Search Results - "Clemens, Laura E."

Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro by Walter, Carolin, Clemens, Laura E., Müller, Amelie J., Fallier-Becker, Petra, Proikas-Cezanne, Tassula, Riess, Olaf, Metzger, Silke, Nguyen, Huu Phuc

“…The expansion of a polyglutamine repeat in huntingtin (HTT) causes Huntington disease (HD). Although the exact pathogenesis is not entirely understood, mutant…”
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The calpain-suppressing effects of olesoxime in Huntington's disease by Weber, Jonasz J., Ortiz Rios, Midea M., Riess, Olaf, Clemens, Laura E., Nguyen, Huu P.

“…Olesoxime, a small molecule drug candidate, has recently attracted attention due to its significant beneficial effects in models of several neurodegenerative…”
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A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease by Yu-Taeger, Libo, Petrasch-Parwez, Elisabeth, Osmand, Alexander P, Redensek, Adriana, Metzger, Silke, Clemens, Laura E, Park, Larry, Howland, David, Calaminus, Carsten, Gu, Xiaofeng, Pichler, Bernd, Yang, X William, Riess, Olaf, Nguyen, Huu Phuc

“…Huntington disease (HD) is an inherited progressive neurodegenerative disorder, characterized by motor, cognitive, and psychiatric deficits as well as…”
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CB1 Signaling in Forebrain and Sympathetic Neurons Is a Key Determinant of Endocannabinoid Actions on Energy Balance by Quarta, Carmelo, Bellocchio, Luigi, Mancini, Giacomo, Mazza, Roberta, Cervino, Cristina, Braulke, Luzie J., Fekete, Csaba, Latorre, Rocco, Nanni, Cristina, Bucci, Marco, Clemens, Laura E., Heldmaier, Gerhard, Watanabe, Masahiko, Leste-Lassere, Thierry, Maitre, Marlène, Tedesco, Laura, Fanelli, Flaminia, Reuss, Stefan, Klaus, Susanne, Srivastava, Raj Kamal, Monory, Krisztina, Valerio, Alessandra, Grandis, Annamaria, De Giorgio, Roberto, Pasquali, Renato, Nisoli, Enzo, Cota, Daniela, Lutz, Beat, Marsicano, Giovanni, Pagotto, Uberto

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Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat by Clemens, Laura E, Weber, Jonasz J, Wlodkowski, Tanja T, Yu-Taeger, Libo, Michaud, Magali, Calaminus, Carsten, Eckert, Schamim H, Gaca, Janett, Weiss, Andreas, Magg, Janine C D, Jansson, Erik K H, Eckert, Gunter P, Pichler, Bernd J, Bordet, Thierry, Pruss, Rebecca M, Riess, Olaf, Nguyen, Huu P

“…Huntington's disease is a fatal human neurodegenerative disorder caused by a CAG repeat expansion in the HTT gene, which translates into a mutant huntingtin…”
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(1)H NMR based metabolomics of CSF and blood serum: a metabolic profile for a transgenic rat model of Huntington disease by Verwaest, Kim A, Vu, Trung N, Laukens, Kris, Clemens, Laura E, Nguyen, Huu P, Van Gasse, Bjorn, Martins, José C, Van Der Linden, Annemie, Dommisse, Roger

“…Huntington disease (HD) is a hereditary brain disease. Although the causative gene has been found, the exact mechanisms of the pathogenesis are still unknown…”
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Mitochondrial Membrane Fluidity is Consistently Increased in Different Models of Huntington Disease: Restorative Effects of Olesoxime by Eckmann, Janett, Clemens, Laura E., Eckert, Schamim H., Hagl, Stephanie, Yu-Taeger, Libo, Bordet, Thierry, Pruss, Rebecca M., Muller, Walter E., Leuner, Kristina, Nguyen, Huu P., Eckert, Gunter P.

“…Huntington disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of the huntingtin gene ( HTT ). One prominent target…”
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Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat by Clemens, Laura E., Weber, Jonasz J., Wlodkowski, Tanja T., Yu-Taeger, Libo, Michaud, Magali, Calaminus, Carsten, Eckert, Schamim H., Gaca, Janett, Weiss, Andreas, Magg, Janine C. D., Jansson, Erik K. H., Eckert, Gunter P., Pichler, Bernd J., Bordet, Thierry, Pruss, Rebecca M., Riess, Olaf, Nguyen, Huu P.

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1H NMR based metabolomics of CSF and blood serum: A metabolic profile for a transgenic rat model of Huntington disease by Verwaest, Kim A., Vu, Trung N., Laukens, Kris, Clemens, Laura E., Nguyen, Huu P., Van Gasse, Bjorn, Martins, José C., Van Der Linden, Annemie, Dommisse, Roger

“…Huntington disease (HD) is a hereditary brain disease. Although the causative gene has been found, the exact mechanisms of the pathogenesis are still unknown…”
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Performance evaluation of texture measures for ground cover identification in satellite images by means of a neural network classifier by Augusteijn, M.F., Clemens, L.E., Shaw, K.A.

