Search Results - "Cleverly, A. L."

Development and validation of a phosphorylated SMAD ex vivo stimulation assay by Farrington, D. L., Yingling, J. M., Fill, J. A., Yan, L., Qian, Y-W., Shou, J., Wang, X., Ehsani, M. E., Cleverly, A. L., Daly, T. M., Lahn, M., Konrad, R. J., Ray, C. A.

“…Abstract Assessing the pharmacodynamics (PD) of a potential therapeutic through the use of a downstream biomarker is essential. This is traditionally performed…”
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Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway by Herbertz, Stephan, Sawyer, J Scott, Stauber, Anja J, Gueorguieva, Ivelina, Driscoll, Kyla E, Estrem, Shawn T, Cleverly, Ann L, Desaiah, Durisala, Guba, Susan C, Benhadji, Karim A, Slapak, Christopher A, Lahn, Michael M

“…Transforming growth factor-beta (TGF-β) signaling regulates a wide range of biological processes. TGF-β plays an important role in tumorigenesis and…”
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Phase I study of LY573636-sodium, an acylsulfonamide anti-cancer compound with a novel mechanism of action, administered as 2-hour IV infusion in patients with advanced solid tumors by Ilaria, R. L., Simon, G. R., Sovak, M., Burton, M. K., Cleverly, A. L., Sykes, A. K., De Alwis, D. P., Wagner, M. M., Spriggs, D. R.

“…Abstract only 2515 Background: LY573636 -sodium (hereafter referred to as LY573636 ) is a novel anti-cancer compound that induces apoptosis by a…”
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Sub-lethal effects of tefluthrin on Diabrotica undecimpunctata howardi, Barber: plant protection and larval development by Michaelides, Paris K., Cleverly, Ann L., Wright, Denis J.

“…Larval stages of the southern corn rootworm, Diabrotica undecimpunctata howardi (Barber) (Coleoptera: Chrysomelidae), were used to assess the effects of…”
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