Search Results - "Clemson, Christine"

A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains by Hutchinson, John N, Ensminger, Alexander W, Clemson, Christine M, Lynch, Christopher R, Lawrence, Jeanne B, Chess, Andrew

“…Noncoding RNA species play a diverse set of roles in the eukaryotic cell. While much recent attention has focused on smaller RNA species, larger noncoding…”
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An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles by Clemson, Christine M., Hutchinson, John N., Sara, Sergio A., Ensminger, Alexander W., Fox, Archa H., Chess, Andrew, Lawrence, Jeanne B.

“…NEAT1 RNA, a highly abundant 4 kb ncRNA, is retained in nuclei in approximately 10 to 20 large foci that we show are completely coincident with paraspeckles,…”
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The Role of Alpha-MSH as a Modulator of Ocular Immunobiology Exemplifies Mechanistic Differences between Melanocortins and Steroids by Clemson, Christine M., Yost, John, Taylor, Andrew W.

“…Melanocortins are a highly conserved family of peptides and receptors that includes multiple proopiomelanocortin-derived peptides and five defined melanocortin…”
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Gene associations: true romance or chance meeting in a nuclear neighborhood? by Lawrence, Jeanne B, Clemson, Christine M

“…Many recent studies have raised interest in the nuclear associations of coregulated genes from different chromosomes, often evoking interpretations of…”
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The X Chromosome Is Organized into a Gene-Rich Outer Rim and an Internal Core Containing Silenced Nongenic Sequences by Clemson, Christine Moulton, Hall, Lisa L., Byron, Meg, McNeil, John, Lawrence, Jeanne Bentley

“…We investigated whether genes escape X chromosome inactivation by positioning outside of the territory defined by XIST RNA. Results reveal an unanticipated…”
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Ubiquitinated proteins including uH2A on the human and mouse inactive X chromosome: enrichment in gene rich bands by Smith, Kelly P, Byron, Meg, Clemson, Christine M, Lawrence, Jeanne B

“…The inactive X chromosome (Xi) forms a heterochromatic structure in the nucleus that is known to have several modifications to specific histones involving…”
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Unbalanced X;autosome translocations provide evidence for sequence specificity in the association of XIST RNA with chromatin by Hall, Lisa L., Clemson, Christine M., Byron, Meg, Wydner, Karen, Lawrence, Jeanne B.

“…Whether XIST RNA is indifferent to the sequence content of the chromosome is fundamental to understanding its mechanism of chromosomal inactivation. Transgenic…”
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Characterization of expression at the human XIST locus in somatic, embryonal carcinoma, and transgenic cell lines by Chow, Jennifer C., Hall, Lisa L., Clemson, Christine M., Lawrence, Jeanne B., Brown, Carolyn J.

“…X inactivation requires XIST, a functional RNA that is expressed exclusively from, and localizes to, the inactive X in female somatic cells. In mouse,…”
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Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials by Meltzer-Brody, Samantha, Colquhoun, Helen, Riesenberg, Robert, Epperson, C Neill, Deligiannidis, Kristina M, Rubinow, David R, Li, Haihong, Sankoh, Abdul J, Clemson, Christine, Schacterle, Amy, Jonas, Jeffrey, Kanes, Stephen

“…Post-partum depression is associated with substantial morbidity, and improved pharmacological treatment options are urgently needed. We assessed brexanolone…”
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Long-term efficacy and safety of odevixibat in patients with progressive familial intrahepatic cholestasis: results with 96 weeks or more of treatment by Thompson, Richard, Durmaz, Ozlem, Grammatikopoulos, Tassos, Di Giorgio, Angelo, Ni, Quanhong, Stein, Philip, Clemson, Christine, Sturm, Ekkehard

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THU-378 - Outcomes in adult patients with progressive familial intrahepatic cholestasis treated with odevixibat: subgroup analysis from the PEDFIC 2 study by Roquelaure, Bertrand, Verkade, Henkjan J., Loomes, Kathleen M., Stoll, Janis M., Clemson, Christine, Gu, Tao, Mattsson, Jan, Stein, Philip

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TOP-057 - Long-term efficacy and safety of odevixibat in patients with progressive familial intrahepatic cholestasis: results with 96 weeks or more of treatment by Thompson, Richard, Durmaz, Ozlem, Grammatikopoulos, Tassos, Di Giorgio, Angelo, Ni, Quanhong, Stein, Philip, Clemson, Christine, Sturm, Ekkehard

