Search Results - "Cleynhens, B."

RP-HPLC separation of the diastereomers of technetium-99m labelled tropanes and identity confirmation using radio-LC-MS by Vanbilloen, H.P., Cleynhens, B.J., de Groot, T.J., Maes, A., Bormans, G.M., Verbruggen, A.M.

“…99mTc-TRODAT-1…”
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Influence of the bifunctional chelate on the biological behavior of (99m)Tc-labeled chemotactic peptide conjugates by Verbeke, K, Snauwaert, K, Cleynhens, B, Scheers, W, Verbruggen, A

“…Conjugates of For-MLFK and For-NleLFNleYK with S-benzyl mercaptoacetyl dipeptides containing, respectively, zero, one, and two carboxyl functions in their…”
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99mTc-M-TRODAT is not superior to 99mTc-TRODAT-1 for the diagnosis of Parkinson's disease by Maes, A., Vanbilloen, H., Cleynhens, B., Mortelmans, L., Bormans, G., Verbruggen, A.

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Synthesis and evaluation of the (99m)tc-complexes of L-cysteine acetyldiglycine (a hybrid of MAG3 and L,L-EC) and of L-beta-homocysteine acetyldiglycine by Mang'era, K, Vanbilloen, H, Cleynhens, B, de Groot T, Bormans, G, Verbruggen, A, Verbeke, K

“…L-Cysteine acetyldiglycine (L-CAG2), a hybrid compound of L,L-EC and MAG3, and its L-beta-homocysteine analogue L-HAG2 were synthesized. After labeling with…”
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Synthesis, radio-LC-MS analysis and biodistribution in mice of 99mTc-NIM-BAT by Bormans, G., Cleynhens, B., de Groot, T.J., Mortelmans, L., Moretti, J.-L., Verbruggen, A.

“…S,S′‐bis‐trityl‐N‐BOC‐1,2‐ethylenedicysteamine (S,S′‐bis‐trityl‐N‐BOC–BAT) was conjugated to 2‐nitroimidazole (NIM) through a propylene spacer in order to…”
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Importance of the two ester functions for the brain retention of 99mTc-labelled ethylene dicysteine diethyl ester ( 99mTc-ECD) by Vanbilloen, Hubert P, Cleynhens, Bernard J, Verbruggen, Alfons M

“…99mTc-ethylene dicysteine diethyl ester ( 99mTc-L,L-ECD) is a neutral lipophilic tracer agent that crosses the blood-brain barrier and is retained in the brain…”
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Investigation of the labelling characteristics of 99mTc-mercaptoacetyltriglycine by Bormans, G., Cleynhens, B., Adriaens, P., Vanbilloen, H., De Roo, M., Verbruggen, A.

“…S-Benzyl-, S-benzamidomethyl- and S-benzoylmercaptoacetyltriglycine were synthesized and compared in exchange labelling experiments for the preparation of…”
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Comparative evaluation of 99mTc-MAG2-oligodeoxynucleotides with phosphodiester or phosphorothioate backbones: preparation, stability and biodistribution by Hjelstuen, O. K., By, B. C., Cleynhens, B., Ormstad, H. M., Roald, T. E., Tønnesen, H. H., Bremer, P. O., Verbruggen, A. M.

“…Antisense oligodeoxynucleotides (ODNs) conjugated to a suitable bifunctional chelating agent and labelled with a suitable radionuclide could become useful in…”
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Synthesis and biological evaluation of super(68)Ga-bis-DOTA-PA as a potential agent for positron emission tomography imaging of necrosis by Prinsen, K, Cona, M M, Cleynhens, B J, Li, J, Vanbilloen, H, Dyubankova, N, Lescrinier, E, Ni, Y, Bormans, G M, Verbruggen, A M

“…Introduction: Necrosis is a form of cell death that occurs in a variety of pathological conditions but can also be the result of therapy in cancer treatment. A…”
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Comparative evaluation of 99Tcm-Hynic-HSA and 99Tcm-MAG3-HSA as possible blood pool agents by Verbeke, K, Hjelstuen, O, Debrock, E, Cleynhens, B, De Roo, M, Verbruggen, A

