Search Results - "Clewell, Harvey"

Critical considerations in the review of the toxicological evidence regarding the potential carcinogenicity of aspartame by Gentry, Robinan, Greene, Tracy, Clewell, 3rd, Harvey J, Rodricks, Joseph V

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Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK) by Verner, Marc-André, Loccisano, Anne E, Morken, Nils-Halvdan, Yoon, Miyoung, Wu, Huali, McDougall, Robin, Maisonet, Mildred, Marcus, Michele, Kishi, Reiko, Miyashita, Chihiro, Chen, Mei-Huei, Hsieh, Wu-Shiun, Andersen, Melvin E, Clewell, 3rd, Harvey J, Longnecker, Matthew P

“…Prenatal exposure to perfluoroalkyl substances (PFAS) has been associated with lower birth weight in epidemiologic studies. This association could be…”
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Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment – A case study with parabens by Ouedraogo, Gladys, Alexander-White, Camilla, Bury, Dagmar, Clewell, Harvey J., Cronin, Mark, Cull, Tom, Dent, Matthew, Desprez, Bertrand, Detroyer, Ann, Ellison, Corie, Giammanco, Stefania, Hack, Eric, Hewitt, Nicola J., Kenna, Gerry, Klaric, Martina, Kreiling, Reinhard, Lester, Cathy, Mahony, Catherine, Mombelli, Enrico, Naciff, Jorge, O'Brien, John, Schepky, Andreas, Tozer, Sarah, van der Burg, Bart, van Vugt-Lussenburg, Barbara, Stuard, Sharon, Cosmetics Europe

“…Parabens are esters of para-hydroxybenzoic acid that have been used as preservatives in many types of products for decades including agrochemicals,…”
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Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms by Andersen, Melvin E., Hagenbuch, Bruno, Apte, Udayan, Corton, J. Christopher, Fletcher, Tony, Lau, Christopher, Roth, William L., Staels, Bart, Vega, Gloria L., Clewell, Harvey J., Longnecker, Matthew P.

“…Serum concentrations of cholesterol are positively correlated with exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) in…”
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PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals by Bois, Frédéric Y, Jamei, Masoud, Clewell, Harvey J

“…Abstract Generic PBPK models, applicable to a large number of substances, coupled to parameter databases and QSAR modules, are now available for predictive…”
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Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment by Wetmore, Barbara A., Wambaugh, John F., Ferguson, Stephen S., Sochaski, Mark A., Rotroff, Daniel M., Freeman, Kimberly, Clewell, Harvey J., Dix, David J., Andersen, Melvin E., Houck, Keith A., Allen, Brittany, Judson, Richard S., Singh, Reetu, Kavlock, Robert J., Richard, Ann M., Thomas, Russell S.

“…High-throughput in vitro toxicity screening can provide an efficient way to identify potential biological targets for chemicals. However, relying on nominal…”
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Quantitative in vitro to in vivo extrapolation of cell-based toxicity assay results by Yoon, Miyoung, Campbell, Jerry L., Andersen, Melvin E., Clewell, Harvey J.

“…The field of toxicology is currently undergoing a global paradigm shift to use of in vitro approaches for assessing the risks of chemicals and drugs in a more…”
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Temporal concordance between apical and transcriptional points of departure for chemical risk assessment by Thomas, Russell S, Wesselkamper, Scott C, Wang, Nina Ching Y, Zhao, Q Jay, Petersen, Dan D, Lambert, Jason C, Cote, Ila, Yang, Longlong, Healy, Eric, Black, Michael B, Clewell, 3rd, Harvey J, Allen, Bruce C, Andersen, Melvin E

“…The number of legacy chemicals without toxicity reference values combined with the rate of new chemical development is overwhelming the capacity of the…”
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Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment by Clewell, Rebecca A., Thompson, Chad M., Clewell, Harvey J.

“…Current regulatory practices for chemical carcinogens were established when scientific understanding of the molecular mechanisms of chemical carcinogenesis was…”
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Using quantitative modeling tools to assess pharmacokinetic bias in epidemiological studies showing associations between biomarkers and health outcomes at low exposures by Andersen, Melvin E., Mallick, Pankajini, Clewell, Harvey J., Yoon, Miyoung, Olsen, Geary W., Longnecker, Matthew P.

