Search Results - "Cleutjens, Kitty B."

Cathepsin cysteine proteases in cardiovascular disease by Lutgens, Suzanne P.M, Cleutjens, Kitty B.J.M, Daemen, Mat J.A.P, Heeneman, Sylvia

“…Extracellular matrix (ECM) remodeling is one of the underlying mechanisms in cardiovascular diseases. Cathepsin cysteine proteases have a central role in ECM…”
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Selection into medicine: the predictive validity of an outcome-based procedure by Schreurs, Sanne, Cleutjens, Kitty B, Muijtjens, Arno M M, Cleland, Jennifer, Oude Egbrink, Mirjam G A

“…Medical schools must select students from a large pool of well-qualified applicants. A challenging issue set forward in the broader literature is that of which…”
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Osteoclastic Bone Degradation and the Role of Different Cysteine Proteinases and Matrix Metalloproteinases: Differences Between Calvaria and Long Bone by Everts, Vincent, Korper, Wolf, Hoeben, Kees A, Jansen, Ineke DC, Bromme, Dieter, Cleutjens, Kitty BJM, Heeneman, Sylvia, Peters, Christoph, Reinheckel, Thomas, Saftig, Paul, Beertsen, Wouter

“…Osteoclastic bone degradation involves the activity of cathepsin K. We found that in addition to this enzyme other, yet unknown, cysteine proteinases…”
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Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice by Donners, Marjo M P C, Bai, Lili, Lutgens, Suzanne P M, Wijnands, Erwin, Johnson, Jason, Schurgers, Leon J, Liu, Cong-Lin, Daemen, Mat J A P, Cleutjens, Kitty B J M, Shi, Guo-Ping, Biessen, Erik A L, Heeneman, Sylvia

“…Cathepsin K (catK) is a potent lysosomal cysteine protease involved in extracellular matrix (ECM) degradation and inflammatory remodeling responses. Here we…”
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Assessment of human atherosclerotic carotid plaque components with multisequence MR imaging: initial experience by Cappendijk, Vincent C, Cleutjens, Kitty B J M, Kessels, Alfons G H, Heeneman, Sylvia, Schurink, Geert Willem H, Welten, Rob J T J, Mess, Werner H, Daemen, Mat J A P, van Engelshoven, Jos M A, Kooi, M Eline

“…To prospectively determine, by using a stepwise logistic regression model, the optimal magnetic resonance (MR) weighting (ie, pulse sequence) combinations for…”
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Chemokines CCL3/MIP1α, CCL5/RANTES and CCL18/PARC are independent risk predictors of short-term mortality in patients with acute coronary syndromes by de Jager, Saskia C A, Bongaerts, Brenda W C, Weber, Michael, Kraaijeveld, Adriaan O, Rousch, Mat, Dimmeler, Stefanie, van Dieijen-Visser, Marja P, Cleutjens, Kitty B J M, Nelemans, Patty J, van Berkel, Theo J C, Biessen, Erik A L

“…Cytokines play an important role in ischemic injury and repair. However, little is known about their prognostic value in cardiovascular disease. The aim of…”
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The dynamic extracellular matrix: intervention strategies during heart failure and atherosclerosis by Heeneman, Sylvia, Cleutjens, Jack P, Faber, Birgit C, Creemers, Esther E, van Suylen, Robert-Jan, Lutgens, Esther, Cleutjens, Kitty B, Daemen, Mat J

“…The extracellular matrix is no longer seen as the static embedding in which cells reside; it has been shown to be involved in cell proliferation, migration and…”
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Dead or alive: gene expression profiles of advanced atherosclerotic plaques from autopsy and surgery by Sluimer, Judith C, Kisters, Natasja, Cleutjens, Kitty B, Volger, Oscar L, Horrevoets, Anton J, van den Akker, Luc H, Bijnens, Ann-Pascale J, Daemen, Mat J

“…1 University of Maastricht, Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht 2 Academic Medical Center, Department of Medical…”
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Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis by Segers, Filip M E, Ruder, Adele V, Westra, Marijke M, Lammers, Twan, Dadfar, Seyed Mohammadali, Roemhild, Karolin, Lam, Tin Sing, Kooi, Marianne Eline, Cleutjens, Kitty B J M, Verheyen, Fons K, Schurink, Geert W H, Haenen, Guido R, van Berkel, Theo J C, Bot, Ilze, Halvorsen, Bente, Sluimer, Judith C, Biessen, Erik A L

“…(Ultra) Small superparamagnetic iron oxide nanoparticles, (U)SPIO, are widely used as magnetic resonance imaging contrast media and assumed to be safe for…”
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Outcomes-Based Selection Into Medical School: Predicting Excellence in Multiple Competencies During the Clinical Years by Schreurs, Sanne, Cleutjens, Kitty B.J.M., Cleland, Jennifer, oude Egbrink, Mirjam G.A.