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Outcomes in adult patients with progressive familial intrahepatic cholestasis treated with odevixibat: subgroup analysis from the PEDFIC 2 study by Roquelaure, Bertrand, Verkade, Henkjan J., Loomes, Kathleen M., Stoll, Janis M., Clemson, Christine, Gu, Tao, Mattsson, Jan, Stein, Philip

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THU-313 - Odevixibat therapy following liver transplantation in patients with FIC1-deficient progressive familial intrahepatic cholestasis: a retrospective case series by Vogel, Georg-Friedrich, Kathemann, Simone, Pietrobattista, Andrea, Maggiore, Giuseppe, Aldrian, Denise, Sciveres, Marco, Verkade, Henkjan J., Rauschkolb, Peter, Maucksch, Christof, Valcheva, Velichka, Clemson, Christine, Lainka, Elke

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Odevixibat therapy following liver transplantation in patients with FIC1-deficient progressive familial intrahepatic cholestasis: a retrospective case series by Vogel, Georg-Friedrich, Kathemann, Simone, Pietrobattista, Andrea, Maggiore, Giuseppe, Aldrian, Denise, Sciveres, Marco, Verkade, Henkjan J., Rauschkolb, Peter, Maucksch, Christof, Valcheva, Velichka, Clemson, Christine, Lainka, Elke

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F73. Efficacy of Brexanolone Injection in Subjects With Postpartum Depression With and Without Baseline Antidepressant Therapy: Insights From an Integrated Analysis of Three Pivotal Trials by Meltzer-Brody, Samantha, Colquhoun, Helen, Riesenberg, Robert, Epperson, Nell, Deligiannidis, Kristina, Rubinow, David, Li, Haihong, Clemson, Christine, Kanes, Stephen

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Efficacy and safety outcomes with odevixibat treatment: Pooled data from the phase 3 ASSERT and ASSERT-EXT studies in patients with Alagille syndrome by Ovchinsky, Nadia, Aumar, Madeleine, Baker, Alastair, Baumann, Ulrich, Bufler, Philip, Cananzi, Mara, Durmaz, Ozlem, Fischer, Ryan, Indolfi, Giuseppe, Karnsakul, Wikrom, Lacaille, Florence, Lee, Way Seah, Maggiore, Giuseppe, Rosenthal, Philip, Ruiz, Mathias, Sokal, Etienne, Sturm, Ekkehard, van der Woerd, Wendy L., Verkade, Henkjan J., Wehrman, Andrew, Clemson, Christine, Yu, Qifeng, Ni, Quanhong, Ruvido, Jessica, Manganaro, Susan, Mattsson, Jan, Czubkowski, Piotr

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THU-284 - Efficacy and safety outcomes with odevixibat treatment: Pooled data from the phase 3 ASSERT and ASSERT-EXT studies in patients with Alagille syndrome by Ovchinsky, Nadia, Aumar, Madeleine, Baker, Alastair, Baumann, Ulrich, Bufler, Philip, Cananzi, Mara, Durmaz, Ozlem, Fischer, Ryan, Indolfi, Giuseppe, Karnsakul, Wikrom, Lacaille, Florence, Lee, Way Seah, Maggiore, Giuseppe, Rosenthal, Philip, Ruiz, Mathias, Sokal, Etienne, Sturm, Ekkehard, van der Woerd, Wendy L., Verkade, Henkjan J., Wehrman, Andrew, Clemson, Christine, Yu, Qifeng, Ni, Quanhong, Ruvido, Jessica, Manganaro, Susan, Mattsson, Jan, Czubkowski, Piotr

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86: Brexanolone iv efficacy in postpartum depression in three pivotal trials: montgomery-åsberg depression rating scale assessment by Clemson, Christine, Meltzer-Brody, Samantha, Colquhoun, Helen, Riesenberg, Robert, Epperson, C.Neil, Deligiannidis, Kristina, Rubinow, David, Li, Haihong, Kanes, Stephen

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The humanistic burden of postpartum depression: a systematic literature review by Moore Simas, Tiffany A., Huang, Ming-Yi, Patton, Cody, Reinhart, Marcia, Chawla, Anita J., Clemson, Christine, Eldar-Lissai, Adi

“…Objective: Postpartum depression (PPD) is the most common medical complication of childbirth. PPD can be disabling, with potential negative effects on maternal…”
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