“…Biomarkers of exposure can be measured at lower and lower levels due to advances in analytical chemistry. Using these sensitive methods, some epidemiology…”
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A model of functional thyroid disease status over the lifetime by Dzierlenga, Michael W, Allen, Bruce C, Ward, Peyton L, Clewell, 3rd, Harvey J, Longnecker, Matthew P

“…Mathematical models of the natural history of disease can predict incidence rates based on prevalence data and support simulations of populations where thyroid…”
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Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach by Tsuji, Joyce S., Chang, Ellen T., Gentry, P. Robinan, Clewell, Harvey J., Boffetta, Paolo, Cohen, Samuel M.

“…The biologic effects of inorganic arsenic predominantly involve reaction of the trivalent forms with sulfhydryl groups in critical proteins in target cells,…”
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Pharmacokinetic bias analysis of an association between clinical thyroid disease and two perfluoroalkyl substances by Dzierlenga, Michael W., Allen, Bruce C., Clewell, Harvey J., Longnecker, Matthew P.

“…•Bias was quantified in an association of clinical thyroid disease with PFAS.•A PBPK model was used to link thyroid disease, renal function and PFAS…”
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Interspecies scaling of toxicity reference values in human health versus ecological risk assessments: A critical review by Clewell, Harvey J., Fuchsman, Phyllis C.

“…Risk assessments that focus on anthropogenic chemicals in environmental media—whether considering human health or ecological effects—often rely on toxicity…”
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High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling by Strope, Cory L., Mansouri, Kamel, Clewell, Harvey J., Rabinowitz, James R., Stevens, Caroline, Wambaugh, John F.

“…•We have replaced a proprietary human variability model with an open-source EPA tool for high throughput risk prioritization.•Introduced the ionizable atom…”
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Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics? by Verner, Marc-André, McDougall, Robin, Glynn, Anders, Andersen, Melvin E, Clewell, 3rd, Harvey J, Longnecker, Matthew P

“…A recent meta-analysis based on data from > 7,000 pregnancies reported an association between prenatal polychlorinated biphenyl (PCB)-153 exposure and reduced…”
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Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework by Thomas, Russell S, Philbert, Martin A, Auerbach, Scott S, Wetmore, Barbara A, Devito, Michael J, Cote, Ila, Rowlands, J Craig, Whelan, Maurice P, Hays, Sean M, Andersen, Melvin E, Meek, M E Bette, Reiter, Lawrence W, Lambert, Jason C, Clewell, 3rd, Harvey J, Stephens, Martin L, Zhao, Q Jay, Wesselkamper, Scott C, Flowers, Lynn, Carney, Edward W, Pastoor, Timothy P, Petersen, Dan D, Yauk, Carole L, Nong, Andy

“…Based on existing data and previous work, a series of studies is proposed as a basis toward a pragmatic early step in transforming toxicity testing. These…”
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A Method to Integrate Benchmark Dose Estimates with Genomic Data to Assess the Functional Effects of Chemical Exposure by Thomas, Russell S., Allen, Bruce C., Nong, Andy, Yang, Longlong, Bermudez, Edilberto, Clewell, Harvey J., Andersen, Melvin E.

“…The use of genomic technology for assessing health risks associated with chemical exposure has significant potential, but its direct application has proven to…”
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Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment by Yoon, Miyoung, Blaauboer, Bas J, Clewell, Harvey J

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Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing by Wetmore, Barbara A, Wambaugh, John F, Allen, Brittany, Ferguson, Stephen S, Sochaski, Mark A, Setzer, R Woodrow, Houck, Keith A, Strope, Cory L, Cantwell, Katherine, Judson, Richard S, LeCluyse, Edward, Clewell, Harvey J, Thomas, Russell S, Andersen, Melvin E

“…We previously integrated dosimetry and exposure with high-throughput screening (HTS) to enhance the utility of ToxCast HTS data by translating in vitro…”
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