Search Results - "Clements, Carol"

Metabolomics-Guided Isolation of Anti-trypanosomal Metabolites from the Endophytic Fungus Lasiodiplodia theobromae by Kamal, Nurkhalida, Viegelmann, Christina V, Clements, Carol J, Edrada-Ebel, RuAngelie

“…Fungal endophytes offer diverse and unique secondary metabolites, making these organisms potential sources of promising drug leads. The application of…”
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Chemical and Antimicrobial Profiling of Propolis from Different Regions within Libya by Siheri, Weam, Zhang, Tong, Ebiloma, Godwin Unekwuojo, Biddau, Marco, Woods, Nicola, Hussain, Muattaz Yassein, Clements, Carol J, Fearnley, James, Ebel, RuAngelie Edrada, Paget, Timothy, Muller, Sylke, Carter, Katharine C, Ferro, Valerie A, De Koning, Harry P, Watson, David G

“…Extracts from twelve samples of propolis collected from different regions of Libya were tested for their activity against Trypanosoma brucei, Leishmania…”
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Targeted Isolation of Anti-Trypanosomal Naphthofuran-Quinone Compounds from the Mangrove Plant Avicennia lanata by Mazlan, Noor Wini, Clements, Carol, Edrada-Ebel, RuAngelie

“…The discovery of new secondary metabolites from natural origins has become more challenging in natural products research. Different approaches have been…”
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The Chemical Characterization of Nigerian Propolis samples and Their Activity Against Trypanosoma brucei by Omar, Ruwida, Igoli, John O., Zhang, Tong, Gray, Alexander I., Ebiloma, Godwin U., Clements, Carol J., Fearnley, James, Edrada Ebel, RuAngeli, Paget, Tim, de Koning, Harry P., Watson, David G.

“…Profiling of extracts from twelve propolis samples collected from eight regions in Nigeria was carried out using high performance liquid chromatography (LC)…”
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Communication Between Traditional Medical Practitioners and Western Medical Professionals by Lampiao, Fanuel, Chisaka, Joseph, Clements, Carol

“…The high burden of disease in Malawi is exacerbated by a lack of healthcare professionals, and the inaccessibility of healthcare services to many Malawians,…”
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Antitrypanosomal activity & docking studies of isolated constituents from the lichen Cetraria islandica: possibly multifunctional scaffolds by Igoli, John Ogbaji, Gray, Alexander Irvine, Clements, Carol Jean, Kantheti, Poorna, Singla, Rajeev Kumar

“…Chemical investigation of the lichen Cetraria islandica has led to the isolation of four compounds identified as protolichesterinic acid, lichesterinic acid,…”
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Antitrypanosomal activity & docking studies of components of Crateva adansonii DC leaves: novel multifunctional scaffolds by Igoli, Ngozichukwuka Peace, Clements, Carol Jean, Singla, Rajeev Kumar, Igoli, John Ogbaji, Uche, Nzekwe, Gray, Alexander Irvine

“…Chemical investigation of Crateva adansonii DC has led to the isolation of aurantiamide acetate, a novel ethyl pyropheophorbide A, purpurin-18 ethyl ester and…”
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Metabolomic Profiling of the Synergistic Effects of Melittin in Combination with Cisplatin on Ovarian Cancer Cells by Alonezi, Sanad, Tusiimire, Jonans, Wallace, Jennifer, Dufton, Mark J, Parkinson, John A, Young, Louise C, Clements, Carol J, Park, Jin-Kyu, Jeon, Jong-Woon, Ferro, Valerie A, Watson, David G

“…Melittin, the main peptide present in bee venom, has been proposed as having potential for anticancer therapy; the addition of melittin to cisplatin, a first…”
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Antimicrobial Properties and Cytotoxicity of Sulfated (1,3)-β-D-Glucan from the Mycelium of the Mushroom Ganoderma lucidum by Wan-Mohtar, Wan Abd Al Qadr Imad, Young, Louise, Abbott, Gráinne M, Clements, Carol, Harvey, Linda M, McNeil, Brian

“…Ganoderma lucidum BCCM 31549 has a long established role for its therapeutic activities. In this context, much interest has focused on the possible functions…”
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Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology by Alonezi, Sanad, Tusiimire, Jonans, Wallace, Jennifer, Dufton, Mark J, Parkinson, John A, Young, Louise C, Clements, Carol J, Park, Jin Kyu, Jeon, Jong Woon, Ferro, Valerie A, Watson, David G

“…In the present study, liquid chromatography-mass spectrometry (LC-MS) was employed to characterise the metabolic profiles of two human ovarian cancer cell…”
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Isolation of Antiprotozoal Compounds from Libyan Propolis by Siheri, Weam, Igoli, John O, Gray, Alexander I, Nasciemento, Ticiano G, Zhang, Tong, Fearnley, James, Clements, Carol J, Carter, Katharine C, Carruthers, John, Edrada‐Ebel, RuAngelie, Watson, David G

“…Propolis is increasingly being explored as a source of biologically active compounds. Until now, there has been no study of Libyan propolis. Two samples were…”
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Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT by Clark, Rachel L., Clements, Carol J., Barrett, Michael P., Mackay, Simon P., Rathnam, Rajendra P., Owusu-Dapaah, George, Spencer, John, Huggan, Judith K.