“…PURPOSEMedical school selection committees aim to identify the best possible students and, ultimately, the best future doctors from a large, well-qualified,…”
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Both Early and Delayed Anti-CD40L Antibody Treatment Induces a Stable Plaque Phenotype by Lutgens, Esther, Kitty B. J. M. Cleutjens, Heeneman, Sylvia, Koteliansky, Victor E., Burkly, Linda C., Mat J. A. P. Daemen

“…In the present study, we investigated the role of the CD40L-CD40 pathway in a model of progressive atherosclerosis. ApoE-/- mice were treated with an…”
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Targeted biallelic inactivation of pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis by XIAOQIAN MA, ZIEL-VAN DER MADE, Angelique C, VAN DER KWAST, Theo H, TRAPMAN, Jan, AUTAR, Binha, VAN DER KORPUT, Hetty A, VERMEIJ, Marcel, VAN DUIJN, Petra, CLEUTJENS, Kitty B, DE KRIJGER, Ronald, KRIMPENFORT, Paul, BERNS, Anton

“…The PTEN tumor suppressor gene is frequently inactivated in human tumors, including prostate cancer. Based on the Cre/loxP system, we generated a novel mouse…”
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Vasculin, a novel vascular protein differentially expressed in human atherogenesis by Bijnens, Ann P.J.J., Gils, Ann, Jutten, Barry, Faber, Birgit C.G., Heeneman, Sylvia, Kitslaar, Peter J.E.H.M., Tordoir, Jan H.M., de Vries, Carlie J.M., Kroon, Abraham A., Daemen, Mat J.A.P., Cleutjens, Kitty B.J.M.

“…Recent suppressive subtractive hybridization analysis on human atherosclerotic plaque-derived RNA revealed genes upregulated in plaques with a thrombus versus…”
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A 6-kb Promoter Fragment Mimics in Transgenic Mice the Prostate-Specific and Androgen-Regulated Expression of the Endogenous Prostate-Specific Antigen Gene in Humans by Cleutjens, Kitty B. J .M, van der Korput, Hetty A. G. M, Ehren-van Eekelen, Conny C, Sikes, Robert A, Fasciana, Claudia, Chung, Leland W, Trapman, Jan

“…Prostate-specific antigen (PSA) is a kallikrein-like serine protease, which is almost exclusively synthesized in the luminal epithelial cells of the human…”
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Atherosclerotic Plaque Rupture: Local or Systemic Process? by Lutgens, Esther, van Suylen, Robert-Jan, Faber, Birgit C, Gijbels, Marion J, Eurlings, Petra M, Bijnens, Ann-Pascale, Cleutjens, Kitty B, Heeneman, Sylvia, Daemen, Mat J.A.P

“…ABSTRACT—It is generally established that the unstable plaque is the major cause of acute clinical sequelae of atherosclerosis. Unfortunately, terms indicating…”
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High-sensitive troponin T assay for the diagnosis of acute myocardial infarction: an economic evaluation by Vaidya, Anil, Severens, Johan L, Bongaerts, Brenda W C, Cleutjens, Kitty B J M, Nelemans, Patty J, Hofstra, Leonard, van Dieijen-Visser, Marja, Biessen, Erik A L

“…Delayed diagnosis and treatment of Acute Myocardial Infarction (AMI) has a major adverse impact on prognosis in terms of both morbidity and mortality. Since…”
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Gene profiling in atherosclerosis reveals a key role for small inducible cytokines : Validation using a novel monocyte chemoattractant protein monoclonal antibody by LUTGENS, Esther, FABER, Birgit, MACKAY, Charles R, RENNERT, Paul, BAILLY, Veronique, JARPE, Matthew, DOLINSKI, Brian, KOTELIANSKY, Victor, DE FOUGEROLLES, Tony, DAEMEN, Mat J. A. P, SCHAPIRA, Kitty, EVELO, Chris T. A, VAN HAAFTEN, Rachel, HEENEMAN, Sylvia, CLEUTJENS, Kitty B. J. M, BIJNENS, Ann Pascale, BECKERS, Linda, PORTER, J. Gordon

“…Pathological aspects of atherosclerosis are well described, but gene profiles during atherosclerotic plaque progression are largely unidentified. Microarray…”
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An Androgen Response Element in a Far Upstream Enhancer Region Is Essential for High, Androgen-Regulated Activity of the Prostate-Specific Antigen Promoter by Cleutjens, Kitty B. J. M, van der Korput, Hetty A. G. M, van Eekelen, Conny C. E. M, van Rooij, Henri C. J, Faber, Peter W, Trapman, Jan

“…Prostate-specific antigen (PSA) is expressed at a high level in the luminal epithelial cells of the prostate and is absent or expressed at very low levels in…”
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Comparison of lipid-rich necrotic core size in symptomatic and asymptomatic carotid atherosclerotic plaque: Initial results by Cappendijk, Vincent C., Kessels, Alfons G.H., Heeneman, Sylvia, Cleutjens, Kitty B.J.M., Schurink, Geert Willem H., Welten, Rob J.Th.J., Mess, Werner H., van Suylen, Robert-Jan, Leiner, Tim, Daemen, Mat J.A.P., van Engelshoven, Jos M.A., Kooi, M. Eline

“…Purpose To investigate the potential difference in the size of the lipid‐rich necrotic core (LRNC) in carotid plaques of symptomatic patients versus…”
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Comparison of single-sequence T1w TFE MRI with multisequence MRI for the quantification of lipid-rich necrotic core in atherosclerotic plaque by Cappendijk, Vincent C., Heeneman, Sylvia, Kessels, Alfons G.H., Cleutjens, Kitty B.J.M., Schurink, Geert Willem H., Welten, Rob J.Th.J., Mess, Werner H., van Suylen, Robert-Jan, Leiner, Tim, Daemen, Mat J.A.P., van Engelshoven, Jos M.A., Kooi, M. Eline

“…Purpose To prospectively determine the accuracy of semiquantitative analysis of the amount of lipid‐rich necrotic core (LRNC) in atherosclerotic plaque using…”
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