“…The performance of several feature extraction methods for classifying ground covers in satellite images is compared. Ground covers are viewed as texture of the…”
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L20 Olesoxime targets calpain overactivation in models of huntington’s disease by Weber, Jonasz J, Ortiz-Rios, Midea M, Klumpp, Lukas, Kaltenbach, Linda S, Lo, Don C, Huber, Stephan M, Riess, Olaf, Clemens, Laura E, Nguyen, Huu P

“…BackgroundA long-term treatment study of BACHD rats with olesoxime, a mitochondria-targeting drug, revealed beneficial effects on specific behavioural and…”
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C3 Reduced cell size and enhanced cell proliferation are characteristics of sthdhq111/111 cells and should be considered as possible confounding factors by Clemens, Laura E, Walter, Carolin, Singer, Elisabeth, Weber, Jonasz J, Krahl, Ann-Christin, Mau-Holzmann, Ulrike A, Rischert, Nadine, Nguyen, Huu P

“…BackgroundThe STHdh cell lines are immortalised striatal precursor cells from wild type and Hdh Q111 knock-in mice and are commonly used to study the molecular…”
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CB sub(1) Signaling in Forebrain and Sympathetic Neurons Is a Key Determinant of Endocannabinoid Actions on Energy Balance by Quarta, Carmelo, Bellocchio, Luigi, Mancini, Giacomo, Mazza, Roberta, Cervino, Cristina, Braulke, Luzie J, Fekete, Csaba, Latorre, Rocco, Nanni, Cristina, Bucci, Marco, Clemens, Laura E, Heldmaier, Gerhard, Watanabe, Masahiko, Leste-Lassere, Thierry, Maitre, Marlene, Tedesco, Laura, Fanelli, Flaminia, Reuss, Stefan, Klaus, Susanne, Srivastava, Raj Kamal, Monory, Krisztina, Valerio, Alessandra, Grandis, Annamaria, Giorgio, Roberto De, Pasquali, Renato, Nisoli, Enzo, Cota, Daniela, Lutz, Beat, Marsicano, Giovanni, Pagotto, Uberto

“…The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB sub(1)) has been…”
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CB 1 Signaling in Forebrain and Sympathetic Neurons Is a Key Determinant of Endocannabinoid Actions on Energy Balance by Quarta, Carmelo, Bellocchio, Luigi, Mancini, Giacomo, Mazza, Roberta, Cervino, Cristina, Braulke, Luzie J., Fekete, Csaba, Latorre, Rocco, Nanni, Cristina, Bucci, Marco, Clemens, Laura E., Heldmaier, Gerhard, Watanabe, Masahiko, Leste-Lassere, Thierry, Maitre, Marlène, Tedesco, Laura, Fanelli, Flaminia, Reuss, Stefan, Klaus, Susanne, Srivastava, Raj Kamal, Monory, Krisztina, Valerio, Alessandra, Grandis, Annamaria, De Giorgio, Roberto, Pasquali, Renato, Nisoli, Enzo, Cota, Daniela, Lutz, Beat, Marsicano, Giovanni, Pagotto, Uberto

“…The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB 1) has been…”
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CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance by Quarta, Carmelo, Bellocchio, Luigi, Mancini, Giacomo, Mazza, Roberta, Cervino, Cristina, Braulke, Luzie J, Fekete, Csaba, Latorre, Rocco, Nanni, Cristina, Bucci, Marco, Clemens, Laura E, Heldmaier, Gerhard, Watanabe, Masahiko, Leste-Lassere, Thierry, Maitre, Marlène, Tedesco, Laura, Fanelli, Flaminia, Reuss, Stefan, Klaus, Susanne, Srivastava, Raj Kamal, Monory, Krisztina, Valerio, Alessandra, Grandis, Annamaria, De Giorgio, Roberto, Pasquali, Renato, Nisoli, Enzo, Cota, Daniela, Lutz, Beat, Marsicano, Giovanni, Pagotto, Uberto

“…The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB(1)) has been…”
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A neural-network approach to the detection of texture boundaries by Augusteijn, Marijke F., Clemens, Laura E.

“…A neural-network architecture is used here to find boundaries between differently textured surfaces in an image. The architecture is trained on boundaries…”
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Continued Fractions and Series by Clemens, L.E., Merrill, K.D., Roeder, D.W.

“…Explicit formulae are given relating continued fractions with almost periodic or almost symmetric patterns in their partial quotients, and infinite series…”
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