidative coupling sequence that represents an efficient strategy for preparing structurally diverse pyrroles has been developed…”
Get full text

Exploiting Alkylquinone Tautomerization for the Total Synthesis of Calothrixin A and B by Mori-Quiroz, Luis M, Dekarske, Madeline M, Prinkki, Austin B, Clift, Michael D

“…The pentacyclic alkaloid calothrixin B (1) has been synthesized in 5 steps from murrayaquinone A (9). The key step involved the union of boryl aniline 31 with…”
Get full text

Total Synthesis of the Galbulimima Alkaloid (−)-GB17 by Larson, Reed T., Clift, Michael D., Thomson, Regan J.

“…A tale of two Michaels: The first enantioselective total synthesis of (−)‐GB17 is reported. Construction of this unique naphthoquinolizinone skeleton was…”
Get full text

Quinone-catalyzed oxidative deformylation: synthesis of imines from amino alcohols by Liu, Xinyun, Phan, Johnny H, Haugeberg, Benjamin J, Londhe, Shrikant S, Clift, Michael D

“…A new method for imine synthesis by way of quinone-catalyzed oxidative deformylation of 1,2-amino alcohols is reported. A wide range of readily accessible…”
Get full text

Oxidative Carbon−Carbon Bond Formation via Silyl Bis-enol Ethers:  Controlled Cross-Coupling for the Synthesis of Quaternary Centers by Clift, Michael D, Taylor, Carla N, Thomson, Regan J

“…Unsymmetrical silyl bis-enol ethers have been developed as effective substrates for synthesizing quaternary centers from tetralone derivatives through…”
Get full text

Direct β‑Alkylation of Aldehydes via Photoredox Organocatalysis by Terrett, Jack A, Clift, Michael D, MacMillan, David W. C

“…Direct β-alkylation of saturated aldehydes has been accomplished by synergistically combining photo­redox catalysis and organo­catalysis. Photon-induced…”
Get full text

Formal α‑Allylation of Primary Amines by a Dearomative, Palladium-Catalyzed Umpolung Allylation of N‑(Aryloxy)imines by Mori-Quiroz, Luis M, Londhe, Shrikant S, Clift, Michael D

“…N-(Aryloxy)­imines, readily accessible by condensation/tautomerization of (pseudo)­benzylic primary amines and 2,6-di-tert-butyl-1,4-benzoquinone, undergo…”
Get full text

Exploiting Iminoquinones as Electrophilic at Nitrogen “N+” Synthons for C–N Bond Construction by Mori-Quiroz, Luis M, Comadoll, Chelsea G, Super, Jonathan E, Clift, Michael D

“…New methods for C–N bond construction exploiting the N-centered electrophilic character of iminoquinones are reported. Iminoquinones, generated in situ via the…”
Get full text

A Unified Strategy for the Syntheses of the Isoquinolinium Alkaloids Berberine, Coptisine, and Jatrorrhizine by Mori-Quiroz, Luis M, Hedrick, Sidnee L, De Los Santos, Andrew R, Clift, Michael D

“…Total syntheses of the antibacterial alkaloids berberine, coptisine, and jatrorrhizine have been achieved in four steps through a unified route. The key step…”
Get full text

Exploiting Alkylquinone Tautomerization: Amine Benzylation by Mori-Quiroz, Luis M, Clift, Michael D

“…A general protocol for the synthesis of benzylic amines via side-chain amination of alkylquinones is reported. The reactions are initiated by the…”
Get full text

Amine Functionalization through Sequential Quinone-Catalyzed Oxidation/Nucleophilic Addition by Leon, Martin A., Liu, Xinyun, Phan, Johnny H., Clift, Michael D.

“…A simple and efficient method for the synthesis of α‐branched amines through formal oxidative C–H functionalization is reported. A commercially available…”
Get full text

Enantioselective Total Synthesis and Confirmation of the Absolute and Relative Stereochemistry of Streptorubin B by Hu, Dennis X., Clift, Michael D., Lazarski, Kiel E., Thomson, Regan J.

“…The enantioselective total synthesis of the pyrrolophane natural product streptorubin B is described. Key steps in the concise route include the application of…”
Get full text

Correction to “Exploiting Alkylquinone Tautomerization for the Total Synthesis of Calothrixin A and B” by Mori-Quiroz, Luis M, Dekarske, Madeline M, Prinkki, Austin B, Clift, Michael D

Get full text

Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase by Clift, Michael D., Silverman, Richard B.

“…The design, synthesis, and evaluation of novel γ-aminobutyric acid aminotransferase (GABA-AT) inhibitors and inactivators can lead to the discovery of new…”
Get full text

Enantiomers of 4-Amino-3-fluorobutanoic Acid as Substrates for γ-Aminobutyric Acid Aminotransferase. Conformational Probes for GABA Binding by Clift, Michael D, Ji, Haitao, Deniau, Gildas P, O'Hagan, David, Silverman, Richard B

“…γ-Aminobutyric acid aminotransferase (GABA-AT), a pyridoxal 5‘-phosphate dependent enzyme, catalyzes the degradation of the inhibitory neurotransmitter…”
Get full text

Total Synthesis of the Galbulimima Alkaloid (−)‐GB17 by Larson, Reed T., Clift, Michael D., Thomson, Regan J.

Get full text

Total Synthesis of the Galbulimima Alkaloid (−)-GB17 by Larson, Reed T., Clift, Michael D., Thomson, Regan J.

“…Alles unter Kontrolle! Die erste enantioselektive Totalsynthese von (−)‐GB17 wurde entwickelt. Der Aufbau dieses einzigartigen Naphthochinolizinon‐Gerüstes…”
Get full text