Search Results - "Cleven, Arjen"

Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma by Cleven, Arjen H.G, Höcker, Saskia, Briaire-de Bruijn, Inge, Szuhai, Karoly, Cleton-Jansen, Anne-Marie, Bovée, Judith V.M.G

“…Specific H3F3A driver mutations and IDH2 mutations were recently described in giant cell tumor of bone (GCTB) and H3F3B driver mutations in chondroblastoma;…”
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Increased PD-L1 and T-cell infiltration in the presence of HLA class I expression in metastatic high-grade osteosarcoma: a rationale for T-cell-based immunotherapy by Sundara, Yayan T., Kostine, Marie, Cleven, Arjen H. G., Bovée, Judith V. M. G., Schilham, Marco W., Cleton-Jansen, Anne-Marie

“…Introduction Immunotherapy may be an excellent choice for treating osteosarcoma given its exceptionally high genomic instability, potentially generating…”
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A subset of epithelioid and spindle cell rhabdomyosarcomas is associated with TFCP2 fusions and common ALK upregulation by Le Loarer, François, Cleven, Arjen H. G., Bouvier, Corinne, Castex, Marie-Pierre, Romagosa, Cleofe, Moreau, Anne, Salas, Sébastien, Bonhomme, Benjamin, Gomez-Brouchet, Anne, Laurent, Camille, Le Guellec, Sophie, Audard, Virginie, Giraud, Antoine, Ramos-Oliver, Irma, Cleton-Jansen, Anne-Marie, Savci-Heijink, Dilara C., Kroon, Herman M., Baud, Jessica, Pissaloux, Daniel, Pierron, Gaëlle, Sherwood, Anand, Coindre, Jean Michel, Bovée, Judith V. M. G., Larousserie, Frédérique, Tirode, Franck

“…Rhabdomyosarcomas with TFCP2 fusions represent an emerging subtype of tumors, initially discovered by RNA-sequencing. We report herein the clinicopathological,…”
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Molecular Analysis of Gene Fusions in Bone and Soft Tissue Tumors by Anchored Multiplex PCR–Based Targeted Next-Generation Sequencing by Lam, Suk Wai, Cleton-Jansen, Anne-Marie, Cleven, Arjen H.G., Ruano, Dina, van Wezel, Tom, Szuhai, Karoly, Bovée, Judith V.M.G.

“…Molecular assays for translocation detection in bone and soft tissue tumors have gradually been incorporated into routine diagnostics. However, conventional…”
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Utility of FOS as diagnostic marker for osteoid osteoma and osteoblastoma by Lam, Suk Wai, Cleven, Arjen H. G., Kroon, Herman M., Briaire-de Bruijn, Inge H., Szuhai, Karoly, Bovée, Judith V. M. G.

“…Osteoid osteoma and osteoblastoma are bone-forming tumors shown to harbor FOS (87%) and FOSB (3%) rearrangements. The aim was to evaluate the…”
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Molecular findings in maxillofacial bone tumours and its diagnostic value by Cleven, Arjen H.G., Schreuder, Willem H., Groen, Eline, Kroon, Herman M., Baumhoer, Daniel

“…According to the WHO, mesenchymal tumours of the maxillofacial bones are subdivided in benign and malignant maxillofacial bone and cartilage tumours,…”
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Clinical, Histologic, and Molecular Characteristics of Anaplastic Lymphoma Kinase-positive Primary Cutaneous Anaplastic Large Cell Lymphoma by Melchers, Rutger C., Willemze, Rein, van de Loo, Merel, van Doorn, Remco, Jansen, Patty M., Cleven, Arjen H.G., Solleveld, Nienke, Bekkenk, Marcel W., van Kester, Marloes S., Diercks, Gillis F.H., Vermeer, Maarten H., Quint, Koen D.

“…Unlike systemic anaplastic large cell lymphoma, the vast majority of primary cutaneous anaplastic large cell lymphomas (C-ALCL) do not carry translocations…”
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Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival by Cleven, Arjen H G, Sannaa, Ghadah A Al, Briaire-de Bruijn, Inge, Ingram, Davis R, van de Rijn, Matt, Rubin, Brian P, de Vries, Maurits W, Watson, Kelsey L, Torres, Kelia E, Wang, Wei-Lien, van Duinen, Sjoerd G, Hogendoorn, Pancras C W, Lazar, Alexander J, Bovée, Judith V M G

“…Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that can show overlapping features with benign neurofibromas as well as high-grade…”
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Can Navigation Improve the Ability to Achieve Tumor-free Margins in Pelvic and Sacral Primary Bone Sarcoma Resections? A Historically Controlled Study by Bosma, Sarah E, Cleven, Arjen H G, Dijkstra, P D Sander

“…Anatomic and surgical complexity make pelvic and sacral bone sarcoma resections challenging. Positive surgical margins are more likely to occur in patients…”
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Analysis of PD-L1, T-cell infiltrate and HLA expression in chondrosarcoma indicates potential for response to immunotherapy specifically in the dedifferentiated subtype by Kostine, Marie, Cleven, Arjen HG, de Miranda, Noel F C C, Italiano, Antoine, Cleton-Jansen, Anne-Marie, Bovée, Judith V M G

“…Therapies targeting the programmed cell death 1 (PD-1) or its ligand (PD-L1) promote antitumor T-cell activity, leading to unprecedented long-lasting tumor…”
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RANKL inhibition for giant cell lesions of the jaw: A retrospective cohort analysis by Schreuder, Willem H., Lipplaa, Astrid, Cleven, Arjen H.G., van den Berg, Henk, Bisschop, Peter H., de Jongh, Renate T., Witjes, Max J.H., Kessler, Peter A.W.H., Merkx, Matthias A.W., Edelenbos, Esther, Klop, Cornelis, Schreurs, Ruud, Westermann, Anneke M., Tromp, Jacqueline M., Levenga, Henriette, Gelderblom, Hans, de Lange, Jan

“…In all giant-cell-rich lesions (GCRL) occurring in bone, a common underlying excessive RANKL expression is held responsible for the osteolytic activity. Apart…”
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Oestrogen receptor expression distinguishes non-ossifying fibroma from other giant cell containing bone tumours by Cleven, Arjen H. G., Schreuder, Willem H., Groen, Eline, de Lange, Jan, Briaire-de Bruijn, Inge H., Bovée, Judith V. M. G.

