Search Results - "Clemmons, D.R"

An anti-αVβ3 antibody inhibits coronary artery atherosclerosis in diabetic pigs by Maile, L.A, Busby, W.H, Xi, G, Gollahan, K.P, Flowers, W, Gafbacik, N, Gafbacik, S, Stewart, K, Merricks, E.P, Nichols, T.C, Bellinger, D.A, Clemmons, D.R

“…Abstract Background and aims Diabetes is a major risk factor for the development of atherosclerosis. Hyperglycemia stimulates vascular smooth muscle cells (…”
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Complement 1s is the serine protease that cleaves IGFBP-5 in human osteoarthritic joint fluid by Busby, W.H., Ph.D, Yocum, S.A., Ph.D, Rowland, M, Kellner, D, Lazerwith, S., Ph.D, Sverdrup, F., Ph.D, Yates, M, Radabaugh, M., Ph.D, Clemmons, D.R., M.D

“…Summary Insulin-like growth factor-I (IGF-I) and IGF binding proteins (IGFBPs) are trophic factors for cartilage and have been shown to be chondroprotective in…”
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OR13,5 IGFBP-2 null mice develop obesity and insulin resistance with aging by DeMambro, V.E, Rosen, C.J, Clemmons, D.R

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OR11,4 A monoclonal antibody that targets a novel site on the beta3 subunit of the alphaVbeta3 integrin blocks lesion development in a porcine model of diabetes accelerated atherosclerosis by Maile, L.A, Busby, W.H, Nichols, T.C, Bellinger, D.A, Merricks, E.P, Rowlands, M, Veluvolu, U, Clemmons, D.R

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A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation by James, P.L., Jones, S.B., Busby, W H, Clemmons, D.R., Rotwein, P

“…Insulin-like growth factor-binding proteins (IGFBPs) are a family of secreted proteins that bind insulin-like growth factors I and II (IGFs I and II) and are…”
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PDB82 Development of a Novel Algorithm to Identify Individuals with Possible Adult Growth Hormone Deficiency from a US Administrative Claims Database by Birkegård, C., Blevins, L.S., Clemmons, D.R., Fleseriu, M., Hoffman, A.R., Kerr, J.M., Sun, T., Tarp, J., Tritos, N.A., Yuen, K.

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PDB83 Application of a Novel Algorithm to Identify Individuals with Possible Adult Growth Hormone Deficiency in the US: A Retrospective, Administrative Claims Database Study by Yuen, K., Birkegård, A.C., Blevins, L.S., Clemmons, D.R., Fleseriu, M., Hoffman, A.R., Kelepouris, N., Kerr, J.M., Tarp, J., Tritos, N.A.

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Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101 by J I Jones, W H Busby, Jr, G Wright, C E Smith, N M Kimack, D R Clemmons

“…Serine phosphorylation of insulin-like growth factor binding protein-1 (IGFBP-1) has been shown to alter its affinity for the insulin-like growth factors…”
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Expression and characterization of a serine protease that preferentially cleaves insulin-like growth factor binding protein-5 by Hou, J., Clemmons, D.R., Smeekens, S.

“…Insulin‐like growth factor binding proteins (IGFBPs) play important roles in regulating the functions of insulin‐like growth factors (IGFs). Because IGFBPs…”
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Rh/IGF-I/rhIGFBP-3 administration to patients with type 2 diabetes mellitus reduces insulin requirements while also lowering fasting glucose by Clemmons, D.R., Moses, A.C., Sommer, A., Jacobson, W., Rogol, A.D., Sleevi, M.R., Allan, G.

“…Administration of insulin-like growth factor-I to patients with diabetes enhances insulin action and reduces the degree of hyperglycemia but it is associated…”
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Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion by C Camacho-Hubner, W H Busby, Jr, R H McCusker, G Wright, D R Clemmons

“…Human fibroblasts secrete insulin-like growth factor-binding proteins (IGFBPs) that can modify insulin-like growth factor (IGF) I action. We have determined…”
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Phosphorylation of Insulin-Like Growth Factor (IGF)-Binding Protein 1 in Cell Culture and in vivo: Effects on Affinity for IGF-I by Jones, J I, D'Ercole, A J, Camacho-Hubner, C, Clemmons, D R

“…The insulin-like growth factors (IGF-I and IGF-II) are present in extracellular fluids bound to specific IGF-binding proteins (IGFBPs). We and others have…”
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Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes by T Arai, A Parker, W Busby, Jr, D R Clemmons

“…The mechanisms by which insulin-like growth factor-I (IGF-I) is released from insulin-like growth factor binding proteins (IGFBPs) and then binds to its…”
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A non-IGF binding mutant of IGFBP-3 modulates cell function in breast epithelial cells by Perks, C.M, McCaig, C, Clarke, J.B, Clemmons, D.R, Holly, J.M.P

“…We demonstrated previously that IGFBP-3 alone had no effect on cell death, but dramatically modulated apoptosis in Hs578T IGF non-responsive cells. We…”
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Effects of a non-IGF binding mutant of IGFBP-5 on cell death in human breast cancer cells by Perks, C.M., McCaig, C., Clarke, J.B., Clemmons, D.R., Holly, J.M.P.

“…We have demonstrated previously that IGFBP-5 alone had no effect on cell death but modulated ceramide-induced apoptosis in Hs578T IGF non-responsive cells. To…”
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An Insulin-Like Growth Factor (IGF) Binding Protein Enhances the Biologic Response to IGF-I by Elgin, R. G., Busby, W. H., Clemmons, D. R.

“…The insulin-like growth factors IGF-I and IGF-II circulate in blood bound to carrier proteins. The higher molecular mass IGF-binding protein complex (150 kDa)…”
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The Effect of Extracellular Matrix Proteins on Porcine Smooth Muscle Cell Insulin-like Growth Factor (IGF) Binding Protein-5 Synthesis and Responsiveness to IGF-I by Zheng, Bo, Duan, Cumming, Clemmons, David R.

“…The aim of this study was to determine if cultured porcine vascular smooth muscle cells (pSMCs) that had been maintained on different extracellular matrix…”
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Inhibition of IGFBP-5 binding to extracellular matrix and IGF-I-stimulated DNA synthesis by a peptide fragment of IGFBP-5 by Rees, C., Clemmons, D.R.

“…Insulin‐like growth factor binding protein‐5 (IGFBP‐5) is synthesized and secreted by smooth muscle cells (SMC). IGFBP‐5 synthesis is stimulated five‐ to…”
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Nutrient balance and stage of lactation affect responses of insulin, insulin-like growth factors I and II, and insulin-like growth factor-binding protein 2 to somatotropin administration in dairy cows by Vicini, J L, Buonomo, F C, Veenhuizen, J J, Miller, M A, Clemmons, D R, Collier, R J

“…Six Holstein cows were used in a complete block design to examine effects of period of lactation and somatotropin (bST) administration on concentrations of…”
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Transcapillary permeability and subendothelial distribution of endothelial and amniotic fluid insulin-like growth factor binding proteins in the rat heart by Bar, R S, Clemmons, D R, Boes, M, Busby, W H, Booth, B A, Dake, B L, Sandra, A

“…Insulin-like growth factor (IGF) binding proteins (IGFBP) were purified from conditioned media of cultured bovine endothelial cells (ECBP) and from human…”
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