“…Two strategies have been used to increase the 99Tcm binding strength of human serum albumin (HSA) and thus enhance its blood retention. In a first approach,…”
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Comparison of tridentate ligands in competition experiments for their ability to form a [ 99mTc(CO) 3] complex by Rattat, Dirk, Eraets, Kristof, Cleynhens, Bernard, Knight, Hector, Fonge, Humphrey, Verbruggen, Alfons

“…Graphic In this study we have compared different ligands containing three or more hetero-atoms (N, O and/or S) with respect to their ability to form tridentate…”
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A convenient configuration for safe and efficient radio-HPLC of 99mTc-radiopharmaceuticals by van Nerom, C, Bormans, G, Cleynhens, B, de Roo, M, Verbruggen, A

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Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [18 F]FECT by Chitneni, Satish K, Garreau, Lucette, Cleynhens, Bernard, Evens, Nele, Bex, Marva, Vermaelen, Peter, Chalon, Sylvie, Busson, Roger, Guilloteau, Denis, Van Laere, Koen, Verbruggen, Alfons, Bormans, Guy

“…Abstract Introduction [2′-[18 F]Fluoroethyl (lR-2-exo-3-exe)-8-methyl-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]-octane-2-carboxylate] ([18 F]FECT) is a positron…”
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Characteristics and biological behaviour of 99mTc-labelled hydroxyacetyltriglycine, a potential alternative to 99mTc-MAG3 by Vanbilloen, H P, Dezutter, N A, Cleynhens, B J, Verbruggen, A M

“…Substitution of the oxidation-sensitive thiol function of mercaptoacetyltriglycine (MAG3) by a hydroxyl group yields a tetraligand (hydroxyacetyltriglycine or…”
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99mTc-M-TRODAT is not superior to (99m)Tc-TRODAT-1 for the diagnosis of Parkinson's disease by Maes, A, Vanbilloen, H, Cleynhens, B, Mortelmans, L, Bormans, G, Verbruggen, A

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Evaluation of 99mTc-mercaptoacetyltripeptides in mice and a baboon by Bormans, G, Cleynhens, B, Hoogmartens, M, de Roo, M, VerBruggen, A

“…Different derivatives of MAG, carrying amino acids such as D- or L-alanine, D-serine, D-2-aminobutyric acid, D-valine or D-phenylglycine were synthesized and…”
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Influence of the bifunctional chelate on the biological behavior of 99mtc-labeled chemotactic peptide conjugates by Verbeke, K, Snauwaert, K, Cleynhens, B, Scheers, W, Verbruggen, A

“…Conjugates of For-MLFK and For-NleLFNleYK with S-benzyl mercaptoacetyl dipeptides containing, respectively, zero, one, and two carboxyl functions in their…”
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Synthesis and biological characteristics of the four stereoisomers of 99mTc-N,N'-bis-(mercaptoacetyl)-2,3-diaminopropanoate by Bormans, G, Cleynhens, B, José, D, Hoogmartens, M, De Roo, M, Verbruggen, A

“…To study the differences in biological behaviour between the four stereoisomers of 99mTc-CO2-DADS we synthesized both the L- and D-isomer of…”
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Synthesis and biological evaluation of the four isomers of technetium-99m labeled ethylenecysteamine cysteine ((99m)Tc-ECC), the mono-acid derivative of (99m)tc-L,L-ethylenedicysteine by Vanbilloen, H P, Cleynhens, B J, Verbruggen, A M

“…A few years ago (99m)Tc-ethylenedicysteine ((99m)Tc-L,L-EC) had been proposed as an interesting substitute for technetium-99m labeled mercaptoacetyltriglycine…”
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Synthesis, radio‐LC–MS analysis and biodistribution in mice of 99m Tc–NIM–BAT by Bormans, G., Cleynhens, B., de Groot, T.J., Mortelmans, L., Moretti, J.‐L., Verbruggen, A.

“…Abstract S , S ′‐ bis ‐trityl‐ N ‐BOC‐1,2‐ethylenedicysteamine ( S , S ′‐ bis ‐trityl‐ N ‐BOC–BAT) was conjugated to 2‐nitroimidazole (NIM) through a propylene…”
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