“…Non-ossifying fibroma (NOF) and central giant cell granuloma (CGCG) are both benign tumours of bone with overlapping morphology and similar mutations in the…”
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High prevalence of MYD88 and CD79B mutations in intravascular large B-cell lymphoma by Schrader, Anne M.R., Jansen, Patty M., Willemze, Rein, Vermeer, Maarten H., Cleton-Jansen, Anne-Marie, Somers, Sebastiaan F., Veelken, Hendrik, van Eijk, Ronald, Kraan, Willem, Kersten, Marie José, van den Brand, Michiel, Stevens, Wendy B.C., de Jong, Daphne, Abdul Hamid, Myrurgia, Tanis, Bea C., Posthuma, Eduardus F.M., Nijland, Marcel, Diepstra, Arjan, Pals, Steven T., Cleven, Arjen H.G., Vermaat, Joost S.P.

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Real-world routine diagnostic molecular analysis for TP53 mutational status is recommended over p53 immunohistochemistry in B-cell lymphomas by de Haan, Lorraine M., de Groen, Ruben A. L., de Groot, Fleur A., Noordenbos, Troy, van Wezel, Tom, van Eijk, Ronald, Ruano, Dina, Diepstra, Arjan, Koens, Lianne, Nicolae-Cristea, Alina, Hartog, Wietske C. E. den, Terpstra, Valeska, Ahsmann, Els, Dekker, Tim J. A., Sijs-Szabo, Aniko, Veelken, Hendrik, Cleven, Arjen H. G., Jansen, Patty M., Vermaat, Joost S. P.

“…Previous studies in patients with mature B-cell lymphomas (MBCL) have shown that pathogenic TP53 aberrations are associated with inferior chemotherapeutic…”
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Efficacy and Toxicity of Calcitonin Treatment in Children with Cherubism: A Single‐Center Cohort Study by Schreuder, Willem H., Meijer, Ethan B., Cleven, Arjen H.G., Edelenbos, Esther, Klop, Cornelis, Schreurs, Ruud, Jong, Renate T., Maarle, Merel C., Horsthuis, Roy B.G., Lange, Jan, Berg, Henk

“…ABSTRACT Cherubism is a rare autosomal dominant disease characterized by expansile osteolytic jawbone lesions. The effect and safety of off‐label calcitonin…”
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Small cell osteosarcoma versus fusion-driven round cell sarcomas of bone: retrospective clinical, radiological, pathological, and (epi)genetic comparison with clinical implications by Hiemcke-Jiwa, Laura S., Sumathi, Vaiyapuri P., Baumhoer, Daniel, Smetsers, Stephanie E., Haveman, Lianne M., van Noesel, Max M., van Langevelde, Kirsten, Cleven, Arjen H. G., van de Sande, Michiel A. J., ter Horst, Simone A. J., Kester, Lennart A., Flucke, Uta

“…Small cell osteosarcoma (SCOS), a variant of conventional high-grade osteosarcoma (COS), may mimic fusion-driven round cell sarcomas (FDRCS) by overlapping…”
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Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation by Peterse, Elisabeth F. P., Niessen, Bertine, Addie, Ruben D., de Jong, Yvonne, Cleven, Arjen H. G., Kruisselbrink, Alwine B., van den Akker, Brendy E. W. M., Molenaar, Remco J., Cleton-Jansen, Anne-Marie, Bovée, Judith V. M. G.

“…Introduction Chondrosarcoma is a malignant cartilage-forming bone tumour in which mutations in IDH1 and IDH2 frequently occur. Previous studies suggest an…”
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Expanding the Spectrum of EWSR1-NFATC2-rearranged Benign Tumors: A Common Genomic Abnormality in Vascular Malformation/Hemangioma and Simple Bone Cyst by Ong, Sheena L.M., Lam, Suk Wai, van den Akker, Brendy E.W.M., Kroon, Herman M., Briaire-de Bruijn, Inge H., Cleven, Arjen H.G., Savci-Heijink, Dilara C., Cleton-Jansen, Anne-Marie, Baumhoer, Daniel, Szuhai, Karoly, Bovée, Judith V.M.G.

“…A simple bone cyst (SBC) is a cystic bone lesion predominantly affecting young males. The cyst is lined by a fibrous membrane and filled with serosanguinous…”
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Prognostic Metabolite Biomarkers for Soft Tissue Sarcomas Discovered by Mass Spectrometry Imaging by Lou, Sha, Balluff, Benjamin, Cleven, Arjen H. G., Bovée, Judith V. M. G., McDonnell, Liam A.

“…Metabolites can be an important read-out of disease. The identification and validation of biomarkers in the cancer metabolome that can stratify high-risk…”
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Novel EWSR1::GFI1B gene fusion in angiofibroma of soft tissue by Suurmeijer, Albert J H, Cleven, Arjen H G, Antonescu, Cristina R, Duckworth, Lauren A, Fritchie, Karen J, Billings, Steven D, Dermawan, Josephine K

“…Angiofibroma of soft tissue is a benign soft tissue tumour characterised by bland spindle cells and a distinct branching vascular network. The majority of soft…”
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