“…A library of 1,4-benzodiazepines and quinazoline-2,4-diones has been synthesised that display MIC values as low as 0.97μM against Trypanosoma brucei. A library…”
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An LCMS method for the assay of melittin in cosmetic formulations containing bee venom by Tusiimire, Jonans, Wallace, Jennifer, Dufton, Mark, Parkinson, John, Clements, Carol J., Young, Louise, Park, Jin Kyu, Jeon, Jong Woon, Watson, David G.

“…There is a growing interest in the potential of bee venom in cosmetics as a rejuvenating agent. Products currently on the market do not specify exactly their…”
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Isolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge Haliclona simulans by Viegelmann, Christina, Parker, Jennifer, Ooi, Thengtheng, Clements, Carol, Abbott, Gráinne, Young, Louise, Kennedy, Jonathan, Dobson, Alan D W, Edrada-Ebel, RuAngelie

“…The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3β,24-diol and…”
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Effect of Bee Venom and Its Fractions on the Release of Pro-Inflammatory Cytokines in PMA-Differentiated U937 Cells Co-Stimulated with LPS by Tusiimire, Jonans, Wallace, Jennifer, Woods, Nicola, Dufton, Mark J, Parkinson, John A, Abbott, Grainne, Clements, Carol J, Young, Louise, Park, Jin Kyu, Jeon, Jong Woon, Ferro, Valerie A, Watson, David G

“…The venom of Apis mellifera (honey bee) has been reported to play a role in immunotherapy, but existing evidence to support its immuno-modulatory claims is…”
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A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling by Gebruers, Evelien, Cordero-Maldonado, María Lorena, Gray, Alexander I, Clements, Carol, Harvey, Alan L, Edrada-Ebel, Ruangelie, de Witte, Peter A M, Crawford, Alexander D, Esguerra, Camila V

“…Zebrafish have recently emerged as an attractive model for the in vivo bioassay-guided isolation and characterization of pharmacologically active small…”
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Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity by Spencer, John, Rathnam, Rajendra P., Harvey, Alan L., Clements, Carol J., Clark, Rachel L., Barrett, Michael P., Wong, Pui Ee, Male, Louise, Coles, Simon J., Mackay, Simon P.

“…A library of 1,4-benzodiazepines has been synthesized and displays MIC values as low as 0.78μM against Trypanosoma brucei. A library of 1,4-benzodiazepines has…”
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Antimicrobial Properties and Cytotoxicity of Sulfated (1,3)-β-D-Glucan from the Mycelium of the Mushroom Ganoderma lucidum by Wan-Mohtar, Wan Abd Al Qadr Imad, Young, Louise, Abbott, Grainne M, Clements, Carol, Harvey, Linda M, McNeil, Brian

“…Ganoderma lucidum BCCM 31549 has a long established role for its therapeutic activities. In this context, much interest has focused on the possible functions…”
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Side-on binding of p-sulphonatocalix[4]arene to the dinuclear platinum complex trans-[{PtCl(NH 3) 2} 2μ-dpzm] 2+ and its implications for anticancer drug delivery by Wheate, Nial J., Abbott, Grainne M., Tate, Rothwelle J., Clements, Carol J., Edrada-Ebel, RuAngelie, Johnston, Blair F.

“…The utility of p-sulphonatocalix[4]arene (s-CX[4]) as a drug delivery vehicle for multinuclear platinum anticancer agents, using trans-[{PtCl(NH 3) 2} 2μ-dpzm]…”
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Infectivity of macrophages and the histopathology of cutaneous lesions, liver and spleen is attenuated by leaf extract of Vernonia amygdalina in Leishmania major infected BALB/c mice by Alawa, Judith N, Carter, Katharine C, Nok, Andrew J, Kwanashie, Helen O, Adebisi, Sunday S, Alawa, Clement B I, Clements, Carol J

“…Preliminary investigation of the in vitro and in vivo efficacies of different extracts from the leaves of Vernonia amygdalina (VA), a plant widely used in…”
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